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Molecular Considerations in Cell Transplant Imaging

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Book cover Cell Therapy

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

Cell transplantation, similar to organ transplantation, has the ability to provide dynamic treatments to patients that can keep pace with the demands of their lives, yet most cell transplantation therapies do not succeed in treating the patient. Transplant imaging has been developed to explore why cell transplantation can fail as a therapy. However, to date, transplant imaging has primarily focused on potential issues at the cellular level, assessing the number and/or location of transplanted cells present after administration. Lack of survival and migration data are only two of the reasons why cell transplantation can fail as a therapy. Imaging the molecular environment can interrogate the other limitations of candidate therapies: misdirected differentiation, unstable phenotype, reduced functionality, and non-ideal cellular interactions. Detecting these unintended outcomes faster using molecular imaging strategies will allow clinicians to make therapeutic adjustments before failure occurs. More informative imaging strategies will also permit tailoring cell transplants into more robust, patient-specific therapies for personalized medicine.

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Authors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, MRB 651, 733 N. Broadway, Baltimore, MD, 21205, USA

    Aline M. Thomas Ph.D. & Jeff W. M. Bulte Ph.D.

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    Dwaine F. Emerich

  2. Paseo de la Universidad 7, Vitoria-Gasteiz, Spain

    Gorka Orive

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Thomas, A.M., Bulte, J.W.M. (2017). Molecular Considerations in Cell Transplant Imaging. In: Emerich, D., Orive, G. (eds) Cell Therapy. Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-57153-9_1

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