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System Modeling of Receptor-Induced Apoptosis

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TRAIL, Fas Ligand, TNF and TLR3 in Cancer

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics ((RTACT,volume 12))

Abstract

Receptor-induced apoptosis is a complex signal transduction pathway involving numerous protein–protein interactions and post-translational modifications. The response to death receptor stimulation varies significantly from one cell line to another and even from one cell to another within a given cell line. In this context, it is often difficult to assess whether the molecular mechanisms identified so far are sufficient to explain the rich quantitative observations now available, and to detect possible gaps in our understanding. This is precisely where computational systems biology approaches may contribute. In this chapter, we review studies done in this direction, focusing on those that provided a significant insight on the functioning of this complex pathway by tightly integrating experimental and computational approaches.

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Acknowledgments

This work was supported by the research grants Syne2arti ANR-10-COSINUS-007 and Investissements d’Avenir Iceberg ANR-IABI-3096 from the French National Research Agency.

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Authors and Affiliations

  1. INRIA Paris, 2 rue Simone Iff, 75589, Paris cedex 12, France

    François Bertaux & Dirk Drasdo

  2. Department of Mathematics, Imperial College London, London, SW7 2AZ, UK

    François Bertaux

  3. Inria Saclay – Ile-de-France, 91120, Palaiseau, France

    François Bertaux & Grégory Batt

Authors
  1. François Bertaux
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  2. Dirk Drasdo
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  3. Grégory Batt
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Corresponding authors

Correspondence to François Bertaux or Grégory Batt .

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Editors and Affiliations

  1. INSERM, LNC UMR 1231, Dijon, France

    Olivier Micheau

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Bertaux, F., Drasdo, D., Batt, G. (2017). System Modeling of Receptor-Induced Apoptosis. In: Micheau, O. (eds) TRAIL, Fas Ligand, TNF and TLR3 in Cancer. Resistance to Targeted Anti-Cancer Therapeutics, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-56805-8_12

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