Abstract
Mitosis is a process requiring strict spatial organization of cellular components. In particular, the orientation of the mitotic spindle with respect to the tissue defines the division plane. In turn, the orientation of cell division can regulate tissue morphology or the fate of daughter cells. While we have learned much about the mechanisms of mitotic spindle orientation, recent studies suggest that the proteins implicated can also play important roles in post-mitotic cells. Interestingly, post-mitotic protein function often involves polarizing the cell cytoskeleton during differentiation, mirroring its ability to orient the mitotic spindle during division. This review focuses on alternative functions of the spindle orientation machinery after division, when the cell undergoes a specialization process associated with differentiation or mature function, and discusses diseases associated to those alternative functions.
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Noatynska A, Gotta M, Meraldi P (2012) Mitotic spindle (DIS)orientation and DISease: cause or consequence? J Cell Biol 199(7):1025–1035
Bergstralh DT, St Johnston D (2014) Spindle orientation: what if it goes wrong? Semin Cell Dev Biol 34:140–145
Fischer E, Legue E, Doyen A, Nato F, Nicolas JF, Torres V, Yaniv M, Pontoglio M (2006) Defective planar cell polarity in polycystic kidney disease. Nat Genet 38(1):21–23
Nakajima Y, Meyer EJ, Kroesen A, McKinney SA, Gibson MC (2013) Epithelial junctions maintain tissue architecture by directing planar spindle orientation. Nature 500(7462):359–362
Pease JC, Tirnauer JS (2011) Mitotic spindle misorientation in cancer—out of alignment and into the fire. J Cell Sci 124(Pt 7):1007–1016
Gillies TE, Cabernard C (2011) Cell division orientation in animals. Curr Biol 21(15):R599–R609
Kulukian A, Fuchs E (2013) Spindle orientation and epidermal morphogenesis. Philos Trans R Soc Lond Ser B Biol Sci 368(1629):20130016
Lancaster MA, Knoblich JA (2012) Spindle orientation in mammalian cerebral cortical development. Curr Opin Neurobiol 22(5):737–746
Lu MS, Johnston CA (2013) Molecular pathways regulating mitotic spindle orientation in animal cells. Development 140(9):1843–1856
Morin X, Bellaiche Y (2011) Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Dev Cell 21(1):102–119
Poulson ND, Lechler T (2012) Asymmetric cell divisions in the epidermis. Int Rev Cell Mol Biol 295:199–232
Nguyen-Ngoc T, Afshar K, Gonczy P (2007) Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans. Nat Cell Biol 9(11):1294–1302
Couwenbergs C, Labbe JC, Goulding M, Marty T, Bowerman B, Gotta M (2007) Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol 179(1):15–22
Park DH, Rose LS (2008) Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. Dev Biol 315(1):42–54
Lechler T, Fuchs E (2005) Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437(7056):275–280
Poulson ND, Lechler T (2010) Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol 191(5):915–922
Williams SE, Beronja S, Pasolli HA, Fuchs E (2011) Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature 470(7334):353–358
Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E (2014) Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol 16(8):758–769
Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F (2008) Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol 10(1):93–101
Morin X, Jaouen F, Durbec P (2007) Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium. Nat Neurosci 10(11):1440–1448
Postiglione MP, Juschke C, Xie Y, Haas GA, Charalambous C, Knoblich JA (2011) Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron 72(2):269–284
Zigman M, Cayouette M, Charalambous C, Schleiffer A, Hoeller O, Dunican D, McCudden CR, Firnberg N, Barres BA, Siderovski DP et al (2005) Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron 48(4):539–545
Gonczy P (2008) Mechanisms of asymmetric cell division: flies and worms pave the way. Nat Rev Mol Cell Biol 9(5):355–366
Wodarz A, Ramrath A, Grimm A, Knust E (2000) Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol 150(6):1361–1374
Kuchinke U, Grawe F, Knust E (1998) Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka. Curr Biol 8(25):1357–1365
Goldstein B, Macara IG (2007) The PAR proteins: fundamental players in animal cell polarization. Dev Cell 13(5):609–622
Schober M, Schaefer M, Knoblich JA (1999) Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402(6761):548–551
Wodarz A, Ramrath A, Kuchinke U, Knust E (1999) Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402(6761):544–547
Kraut R, Chia W, Jan LY, Jan YN, Knoblich JA (1996) Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383(6595):50–55
Parmentier ML, Woods D, Greig S, Phan PG, Radovic A, Bryant P, O’Kane CJ (2000) Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J Neurosci 20(14):RC84
Yu F, Morin X, Cai Y, Yang X, Chia W (2000) Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100(4):399–409
Schaefer M, Shevchenko A, Shevchenko A, Knoblich JA (2000) A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Curr Biol 10(7):353–362
Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich JA (2001) Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 107(2):183–194
Du Q, Macara IG (2004) Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119(4):503–516
Du Q, Stukenberg PT, Macara IG (2001) A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol 3(12):1069–1075
Siller KH, Cabernard C, Doe CQ (2006) The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat Cell Biol 8(6):594–600
Bowman SK, Neumuller RA, Novatchkova M, Du Q, Knoblich JA (2006) The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell 10(6):731–742
Izumi Y, Ohta N, Hisata K, Raabe T, Matsuzaki F (2006) Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat Cell Biol 8(6):586–593
Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Galphai/LGN/NuMA pathways. Mol Cell 43(3):418–431
Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M (2011) Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions. PNAS 108(52):20998–21003
Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, Sumimoto H (2011) Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). PNAS 108(48):19210–19215
Kotak S, Busso C, Gonczy P (2012) Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol 199(1):97–110
Kaushik R, Yu F, Chia W, Yang X, Bahri S (2003) Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression. Mol Biol Cell 14(8):3144–3155
Natochin M, Gasimov KG, Artemyev NO (2001) Inhibition of GDP/GTP exchange on G alpha subunits by proteins containing G-protein regulatory motifs. Biochemistry 40(17):5322–5328
Blumer JB, Cismowski MJ, Sato M, Lanier SM (2005) AGS proteins: receptor-independent activators of G-protein signaling. Trends Pharmacol Sci 26(9):470–476
Yoshiura S, Ohta N, Matsuzaki F (2012) Tre1 GPCR signaling orients stem cell divisions in the Drosophila central nervous system. Dev Cell 22(1):79–91
Afshar K, Willard FS, Colombo K, Johnston CA, McCudden CR, Siderovski DP, Gonczy P (2004) RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell 119(2):219–230
Couwenbergs C, Spilker AC, Gotta M (2004) Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. Curr Biol 14(20):1871–1876
David NB, Martin CA, Segalen M, Rosenfeld F, Schweisguth F, Bellaiche Y (2005) Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nat Cell Biol 7(11):1083–1090
Hampoelz B, Hoeller O, Bowman SK, Dunican D, Knoblich JA (2005) Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. Nat Cell Biol 7(11):1099–1105
Wang H, Ng KH, Qian H, Siderovski DP, Chia W, Yu F (2005) Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol 7(11):1091–1098
VanDongen AM (2009) Biology of the NMDA receptor. CRC Press, Boca Raton
Sans N, Wang PY, Du Q, Petralia RS, Wang YX, Nakka S, Blumer JB, Macara IG, Wenthold RJ (2005) mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol 7(12):1179–1190
Oliva C, Escobedo P, Astorga C, Molina C, Sierralta J (2012) Role of the MAGUK protein family in synapse formation and function. Dev Neurobiol 72(1):57–72
Knoblich JA (2005) Pins for spines. Nat Cell Biol 7(12):1157–1158
Bourne JN, Harris KM (2008) Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci 31:47–67
Hunt DL, Castillo PE (2012) Synaptic plasticity of NMDA receptors: mechanisms and functional implications. Curr Opin Neurobiol 22(3):496–508
Wiser O, Qian X, Ehlers M, Ja WW, Roberts RW, Reuveny E, Jan YN, Jan LY (2006) Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron 50(4):561–573
Sanada K, Tsai LH (2005) G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell 122(1):119–131
Bowers MS, McFarland K, Lake RW, Peterson YK, Lapish CC, Gregory ML, Lanier SM, Kalivas PW (2004) Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. Neuron 42(2):269–281
Yao L, McFarland K, Fan P, Jiang Z, Inoue Y, Diamond I (2005) Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior. Proc Natl Acad Sci USA 102(24):8746–8751
Groves B, Gong Q, Xu Z, Huntsman C, Nguyen C, Li D, Ma D (2007) A specific role of AGS3 in the surface expression of plasma membrane proteins. Proc Natl Acad Sci USA 104(46):18103–18108
Johns DC, Marx R, Mains RE, O’Rourke B, Marban E (1999) Inducible genetic suppression of neuronal excitability. J Neurosci Off J Soc Neurosci 19(5):1691–1697
Wang F (2009) The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol 1(4):a002980
Neptune ER, Bourne HR (1997) Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci USA 94(26):14489–14494
Stephens L, Milne L, Hawkins P (2008) Moving towards a better understanding of chemotaxis. Curr Biol 18(11):R485–R494
Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H (2013) The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway. Dev Cell 26(3):292–302
Wright CE, Kushner EJ, Du Q, Bautch VL (2015) LGN directs interphase endothelial cell behavior via the microtubule network. PLoS One 10(9):e0138763
Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP et al (2013) Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol 15(9):1107–1115
Tarchini B, Jolicoeur C, Cayouette M (2013) A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell 27(1):88–102
Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M et al (2016) The GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome 27(1–2):29–46
Goodrich LV, Strutt D (2011) Principles of planar polarity in animal development. Development 138(10):1877–1892
Shotwell SL, Jacobs R, Hudspeth AJ (1981) Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles. Ann N Y Acad Sci 374:1–10
Jones C, Roper VC, Foucher I, Qian D, Banizs B, Petit C, Yoder BK, Chen P (2008) Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69–77
Montcouquiol M, Rachel RA, Lanford PJ, Copeland NG, Jenkins NA, Kelley MW (2003) Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423(6936):173–177
Almomani R, Sun Y, Aten E, Hilhorst-Hofstee Y, Peeters-Scholte CM, van Haeringen A, Hendriks YM, den Dunnen JT, Breuning MH, Kriek M et al (2013) GPSM2 and Chudley-McCullough syndrome: a Dutch founder variant brought to North America. Am J Med Genet A 161A(5):973–976
Diaz-Horta O, Sirmaci A, Doherty D, Nance W, Arnos K, Pandya A, Tekin M (2012) GPSM2 mutations in Chudley-McCullough syndrome. Am J Med Genet A 158A(11):2972–2973
Doherty D, Chudley AE, Coghlan G, Ishak GE, Innes AM, Lemire EG, Rogers RC, Mhanni AA, Phelps IG, Jones SJ et al (2012) GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Am J Hum Genet 90(6):1088–1093
Walsh T, Shahin H, Elkan-Miller T, Lee MK, Thornton AM, Roeb W, Abu Rayyan A, Loulus S, Avraham KB, King MC et al (2010) Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet 87(1):90–94
Yariz KO, Walsh T, Akay H, Duman D, Akkaynak AC, King MC, Tekin M (2012) A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Clin Genet 81(3):289–293
Chudley AE, McCullough C, McCullough DW (1997) Bilateral sensorineural deafness and hydrocephalus due to foramen of Monro obstruction in sibs: a newly described autosomal recessive disorder. Am J Med Genet 68(3):350–356
Alrashdi I, Barker R, Patton MA (2011) Chudley-McCullough syndrome: another report and a brief review of the literature. Clin Dysmorphol 20(2):107–110
Hilgert N, Smith RJ, Van Camp G (2009) Function and expression pattern of nonsyndromic deafness genes. Curr Mol Med 9(5):546–564
Speicher S, Fischer A, Knoblich J, Carmena A (2008) The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors. Curr Biol 18(11):831–837
Wee B, Johnston CA, Prehoda KE, Doe CQ (2011) Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation. J Cell Biol 195(3):369–376
Carminati M, Cecatiello V, Mapelli M (2016) Crystallization and X-ray diffraction of LGN in complex with the actin-binding protein afadin. Acta Crystallogr Sect F Struct Biol Commun 72(Pt 2):145–151
Carminati M, Gallini S, Pirovano L, Alfieri A, Bisi S, Mapelli M (2016) Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation. Nat Struct Mol Biol 23(2):155–163
Mandai K, Rikitake Y, Shimono Y, Takai Y (2013) Afadin/AF-6 and canoe: roles in cell adhesion and beyond. Prog Mol Biol Transl Sci 116:433–454
Beaudoin GM 3rd, Schofield CM, Nuwal T, Zang K, Ullian EM, Huang B, Reichardt LF (2012) Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci Off J Soc Neurosci 32(1):99–110
Xie Z, Huganir RL, Penzes P (2005) Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron 48(4):605–618
Miyata M, Ogita H, Komura H, Nakata S, Okamoto R, Ozaki M, Majima T, Matsuzawa N, Kawano S, Minami A et al (2009) Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor. J Cell Sci 122(Pt 23):4319–4329
Slovakova J, Speicher S, Sanchez-Soriano N, Prokop A, Carmena A (2012) The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline. J Neurosci Off J Soc Neurosci 32(29):10035–10044
Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN (2003) The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell 4(2):273–281
Hasson T, Mooseker MS (1994) Porcine myosin-VI: characterization of a new mammalian unconventional myosin. J Cell Biol 127(2):425–440
Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL (1999) Myosin VI is an actin-based motor that moves backwards. Nature 401(6752):505–508
Avraham KB, Hasson T, Steel KP, Kingsley DM, Russell LB, Mooseker MS, Copeland NG, Jenkins NA (1995) The mouse Snell’s waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet 11(4):369–375
Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T et al (2003) Mutations of MYO6 are associated with recessive deafness, DFNB37. Am J Hum Genet 72(5):1315–1322
Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M et al (2001) MYO6, the human homologue of the gene responsible for deafness in Snell’s waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Am J Hum Genet 69(3):635–640
Self T, Sobe T, Copeland NG, Jenkins NA, Avraham KB, Steel KP (1999) Role of myosin VI in the differentiation of cochlear hair cells. Dev Biol 214(2):331–341
Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S (2009) Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses. Hum Mol Genet 18(23):4615–4628
Osterweil E, Wells DG, Mooseker MS (2005) A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168(2):329–338
Chibalina MV, Poliakov A, Kendrick-Jones J, Buss F (2010) Myosin VI and optineurin are required for polarized EGFR delivery and directed migration. Traffic 11(10):1290–1303
Buss F, Kendrick-Jones J, Lionne C, Knight AE, Cote GP, Paul Luzio J (1998) The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J Cell Biol 143(6):1535–1545
Geisbrecht ER, Montell DJ (2002) Myosin VI is required for E-cadherin-mediated border cell migration. Nat Cell Biol 4(8):616–620
Woodard GE, Huang NN, Cho H, Miki T, Tall GG, Kehrl JH (2010) Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol 30(14):3519–3530
Kataria R, Xu X, Fusetti F, Keizer-Gunnink I, Jin T, van Haastert PJ, Kortholt A (2013) Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci USA 110(16):6424–6429
Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I et al (2010) Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 67(3):392–406
Elias S, Thion MS, Yu H, Sousa CM, Lasgi C, Morin X, Humbert S (2014) Huntingtin regulates mammary stem cell division and differentiation. Stem Cell Rep 2(4):491–506
Elias S, McGuire JR, Yu H, Humbert S (2015) Huntingtin is required for epithelial polarity through RAB11A-mediated apical trafficking of PAR3-aPKC. PLoS Biol 13(5):e1002142
Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS (2003) Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40(1):25–40
Gauthier LR, Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H, Cordelieres FP, De Mey J, MacDonald ME, Lessmann V, Humbert S et al (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118(1):127–138
Colin E, Zala D, Liot G, Rangone H, Borrell-Pages M, Li XJ, Saudou F, Humbert S (2008) Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J 27(15):2124–2134
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Tadenev, A.L.D., Tarchini, B. (2017). The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization. In: Gotta, M., Meraldi, P. (eds) Cell Division Machinery and Disease. Advances in Experimental Medicine and Biology, vol 1002. Springer, Cham. https://doi.org/10.1007/978-3-319-57127-0_9
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