Abstract
Repetitive transcranial magnetic stimulation (rTMS) is a non-pharmacological treatment that is associated with significant improvements in clinical symptoms of major depressive disorder (MDD). The efficacy of rTMS treatment can be predicted using pre-treatment cordance, a quantitative electroencephalography (QEEG) method extracting information from absolute and relative power of EEG spectra, that will prevent trial-and error treatment sequences, subject suffering and increase in health-care costs. In this study, pre-treatment QEEG data were collected from 6 frontal electrodes (Fp1, Fp2, F3, F4, F7 and F8) in slow bands (delta and theta) for 147 MDD subjects. In order to classify MDD subjects as responder or non-responder, four different machine learning techniques, which are Artificial Neural Networks (ANN), Support Vector Machines (SVM) and Decision Tree (DT), were used and their performances were evaluated. The results show that it is possible to predict rTMS treatment responders with a sensitivity of 95.6%, accuracy of 86.4% and area under Receiver Operating Characteristics (ROC) curve (AUC) value of 0.92 using SVM.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Trivedi, M., Morris, D., Grannemann, B., et al.: Symptom clusters as predictors of late response to antidepressant treatment. J. Clin. Psychiatry 66, 1064–1070 (2005)
Bares, M., Brunovsky, M., Novak, T., et al.: The change of prefrontal QEEG theta cordance as a predictor of response to bupropion treatment in patients who had failed to respond to previous antidepressant treatments. Eur. Neuropsychopharmacol. 20, 459–466 (2010)
O’Reardon, J., Solvason, H., et al.: Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatry 62, 1208–1216 (2007)
Im, C., Lee, C.: computer-aided performance evaluation of a multichannel transcranial magnetic stimulation system. IEEE Trans. Mag. 42, 3803–3808 (2006)
Price, G., Lee, J., Garvey, C.: Appraisal of sessional EEG features as a correlate of clinical changes in an rTMS treatment of depression. Clin. EEG Neurosci. 39, 131–138 (2008)
Micoulaud, J., Micoulaud-Franchi, J., Richieri, R.: Parieto-temporal alpha EEG band power at baseline as a predictor of antidepressant treatment response with repetitive transcranial magnetic stimulation: a preliminary study. J. Affect Disorders 137, 156–160 (2012)
Kito, S., Hasegawa, T., Koga, Y.: Cerebral blood flow ratio of the dorsolateral prefrontal cortex to the ventromedial prefrontal cortex as a potential predictor of treatment response to transcranial magnetic stimulation in depression. Brain Stimul. 5, 547–553 (2012)
Richieri, R., Boyer, L., Farisse, J., et al.: Predictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression. Eur. J. Nucl. Med. Mol. Imaging 38, 1715–1722 (2011)
Schachter, S., Holmes, G., Kasteleijn-Nolst Trenite, D.: Behavioral aspects of epilepsy: principles and practice demos, pp. 268–269. Medical Publishing (2007)
Khodayari, A., Reilly, J., Hasey, G.: Using pre-treatment electroencephalography data to predict response to transcranial magnetic stimulation therapy for major depression. In: 33rd Annual International Conference of the IEEE EMBS Boston, Massachusetts, USA, August, 2011
Khodayari, A., Hasey, G., Maccrimmon, D.: A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clin. Neurophysiol. 121, 1998–2006 (2010)
Bares, M., Brunovsky, M., Kopecek, M., et al.: Changes in QEEG prefrontal cordance as a predictor of response to antidepressants in patients with treatment resistant depressive disorder: a pilot study. J. Psychiatr. Res. 41, 319–325 (2007)
Yang, J., Singh, H., Hines, E., et al.: Channel selection and classification of electroencephalogram signals: an artificial neural network and genetic algorithm-based approach. Artif. Intell. Med. 55, 117–126 (2012)
Sriraam, N., Eswaran, C.: Performance evaluation of neural network and linear predictors for near-lossless compression of EEG signals. IEEE Trans. Inf Technol. Biomed. 12, 87–93 (2012)
Lima, C., Coelho, A.: Kernel machines for epilepsy diagnosis via EEG signal classification: A comparative study. Artif. Intell. Med. 53, 83–95 (2011)
Siuly, S., Li, Y.: Improving the separability of motor imagery EEG signals using a cross correlation-based least square support vector machine for brain-computer interface. IEEE Trans. Neural Syst. Rehabil. Eng. 20, 526–538 (2012)
Rivero, D., Guo, L., Seoane, J., et al.: Using genetic algorithms and k-nearest neighbour for automatic frequency band selection for signal classification. IET Sig. Process. 20, 186–194 (2012)
Trujillo-Barreto, N., Aubert-Vázquez, E., Penny, W.: Bayesian M/EEG source reconstruction with spatio-temporal priors. Neuroimage 39, 318–335 (2008)
Leuchter, A., Cook, I., Lufkin, R., et al.: Cordance: a new method for assessment of cerebral perfusion and metabolism using quantitative electroencephalography. Neuroimage 3, 208–219 (1994)
Leuchter, A., Uijtdehaage, S., Cook, I., et al.: Relationship between brain electrical activity and cortical perfusion in normal subjects. Psychiatry Res. 90, 125–140 (1999)
Tarhan, N., HizliSayar, G., Tan, O., et al.: Efficacy of high-frequency repetitive transcranial magnetic stimulation in treatment-resistant depression. Clin. EEG Neurosci. 43(4), 279–284 (2012)
Hamilton, M.: A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56–62 (2009)
Sivanandam, N., Sumathi, S., Deepa, S.: Introduction to Neural Networks using MATLAB 6.0, pp. 21–223. Tata McGraw-Hill Publishing company Limited, New Delhi (2008)
Lek, S., Guegan, J.: Artificial neural networks as a tool in ecological modelling, an introduction. Ecol. Model. 120, 65–73 (1999)
Boser, B., Guyon, I., Vapnik, V.: A training algorithm for optimal margin classifiers. In: Proceedings of the Fifth Annual Workshop on Computational Learning Theory, pp. 144–152 (1992)
Cortes, C., Vapnik, V.: Support-vector network. Mach. Learn. 20, 273–297 (1994)
Chang, C., Lin, C.: LIBSVM: A library for support vector machines. ACM Trans. Intell. Syst. Technol. 2, 1–27 (2011)
Goker, I., Osman, O., Ozekes, S., et al.: Classification of juvenile myoclonic epilepsy data acquired through scanning electromyography with machine learning algorithms. J. Med. Syst. 36, 2705–2711 (2012)
Cervantes, J., Lamont, F.G.: Data selection based on decision tree for SVM classification on large data sets. Appl. Soft Comput. 37, 787–798 (2015)
Hernanadez, J.: ROC curves for regression. Pattern Recogn. 46, 3395–3411 (2013)
Ling, C., Huang, J., Zhang, H.: AUC: a statistically consistent and more discriminating measure than accuracy. In: Proceedings of the 18th International Conference on Artificial Intelligence, IJCAI 2003, pp. 519–524 (2003)
Arns, M., Drinkenburg, W., Fitzgerald, G., et al.: Neurophysiological predictors of non-response to rTMS in depression. Brain Stimul. 5, 569–576 (2012)
Kito, S., Hasegawa, T., Koga, Y.: Cerebral blood flow ratio of the dorsolateral prefrontal cortex to the ventromedial prefrontal cortex as a potential predictor of treatment response to transcranial magnetic stimulation in depression. Brain Stimul. 5, 547–553 (2012)
Richieri, R., Boyer, L., Farisse, J., et al.: Predictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression. Eur. J. Nucl. Med. Mol. Imaging 38, 1715–1722 (2011)
Khodayari, A., Reilly, J., Hasey, G., et al.: Using pre-treatment electroencephalography data to predict response to transcranial magnetic stimulation therapy for major depression. In: 33rd Annual International Conference of the IEEE EMBS Boston, Massachusetts (2011)
Khodayari, A., Hasey, G., Maccrimmon, D., et al.: A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clin. Neurophysiol. 121, 1998–2006 (2010)
O’Reardon, J., Solvason, H., Janicak, P., et al.: Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatr. 62, 1208–1216 (2007)
Brakemeier, E., Wilbertz, G., Rodax, S.: Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: replication study in drug-free patients. J. Affect Disorders 108, 59–70 (2008)
Grazilla, O., William, P., Andre, M., et al.: Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review. Neurosci. Biobehav. R. 36, 1140–1152 (2012)
Acknowledgement
Authors would like to express their thanks to NPIstanbul Hospital for providing the required EEG data.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this paper
Cite this paper
Erguzel, T.T., Tarhan, N. (2018). Machine Learning Approaches to Predict Repetitive Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder. In: Bi, Y., Kapoor, S., Bhatia, R. (eds) Proceedings of SAI Intelligent Systems Conference (IntelliSys) 2016. IntelliSys 2016. Lecture Notes in Networks and Systems, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-56991-8_29
Download citation
DOI: https://doi.org/10.1007/978-3-319-56991-8_29
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-56990-1
Online ISBN: 978-3-319-56991-8
eBook Packages: EngineeringEngineering (R0)