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Central Pain Syndrome pp 7–53Cite as

Epidemiology

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Abstract

When one considers neuropathic pain globally, 6.9%–10% of the entire population is affected [1].

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References

  1. van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(4):654–62.

    Article  PubMed  Google Scholar 

  2. Kameyama M. Vascular lesions of the thalamus on the dominant and nondominant side. Appl Neurophysiol. 1976–1977;39:171–7.

    Google Scholar 

  3. Graff-Radford NR, Damasio H, Yamada T, Eslinger PJ, Damasio AR. Nonhaemorrhagic thalamic infarction: clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. Brain. 1985;108:485–516.

    Article  PubMed  Google Scholar 

  4. Kawahara N, Sato K, Muraki M, Tanaka K, Kaneko M, Uemura K. CT classification of small thalamic hemorrhages and their clinical implications. Neurology. 1986;36(2):165–72.

    Article  CAS  PubMed  Google Scholar 

  5. Bogousslavsky J, Regli F, Uske A. Thalamic infarcts: clinical syndromes, etiology, and prognosis. Neurology. 1988;38:837–48. Erratum in Neurology. 1988;38:1335.

    Google Scholar 

  6. Kim JS. Pure sensory stroke. Clinical-radiological correlates of 21 cases. Stroke. 1992;23(7):983–7.

    Article  CAS  PubMed  Google Scholar 

  7. Samuelsson M, Samuelsson L, Lindell D. Sensory symptoms and signs and results of quantitative sensory thermal testing in patients with lacunar infarct syndromes. Stroke. 1994;25:2165–70.

    Article  CAS  PubMed  Google Scholar 

  8. Kumral E, Kocaer T, Ertübey N, Kumral K. Thalamic hemorrhage: a prospective study of 100 patients. Stroke. 1995;26:964–70.

    Article  CAS  PubMed  Google Scholar 

  9. Andersen G, Vestergaard K, Ingeman-Nielsen M, Jensen TS. Incidence of central post-stroke pain. Pain. 1995;61:187–93.

    Article  CAS  PubMed  Google Scholar 

  10. Naver H, Blomstrand C, Ekholm S, Jensen C, Karlsson T, Wallin G. Autonomic and thermal sensory symptoms and dysfunction after stroke. Stroke. 1995;26(8):1379–85.

    Article  CAS  PubMed  Google Scholar 

  11. Mori S, Sadoshima S, Ibayashi S, Fujishima M, Iino K. Impact of thalamic hematoma on six-month mortality and motor and cognitive functional outcome. Stroke. 1995;26:620–6.

    Article  CAS  PubMed  Google Scholar 

  12. Chung CS, Caplan LR, Han W, Pessin MS, Lee KH, Kim JM. Thalamic haemorrhage. Brain. 1996;119(Pt 6):1873–86.

    Article  PubMed  Google Scholar 

  13. Kim JS, Bae YH. Pure or predominant sensory stroke due to brain stem lesion. Stroke. 1997;28:1761–4.

    Article  CAS  PubMed  Google Scholar 

  14. Nasreddine ZS, Saver JL. Pain after thalamic stroke: right diencephalic predominance and clinical features in 180 patients. Neurology. 1997;48:1196–9.

    Article  CAS  PubMed  Google Scholar 

  15. MacGowan DJ, Janal MN, Clark WC, Wharton RN, Lazar RM, Sacco RL, Mohr JP. Central poststroke pain and Wallenberg’s lateral medullary infarction: frequency, character, and determinants in 63 patients. Neurology. 1997;49(1):120–5.

    Article  CAS  PubMed  Google Scholar 

  16. Paciaroni M, Bogousslavsky J. Pure sensory syndromes in thalamic stroke. Eur Neurol. 1998;39:211–7.

    Article  CAS  PubMed  Google Scholar 

  17. Bassetti C, Bogousslavsky J, Mattle H, Bernasconi A. Medial medullary stroke: report of seven patients and review of the literature.Neurology. 1997;48(4):882–90.

    Google Scholar 

  18. Kim JS, Choi-Kwon S. Sensory sequelae of medullary infarction: differences between lateral and medial medullary syndrome. Stroke. 1999;30:2697–703.

    Article  CAS  PubMed  Google Scholar 

  19. Mukherjee CS, Sarkhel A, Banerjee TK, Sen S. Community survey of central post-stroke pain (CPSP). In: 9th World Congress on Pain, Book of Abstracts, A338. Seattle, WA: IASP Press; 1999.

    Google Scholar 

  20. Kumral E, Evyapan D, Balkir K, Kutluhan S. Bilateral thalamic infarction: clinical, etiological and MRI correlates. Acta Neurol Scand. 2001;103:35–42.

    Article  CAS  PubMed  Google Scholar 

  21. Bowsher D. Stroke and central poststroke pain in an elderly population. J Pain. 2001;2:258–61.

    Article  CAS  PubMed  Google Scholar 

  22. Lampl C, Yazdi K, Roeper C. Amitriptyline in the prophylaxis of central post-stroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. Stroke. 2002;33:3030–2.

    Article  CAS  PubMed  Google Scholar 

  23. Weimar C, Kloke M, Schlott M, Katsarava Z, Diener HC. Central poststroke pain in a consecutive cohort of stroke patients. Cerebrovasc Dis. 2002;14:261–3.

    Article  PubMed  Google Scholar 

  24. Widar M, Samuelsson L, Karlsson-Tivenius S, Ahlstroem G. Long-term pain conditions after a stroke. J Rehabil Med. 2002;34:165–70.

    Article  PubMed  Google Scholar 

  25. Kim JS. Central post-stroke pain or paresthesia in lenticulocapsular hemorrhages. Neurology. 2003;61:679–82.

    Article  PubMed  Google Scholar 

  26. Gonzales GR, Tuttle SL, Thaler HT, Manfredi PL. Central pain in cancer patients. J Pain. 2003;4:351–4.

    Article  PubMed  Google Scholar 

  27. Kameda W, Kawanami T, Kurita K, Daimon M, Kayama T, Hosoya T, Kato T, Study Group of the Association of Cerebrovascular Disease in Tohoku. Lateral and medial medullary infarction: a comparative analysis of 214 patients. Stroke. 2004;35(3):694–9.

    Article  CAS  PubMed  Google Scholar 

  28. Kong KH, Woon VC, Yang SY. Prevalence of chronic pain and its impact on health-related quality of life in stroke survivors. Arch Phys Med Rehabil. 2004;85:35–40.

    Article  PubMed  Google Scholar 

  29. Nakazato Y, Yoshimaru K, Ohkuma A, Araki N, Tamura N, Shimazu K. [Central post-stroke pain in Wallenberg syndrome]. No To Shinkei. 2004;56(5):385–8. Japanese.

    Google Scholar 

  30. Widar M, Ek AC, Ahlstroem G. Coping with longterm pain after a stroke. J Pain Symptom Manage. 2004;27:215–25. (See also J Clin Nurs 2004; 13: 497–505).

    Article  PubMed  Google Scholar 

  31. Jonsson AC, Lindgren I, Hallstrom B, Norrving B, Lindgren A. Prevalence and intensity of pain after stroke: a population based study focusing on patients perspectives. J Neurol Neurosurg Psychiatry. 2006;77:590–5.

    Article  PubMed  Google Scholar 

  32. Appelros P. Prevalence and predictors of pain and fatigue after stroke: a population-based study. Int J Rehabil Res. 2006;29:329–33.

    Article  PubMed  Google Scholar 

  33. Choi-Kwon S, Choi JM, Kwon SU, Kang DW, Kim JS. Factors that affect the quality of life at 3years post-stroke. J Clin Neurol. 2006;2(1):34–41.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Kim JS, Han YS. Medial medullary infarction: clinical, imaging, and outcome study in 86 consecutive patients. Stroke. 2009;40(10):3221–5.

    Article  PubMed  Google Scholar 

  35. Lundstrom E, Smits A, Terent A, Borg J. Risk factors for stroke-related pain 1year after first-ever stroke. Eur J Pain. 2009;16:188–93.

    CAS  Google Scholar 

  36. Kuptniratsaikul V, Kovindha A, Suethanapornkul S, Manimmanakorn N, Archongka Y. Complications during the rehabilitation period in Thai patients with stroke: a multicenter prospective study. Am J Phys Med Rehabil. 2009;88:92–9.

    Article  PubMed  Google Scholar 

  37. Zvan B, Zaletel M. Ageing and poststroke pain. Eur J Pain. 2010;Suppl 4:107.

    Google Scholar 

  38. Zaletel M, Zvan B, Kobal J. Influence of age on central post-stroke pain. Eur J Pain. 2007;11(1 Suppl):140.

    Article  Google Scholar 

  39. Hamzat TK, Osundiya OC. Musculoskeletal pain and its impact on motor performance among stroke survivors. Hong Kong Physiother J. 2010;28:11–5.

    Article  Google Scholar 

  40. Klit H, Finnerup NB, Andersen G, Jensen TS. Central poststroke pain: a population-based study. Pain. 2011;152:818–24.

    Article  PubMed  Google Scholar 

  41. Klit H, Hansen AP, Finnerup NB, Jensen TS. Is early evoked dysaesthesia or allodynia a predictor of central post-stroke pain? Eur J Pain Suppl. 2011;5(1):239–40 (S261).

    Google Scholar 

  42. Klit H, Hansen AP, Marcussen NS, Finnerup NB, Jensen TS. Early evoked pain or dysesthesia is a predictor of central poststroke pain. Pain. 2014;155(12):2699–706.

    Article  PubMed  Google Scholar 

  43. Bugnicourt JM, Garcia PY, Canaple S, Lamy C, Godefroy O. Central neuropathic pain after cerebral venous thrombosis is not so uncommon: an observational study. J Neurol. 2011;258(6):1150–6.

    Article  PubMed  Google Scholar 

  44. Hokkoku K, Sonoo M, Murashima H, Iwanami T, Nishiyama K, Kawamura Y, Arai Y, Tsukamoto H, Hatanaka Y, Shimizu T. [Clinical features of predominantly sensory stroke due to brainstem infarction]. Rinsho Shinkeigaku. 2011;51(4):248–54.

    Google Scholar 

  45. Hong JH, Choi BY, Chang CH, Kim SH, Jung YJ, Lee DG, Kwon YH, Jang SH. The prevalence of central poststroke pain according to the integrity of the spino-thalamo-cortical pathway. Eur Neurol. 2012;67(1):12–7.

    Article  PubMed  Google Scholar 

  46. van Kollenburg EG, Lavrijsen JC, Verhagen SC, Zuidema SU, Schalkwijk A, Vissers KC. Prevalence, causes, and treatment of neuropathic pain in Dutch nursing home residents: a retrospective chart review. J Am Geriatr Soc. 2012;60(8):1418–25.

    Article  PubMed  Google Scholar 

  47. Hansen AP, Marcussen NS, Klit H, Andersen G, Finnerup NB, Jensen TS. Pain following stroke: a prospective study. Eur J Pain. 2012;16(8):1128–36.

    Article  CAS  PubMed  Google Scholar 

  48. Klit H, Finnerup NB, Jensen TS. Central post-stroke pain: clinical characteristics, pathophysiology, and management. Lancet Neurol. 2009;8(9):857–68.

    Google Scholar 

  49. De Oliveira RA, de Andrade DC, Machado AG, Teixeira MJ. Central poststroke pain: somatosensory abnormalities and the presence of associated myofascial pain syndrome. BMC Neurol. 2012;12:89.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Perchet C, Crombez A, Nighoghossian N, Garcia-Larrea L. LEPs as a predictive factor of neuropathic pain after brainstem stroke. Neurophysiol Clin. 2013;43:320–1.

    Article  Google Scholar 

  51. Li D, Zhang J, Hao S, Tang J, Xiao X, Wu Z, Zhang L. Surgical treatment and long-term outcomes of thalamic cavernous malformations. World Neurosurg. 2013;79(5–6):704–13.

    Article  PubMed  Google Scholar 

  52. O’Donnell MJ, Diener HC, Sacco RL, Panju AA, Vinisko R, Yusuf S, PRoFESS Investigators. Chronic pain syndromes after ischemic stroke: PRoFESS trial. Stroke. 2013;44(5):1238–43.

    Article  PubMed  Google Scholar 

  53. Raffaeli W, Minella CE, Magnani F, Sarti D. Population-based study of central post-stroke pain in Rimini district, Italy. J Pain Res. 2013;6:705–11.

    PubMed  PubMed Central  Google Scholar 

  54. Harno H, Haapaniemi E, Putaala J, Haanpää M, Mäkelä JP, Kalso E, Tatlisumak T. Central poststroke pain in young ischemic stroke survivors in the Helsinki Young Stroke Registry. Neurology. 2014;83(13):1147–54.

    Article  PubMed  Google Scholar 

  55. van Almenkerk S, Depla MF, Smalbrugge M, Eefsting JA, Hertogh CM. Pain among institutionalized stroke patients and its relation to emotional distress and social engagement. Int J Geriatr Psychiatry. 2015;30(10):1023–31.

    Article  PubMed  Google Scholar 

  56. Aprile I, Briani C, Pazzaglia C, Cecchi F, Negrini S, Padua L, Don Carlo Gnocchi Pain-Rehab Group. Pain in stroke patients: characteristics and impact on the rehabilitation treatment. A multicenter cross-sectional study. Eur J Phys Rehabil Med. 2015;51(6):725–36.

    CAS  PubMed  Google Scholar 

  57. Kumar A, Bhoi SK, Kalita J, Misra UK. Central poststroke pain can occur with normal sensation. Clin J Pain. 2016;32(11):955–60.

    Article  PubMed  Google Scholar 

  58. Paolucci S, Iosa M, Toni D, Barbanti P, Bovi P, Cavallini A, Candeloro E, Mancini A, Mancuso M, Monaco S, Pieroni A, Recchia S, Sessa M, Strambo D, Tinazzi M, Cruccu G, Truini A, Neuropathic pain special interest group of the Italian Neurological Society. Prevalence and time course of post-stroke pain: a multicenter prospective hospital-based study. Pain Med. 2016;17(5):924–30.

    PubMed  Google Scholar 

  59. Choi-Kwon S, Choi SH, Suh M, Choi S, Cho K-H, Nah H-W, Song H, Kim JS. Musculoskeletal and central pain at 1year post-stroke: associated factors and impact on quality of life. Acta Neurol Scand. 2017;135(4):419–25.

    Article  CAS  PubMed  Google Scholar 

  60. Burke D, Fullen BM, Stokes D, Lennon O. Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis. Eur J Pain. 2017;21(1):29–44.

    Article  CAS  PubMed  Google Scholar 

  61. Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord. 2014;52(2):110–6.

    Article  CAS  PubMed  Google Scholar 

  62. Jain NB, Ayers GD, Peterson EN, Harris MB, Morse L, O’Connor KC, Garshick E. Traumatic spinal cord injury in the United States, 1993–2012. JAMA. 2015;313(22):2236–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT. Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain. 2013;154(5):632–42.

    Article  PubMed  Google Scholar 

  64. Drulovic J, Basic-Kes V, Grgic S, Vojinovic S, Dincic E, Toncev G, Kezic MG, Kisic-Tepavcevic D, Dujmovic I, Mesaros S, Miletic-Drakulic S, Pekmezovic T. The prevalence of pain in adults with multiple sclerosis: a multicenter cross-sectional survey. Pain Med. 2015;16(8):1597–602.

    Article  PubMed  Google Scholar 

  65. Heitmann H, Biberacher V, Tiemann L, Buck D, Loleit V, Selter RC, Knier B, Tölle TR, Mühlau M, Berthele A, Hemmer B, Ploner M. Prevalence of neuropathic pain in early multiple sclerosis. Mult Scler. 2016;22(9):1224–30.

    Article  PubMed  Google Scholar 

  66. Roberto A, Deandrea S, Greco MT, Corli O, Negri E, Pizzuto M, Ruggeri F. Prevalence of neuropathic pain in cancer patients: pooled estimates from a systematic review of published literature and results from a survey conducted in 50 Italian palliative care centers. J Pain Symptom Manage. 2016;51(6):1091–102.e4.

    Article  PubMed  Google Scholar 

  67. Ravenscroft A, Ahmed YS, Burnside IG. Chronic pain after spinal cord injury: a survey of practice in UK spinal injury units. Spinal Cord. 1999;37:25–8.

    Article  CAS  PubMed  Google Scholar 

  68. Turner JA, Cardenas DD, Warms CA, Mc-Clellan CB. Chronic pain associated with spinal cord injuries: a community survey. Arch Phys Med Rehabil. 2001;82:501–8.

    Article  CAS  PubMed  Google Scholar 

  69. Barrett H, McClelland JM, Rutkowski SB, Siddall PJ. Pain characteristics in patients admitted to hospital with complications after spinal cord injury. Arch Phys Med Rehabil. 2003;84:789–95.

    Article  PubMed  Google Scholar 

  70. Norrbrink Budh C, Lund I, Hultling C, Levi R, Werhagen L, Ertzgaard P, Lundeberg T. Gender related differences in pain in spinal cord injured individuals. Spinal Cord. 2003;41(2):122–8.

    Article  CAS  PubMed  Google Scholar 

  71. Siddall PJ, McClelland JM, Rutkowski SB, Cousins MJ. A longitudinal study of the prevalence and characteristics of pain in the first 5years following spinal cord injury. Pain. 2003;103(3):249–57.

    Article  PubMed  Google Scholar 

  72. Cenzato M, Versari P, Righi C, Simionato F, Casali C, Giovanelli M. Spinal dural arteriovenous fistulae: analysis of outcome in relation to pretreatment indicators. Neurosurgery. 2004;55(4):815–22.

    Article  PubMed  Google Scholar 

  73. Henwood P, Ellis JA. Chronic neuropathic pain in spinal cord injury: the patient’s perspective. Pain Res Manag. 2004;9(1):39–45.

    Article  PubMed  Google Scholar 

  74. Werhagen L, Budh CN, Hultling C, Molander C. Neuropathic pain after traumatic spinal cord injury—relations to gender, spinal level, completeness, and age at the time of injury. Spinal Cord. 2004;42(12):665–73.

    Article  CAS  PubMed  Google Scholar 

  75. Werhagen L, Hultling C, Molander C. The prevalence of neuropathic pain after non-traumatic spinal cord lesion. Spinal Cord. 2007;45(9):609–15.

    Article  CAS  PubMed  Google Scholar 

  76. Ullrich PM, Jensen MP, Loeser JD, Cardenas DD. Pain intensity, pain interference and characteristics of spinal cord injury. Spinal Cord. 2008;46(6):451–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Saladino A, Atkinson JL, Rabinstein AA, Piepgras DG, Marsh WR, Krauss WE, Kaufmann TJ, Lanzino G. Surgical treatment of spinal dural arteriovenous fistulae: a consecutive series of 154 patients. Neurosurgery. 2010;67(5):1350–7.

    Article  PubMed  Google Scholar 

  78. Shinoyama M, Endo T, Takahash T, Shimizu H, Takahashi A, Suzuki M, Tominaga T. Long-term outcome of cervical and thoracolumbar dural arteriovenous fistulas with emphasis on sensory disturbance and neuropathic pain. World Neurosurg. 2010;73(4):401–8.

    Article  PubMed  Google Scholar 

  79. Heutink M, Post MW, Wollaars MM, van Asbeck FW. Chronic spinal cord injury pain: pharmacological and non-pharmacological treatments and treatment effectiveness. Disabil Rehabil. 2011;33(5):433–40.

    Article  PubMed  Google Scholar 

  80. Nakamura M, Tsuji O, Iwanami A, Tsuji T, Ishii K, Toyama Y, Chiba K, Matsumoto M. Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor. J Orthop Sci. 2012;17(4):352–7.

    Article  PubMed  Google Scholar 

  81. Robertson CE, Brown RD Jr, Wijdicks EF, Rabinstein AA. Recovery after spinal cord infarcts: long-term outcome in 115 patients. Neurology. 2012;78(2):114–21.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Salinas FA, Lugo LH, Garcıa HI. Efficacy of early treatment with carbamazepine in prevention of neuropathic pain in patients with spinal cord injury. Am J Phys Med Rehabil. 2012;91:1020–7.

    Article  PubMed  Google Scholar 

  83. Simon T, Niemann CA, Hero B, Henze G, Suttorp M, Schilling FH, Berthold F. Short- and long-term outcome of patients with symptoms of spinal cord compression by neuroblastoma. Dev Med Child Neurol. 2012;54(4):347–52.

    Article  PubMed  Google Scholar 

  84. Werhagen L, Aito S, Tucci L, Strayer J, Hultling C. 25years or more after spinal cord injury: clinical conditions of individuals in the Florence and Stockholm areas. Spinal Cord. 2012;50(3):243–6.

    Article  CAS  PubMed  Google Scholar 

  85. Zeilig G, Enosh S, Rubin-Asher D, Lehr B, Defrin R. The nature and course of sensory changes following spinal cord injury: predictive properties and implications on the mechanism of central pain. Brain. 2012;135(Pt 2):418–30.

    Article  PubMed  Google Scholar 

  86. Ataoğlu E, Tiftik T, Kara M, Tunç H, Ersöz M, Akkuş S. Effects of chronic pain on quality of life and depression in patients with spinal cord injury. Spinal Cord. 2013;51:23–6.

    Article  PubMed  Google Scholar 

  87. Finnerup NB, Norrbrink C, Trok K, Piehl F, Johannesen IL, Sørensen JC, Jensen TS, Werhagen L. Phenotypes and predictors of pain following traumatic spinal cord injury: a prospective study. J Pain. 2014;15(1):40–8.

    Article  PubMed  Google Scholar 

  88. Qing HS, Shuhui G, Jiagang L. Surgical management of intramedullary cavernous angiomas and analysis pain relief. Neurol India. 2014;62(4):423–8.

    Article  PubMed  Google Scholar 

  89. van Gorp S, Kessels AG, Joosten EA, van Kleef M, Patijn J. Pain prevalence and its determinants after spinal cord injury: a systematic review. Eur J Pain. 2015;19(1):5–14.

    Article  PubMed  Google Scholar 

  90. Sasamori T, Hida K, Osanai T, Yano S, Seki T, Houkin K. A survey of chronic pain due to spinal dural arteriovenous fistulae. Neurosurgery. 2015;77(1):113–8. Discussion 118.

    Article  PubMed  Google Scholar 

  91. Grabher P, Callaghan MF, Ashburner J, Weiskopf N, Thompson AJ, Curt A, Freund P. Tracking sensory system atrophy and outcome prediction in spinal cord injury. Ann Neurol. 2015;78(5):751–61.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Levitan Y, Zeilig G, Bondi M, Ringler E, Defrin R. Predicting the risk for central pain using the sensory components of the International Standards for Neurological Classification of Spinal Cord Injury. J Neurotrauma. 2015;32(21):1684–92.

    Article  PubMed  Google Scholar 

  93. Lee JK, Oh CH, Kim JY, Park HC, Yoon SH. Brain activation evoked by sensory stimulation in patients with spinal cord injury: functional magnetic resonance imaging correlations with clinical features. J Korean Neurosurg Soc. 2015;58(3):242–7.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Marcondes BF, Sreepathi S, Markowski J, Nguyen D, Stock SR, Carvalho S, Tate D, Zafonte R, Morse LR, Fregni F. Pain severity and mobility one year after spinal cord injury: a multicenter, cross-sectional study. Eur J Phys Rehabil Med. 2016;52(5):630–6.

    PubMed  Google Scholar 

  95. Nagoshi N, Kaneko S, Fujiyoshi K, Takemitsu M, Yagi M, Iizuka S, Miyake A, Hasegawa A, Machida M, Konomi T, Machida M, Asazuma T, Nakamura M. Characteristics of neuropathic pain and its relationship with quality of life in 72 patients with spinal cord injury. Spinal Cord. 2016;54(9):656–61.

    Article  CAS  PubMed  Google Scholar 

  96. Mahnig S, Landmann G, Stockinger L, Opsommer E. Pain assessment according to the International Spinal Cord Injury Pain classification in patients with spinal cord injury referred to a multidisciplinary pain center. Spinal Cord. 2016;54(10):809–15.

    Article  CAS  PubMed  Google Scholar 

  97. Andresen SR, Biering-Sørensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB. Pain, spasticity and quality of life in individuals with traumatic spinal cord injury in Denmark. Spinal Cord. 2016;54(11):973–9.

    Article  CAS  PubMed  Google Scholar 

  98. Finnerup NB, Jensen MP, Norrbrink C, Trok K, Johannesen IL, Jensen TS, Werhagen L. A prospective study of pain and psychological functioning following traumatic spinal cord injury. Spinal Cord. 2016;54(10):816–21.

    Article  CAS  PubMed  Google Scholar 

  99. Khazaeipour Z, Ahmadipour E, Rahimi-Movaghar V, Ahmadipour F, Vaccaro AR, Babakhani B. Association of pain, social support and socioeconomic indicators in patients with spinal cord injury in Iran. Spinal Cord. 2017;55:180–6.

    Article  CAS  PubMed  Google Scholar 

  100. Müller R, Brinkhof MW, Arnet U, Hinrichs T, Landmann G, Jordan X, Béchir M. Prevalence and associated factors of pain in the Swiss spinal cord injury population. Spinal Cord. 2017;55(4):346–54.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. HEAVEN/GEMINI International Collaborative Group, Turin, Italy

    Sergio Canavero

  2. AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi Montalcini, Università di Torino, Turin, Italy

    Vincenzo Bonicalzi

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Canavero, S., Bonicalzi, V. (2018). Epidemiology. In: Central Pain Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-56765-5_2

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