Skip to main content
SpringerLink
Log in

Secondary Causes: Work-Up and Its Specificities in CKD: Influence of Arterial Stiffening

  • Chapter
  • First Online:
Resistant Hypertension in Chronic Kidney Disease

  • 756 Accesses

Abstract

The reciprocal induction and worsening relationship between hypertension (HTN) and chronic kidney disease (CKD) is well known and investigated for a long time. Increased arterial stiffness is a major nontraditional cardiovascular risk factor in CKD reflecting the difficulty of the large arteries to convert flow oscillations into continuous blood flow due to significant morphological changes induced by this pathological condition. Surrogate markers of cardiovascular disease used in CKD work-up include ankle-brachial index, carotid ultrasound (assessing carotid intima-media thickness and plaque), aortic pulse wave velocity, and the echocardiography quantification of the subclinical hypertensive heart disease (e.g., left ventricular mass, diastolic dysfunction). Current data support the idea that the integration of clinical characteristics (accurate measurement of blood pressure, 24-h ambulatory blood pressure monitoring, etc.) with information derived from arterial stiffness assessment may represent an accurate and cost-effective approach for individualizing CKD and HTN patients’ care and treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Amenos AC, Gonzalez-Juanatey JR, Gutierrez PC, Gilarranz AM, Costae CG. Prevalence of chronic kidney disease in patients with or at a high risk of cardiovascular disease. Rev Esp Cardiol. 2010;63(2):225–8.

    Article  Google Scholar 

  2. Hallan SI, Dahl K, Oien CM, et al. Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey. BMJ. 2006;333(7577):1047.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kes P, Milicić D, Basić-Jukić N. How to motivate nephrologists to think more “cardiac” and cardiologists to think more “renal”? Acta Med Croatica. 2011;65(Suppl 3):85–9.

    PubMed  Google Scholar 

  4. Kheder-Elfekih R, Yannoutsos A, Blacher J, London GM, Safar ME. Hypertension and chronic kidney disease: respective contribution of mean and pulse pressure and arterial stiffness. J Hypertens. 2015;31:[Epub ahead of print].

    Google Scholar 

  5. Agarwal R, Martinez-Castelao A, Wiecek A, Massy Z, Suleymanlar G, Ortiz A, Blankestijn PJ, Covic A, Dekker FW, Jager KJ, Lindholm B, Goldsmith D, Fliser D, London G, Zoccali C. EUropean REnal and CArdiovascular medicine working group of the European renal association–European dialysis and transplant association (ERA–EDTA). The lingering dilemma of arterial pressure in CKD: what do we know, where do we go? Kidney Int Suppl. 2011;1(1):17–20.

    Article  Google Scholar 

  6. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith SC Jr, Svetkey LP, Taler SJ, Townsend RR, Wright JT Jr, Narva AS, Ortiz E, MD. 2014 evidence-based guideline for the management of high blood pressure in adults report from the panel members appointed to the eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–20.

    Article  CAS  PubMed  Google Scholar 

  7. Covic A, Goldsmith D, Donciu M-D, Siriopol D, Popa R, Kanbay M, London G. From profusion to confusion: the Saga of managing hypertension in chronic kidney disease! J Clin Hypertens. 2015;17(6):421–7.

    Article  Google Scholar 

  8. Bangash F, Agarwal R. Masked hypertension and white-coat hypertension in chronic kidney disease: a meta-analysis. Clin J Am Soc Nephrol. 2009;4(3):656–64.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Rubin MF, Rosas SE, Chirinos JA, Townsend RR. Surrogate markers of cardiovascular disease in CKD: what’s under the hood? Am J Kidney Dis. 2011;57(3):488–97.

    Article  PubMed  Google Scholar 

  10. Covic A, Siriopol D. Pulse wave velocity ratio: the new “gold standard” for measuring arterial stiffness. Hypertension. 2015;65(2):289–90.

    Article  CAS  PubMed  Google Scholar 

  11. Boutouyrie P, Fliser D, Goldsmith D, Covic A, Wiecek A, Ortiz A, et al. Assessment of arterial stiffness for clinical and epidemiological studies: methodological considerations for validation and entry into the European renal and cardiovascular medicine registry. Nephrol Dial Transplant. 2014;29(2):232–9.

    Article  PubMed  Google Scholar 

  12. Jia G, Aroor AR, Sowers JR. Arterial stiffness: a nexus between cardiac and renal disease. Cardiorenal Med. 2014;4:60–71.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kullo IJ, Malik AR. Arterial ultrasonography and tonometry as adjuncts to cardiovascular risk stratification. J Am Coll Cardiol. 2007;49(13):1413–26.

    Article  PubMed  Google Scholar 

  14. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H, on behalf of the European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588–605.

    Article  PubMed  Google Scholar 

  15. Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’. Eur Heart J. 2010;31(19):2338–50.

    Article  Google Scholar 

  16. Kalaitzidis RG, Karasavvidou DP, Tatsioni A, Pappas K, Katatsis G, Liontos A, Elisaf MS. Albuminuria as a marker of arterial stiffness in chronic kidney disease patients. World J Nephrol. 2015;4(3):406–14.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Fortier C, Mac-Way F, Desmeules S, Marquis K, De Serres SA, Lebel M, Boutouyrie P, Agharazii M. Aortic-brachial stiffness mismatch and mortality in dialysis population. Hypertension. 2015;65(2):378–84.

    Article  CAS  PubMed  Google Scholar 

  18. Ma Y, Zhou L, Dong J, Zhang X, Yan S. Arterial stiffness and increased cardiovascular risk in chronic kidney disease. Int Urol Nephrol. 2015;47(7):1157–64.

    Article  CAS  PubMed  Google Scholar 

  19. Hashimoto J, Ito S. Central pulse pressure and aortic stiffness determine renal hemodynamics. Pathophysiological implication for microalbuminuria in hypertension. Hypertension. 2011;58(5):839–46.

    Article  CAS  PubMed  Google Scholar 

  20. Dhaun N, Moorhouse R, MacIntyre IM, Melville V, Oosthuyzen W, Kimmitt RA, Brown KE, Kennedy ED, Goddard J, Webb DJ. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease. The role of endothelin-1. Hypertension. 2014;64(2):296–304.

    Article  CAS  PubMed  Google Scholar 

  21. Mojón A, Ayala D, Piñeiro L, Otero A, Crespo JJ, Moyá A, Bóveda J, de Lis JP, Fernández JR, Hermida RC, on behalf of the Hygia Project Investigators. Comparison of ambulatory blood pressure parameters of hypertensive patients with and without chronic kidney disease. Chronobiol Int. 2012;30(1–2):145–58.

    PubMed  Google Scholar 

  22. Gismondi RA, Neves MF, Oigman W, Bregman R. Ambulatory arterial stiffness index is higher in hypertensive patients with chronic kidney disease. Int J Hypertens. 2012;2012:178078. doi:10.1155/2012/178078.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Elsurer R, Afsar B. Serum uric acid and arterial stiffness in hypertensive chronic kidney disease patients: sex-specific variations. Blood Press Monit. 2014;19(5):271–9.

    Article  PubMed  Google Scholar 

  24. Makris A, Seferou M, Papadopoulos DP. Resistant hypertension workup and approach to treatment. Int J Hypertens. 2011;2011:598694. doi:10.4061/2011/598694.

    Article  Google Scholar 

  25. Bellasi A, Ferramosca E, Ratti C. Arterial stiffness in chronic kidney disease: the usefulness of a marker of vascular damage. Int J Nephrol. 2011;2011:734832. doi:10.4061/2011/734832.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiology Clinic, “St. Spiridon” County Emergency Hospital Iaşi, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania

    Antoniu Octavian Petriş

Authors
  1. Antoniu Octavian Petriş
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Antoniu Octavian Petriş .

Editor information

Editors and Affiliations

  1. Grigore T. Popa University of Medicine, Iaşi, Romania

    Adrian Covic

  2. Department of Medicine, Division of Nephrology, University School of Medicine, Istanbul, Turkey

    Mehmet Kanbay

  3. Section of Nephrology, University of Illinois at Chicago College of Medicine/Advocate Christ Medical Center, Oak Lawn, Illinois, USA

    Edgar V. Lerma

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Petriş, A.O. (2017). Secondary Causes: Work-Up and Its Specificities in CKD: Influence of Arterial Stiffening. In: Covic, A., Kanbay, M., Lerma, E. (eds) Resistant Hypertension in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-56827-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-56827-0_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56825-6

  • Online ISBN: 978-3-319-56827-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation