Abstract
The presence of supernumerary centrosomes is a hallmark of human tumours. Recent work in animal models suggests that extra centrosomes are not just bystanders in cancer but can accelerate tumourigenesis in the absence of the tumour suppressor p53. Centrosome amplification could indeed actively participate in tumour progression through the induction of chromosome instability, disruption of tissue architecture and promoting cell invasion. Paradoxically, however, centrosome amplification is rather poorly tolerated in normal cells and there are several hurdles cells need to overcome in order to efficiently proliferate in the presence of extra centrosomes. Here, we review the adaptation mechanisms that allow cells to efficiently divide in the presence of extra centrosomes and how these could be exploited to develop selective cancer therapies.
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Acknowledgments
We thank Hefin Rhys and members of the Godinho laboratory, Teresa Arnandis, Pedro Monteiro and Sophie Adams, for critically reading this manuscript. We apologise for the many authors whose work we were unable to cite due to space limitations. A.D.R. is supported by a CRUK PhD fellowship. S.A.G. is supported by the Higher Education Funding Council for England and a Medical Research Council Grant. S.A.G. is a Lister Institute Prize Fellow.
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Rhys, A.D., Godinho, S.A. (2017). Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells. In: Gotta, M., Meraldi, P. (eds) Cell Division Machinery and Disease. Advances in Experimental Medicine and Biology, vol 1002. Springer, Cham. https://doi.org/10.1007/978-3-319-57127-0_3
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