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Cell Division Machinery and Disease pp 209–225Cite as

The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1002))

Abstract

Mitosis is a process requiring strict spatial organization of cellular components. In particular, the orientation of the mitotic spindle with respect to the tissue defines the division plane. In turn, the orientation of cell division can regulate tissue morphology or the fate of daughter cells. While we have learned much about the mechanisms of mitotic spindle orientation, recent studies suggest that the proteins implicated can also play important roles in post-mitotic cells. Interestingly, post-mitotic protein function often involves polarizing the cell cytoskeleton during differentiation, mirroring its ability to orient the mitotic spindle during division. This review focuses on alternative functions of the spindle orientation machinery after division, when the cell undergoes a specialization process associated with differentiation or mature function, and discusses diseases associated to those alternative functions.

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Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, ME, 04609, USA

    Abigail L. D. Tadenev & Basile Tarchini

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  1. Abigail L. D. Tadenev
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  2. Basile Tarchini
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Correspondence to Basile Tarchini .

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  1. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Monica Gotta

  2. Department of Cell Physiology and Metabolism, Faculty of Medicine, Geneva University, Geneva, Switzerland

    Patrick Meraldi

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Tadenev, A.L.D., Tarchini, B. (2017). The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization. In: Gotta, M., Meraldi, P. (eds) Cell Division Machinery and Disease. Advances in Experimental Medicine and Biology, vol 1002. Springer, Cham. https://doi.org/10.1007/978-3-319-57127-0_9

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