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Channel Blockers

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Central Pain Syndrome

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Abstract

The first recorded treatment of neuropathic pain with a sodium (Na+) channel blocker is probably Sigmund Freud’s treatment of Ernst von Fleischl’s trigeminal neuralgia with cocaine injections. Deisenhammer et al. [1] published the first Medline-indexed paper detailing the use of a Na+ channel blocker (carbamazepine) for CP (Tables 13.1, 13.2, 13.3, 13.4, 13.5, 13.6, 13.7, 13.8, 13.9, 13.10, 13.11, 13.12, 13.13, 13.14, 13.15, and 13.16).

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References

  1. Deisenhammer E, Scherrer H, Schnopfhagen O. [Carbamazepine in thalamic hyperpathia]. [Article in German]. Wien Med Wochenschr. 1969;119(25):475–6.

    CAS  PubMed  Google Scholar 

  2. Attal N, Gaudé V, Brasseur L, Dupuy M, Guirimand F, Parker F, Bouhassira D. Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study. Neurology. 2000;54(3):564–74.

    Article  CAS  PubMed  Google Scholar 

  3. Kvarnström A, Karlsten R, Quiding H, Gordh T. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury. Acta Anaesthesiol Scand. 2004;48(4):498–506.

    Article  PubMed  Google Scholar 

  4. Finnerup NB, Biering-Sørensen F, Johannesen IL, Terkelsen AJ, Juhl GI, Kristensen AD, Sindrup SH, Bach FW, Jensen TS. Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial. Anesthesiology. 2005;102(5):1023–30.

    Article  CAS  PubMed  Google Scholar 

  5. Sang C, Jenkins K, Wang K, Sarin A, Coccoli S. Fosphenytoin relieves central neuropathic pain following spinal cord injury. J Pain. 2006;7(Suppl 1):2 A312/692.

    Google Scholar 

  6. Mailis-Gagnon A, Yegneswaran B, Bharatwal B, Krassioukov AV. Effects of intravenous sodium amobarbital vs. lidocaine on pain and sensory abnormalities in patients with spinal cord injury. J Spinal Cord Med. 2009;32(1):49–53.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Leijon G, Boivie J. Central post-stroke pain—a controlled trial of amitriptyline and carbamazepine. Pain. 1989;36(1):27–36.

    Article  CAS  PubMed  Google Scholar 

  8. Salinas FA, Lugo LH, Garcıa HI. Efficacy of early treatment with carbamazepine in prevention of neuropathic pain in patients with spinal cord injury. Am J Phys Med Rehabil. 2012;91:1020–7.

    Article  PubMed  Google Scholar 

  9. Kalita J, Chandra S, Misra UK. Pregabalin and lamotrigine in central poststroke pain: A pilot study. Neurol India 2017;65(3): 506–511.

    Article  Google Scholar 

  10. Chiou-Tan FY, Tuel SM, Johnson JC, Priebe MM, Hirsh DD, Strayer JR. Effect of mexiletine on spinal cord injury dysesthetic pain. Am J Phys Med Rehabil. 1996;75(2):84–7.

    Article  CAS  PubMed  Google Scholar 

  11. Vestergaard K, Andersen G, Gottrup H, Kristensen BT, Jensen TS. Lamotrigine for central poststroke pain: a randomized controlled trial. Neurology. 2001;56(2):184–90.

    Article  CAS  PubMed  Google Scholar 

  12. Finnerup NB, Sindrup SH, Bach FW, Johannesen IL, Jensen TS. Lamotrigine in spinal cord injury pain: a randomized controlled trial. Pain. 2002;96(3):375–83.

    Article  CAS  PubMed  Google Scholar 

  13. Breuer B, Pappagallo M, Knotkova H, Guleyupoglu N, Wallenstein S, Portenoy RK. A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. Clin Ther. 2007;29(9):2022–30.

    Article  CAS  PubMed  Google Scholar 

  14. Silver M, Blum D, Grainger J, Hammer AE, Quessy S. Double-blind, placebo-controlled trial of lamotrigine in combination with other medications for neuropathic pain. J Pain Symptom Manag. 2007;34(4):446–54.

    Article  CAS  Google Scholar 

  15. Agarwal N, Joshi M. Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study. Spinal Cord. 2017;55(2):126–30 (in press).

    Google Scholar 

  16. Harden R, Houle T, Tyburski M, Tivedi K, Khan A, DiMaio A, Gagnon C. Levetiracetam in the management of neuropathic pain conditions: a double blind, randomized, crossover, placebo controlled pilot study using time series and hierarchical analysis. J Pain. 2006;7(4 Suppl):S34 (A727).

    Google Scholar 

  17. Finnerup NB, Grydehøj J, Bing J, Johannesen IL, Biering-Sørensen F, Sindrup SH, Jensen TS. Levetiracetam in spinal cord injury pain: a randomized controlled trial. Spinal Cord. 2009;47(12):861–7.

    Article  CAS  PubMed  Google Scholar 

  18. Rossi S, Mataluni G, Codecà C, Fiore S, Buttari F, Musella A, Castelli M, Bernardi G, Centonze D. Effects of levetiracetam on chronic pain in multiple sclerosis: results of a pilot, randomized, placebo-controlled study. Eur J Neurol. 2009;16(3):360–6.

    Article  CAS  PubMed  Google Scholar 

  19. Falah M, Madsen C, Holbech JV, Sindrup SH. A randomized, placebo-controlled trial of levetiracetam in central pain in multiple sclerosis. Eur J Pain. 2012;16(6):860–9.

    Article  CAS  PubMed  Google Scholar 

  20. Jungehulsing GJ, Israel H, Safar N, Taskin B, Nolte CH, Brunecker P, Wernecke KD, Villringer A. Levetiracetam in patients with central neuropathic post-stroke pain—a randomized, double-blind, placebo-controlled trial. Eur J Neurol. 2013;20(2):331–7.

    Article  CAS  PubMed  Google Scholar 

  21. Harden R, Brenman E, Saltz S, Houle T. Topiramate in the management of spinal cord injury pain: a double blind, randomised, placebo-controlled pilot study. Progr Pain Res Manage. 2002;23:393–407.

    Google Scholar 

  22. Boas RA, Covino BG, Shahnarian A. Analgesic responses to i.v. lignocaine. Br J Anaesth. 1982;54(5):501–5.

    Article  CAS  PubMed  Google Scholar 

  23. Backonja M, Gombar KA. Response of central pain syndromes to intravenous lidocaine. J Pain Symptom Manag. 1992;7(3):172–8.

    Article  CAS  Google Scholar 

  24. Edmondson EA, Simpson RK Jr, Stubler DK, Beric A. Systemic lidocaine therapy for poststroke pain. South Med J. 1993;86(10):1093–6.

    Article  CAS  PubMed  Google Scholar 

  25. Galer BS, Miller KV, Rowbotham MC. Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury. Neurology. 1993;43(6):1233–5.

    Article  CAS  PubMed  Google Scholar 

  26. Nagaro T, Shimizu C, Inoue H, Fujitani T, Adachi N, Amakawa K, Kimura S, Arai T, Watanabe T, Oka S. The efficacy of intravenous lidocaine on various types of neuropathic pain. Masui. 1995;44(6):862–7.

    CAS  PubMed  Google Scholar 

  27. Sakurai M, Kanazawa I. Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine. J Neurol Sci. 1999;162(2):162–8.

    Article  CAS  PubMed  Google Scholar 

  28. Trentin L, Visentin M. La predittività del test con lidocaina nel trattamento del dolore neuropatico. Minerva Anestesiol. 2000;66(3):157–61.

    CAS  PubMed  Google Scholar 

  29. Cahana A, Carota A, Montadon ML, Annoni JM. The long-term effect of repeated intravenous lidocaine on central pain and possible correlation in positron emission tomography measurements. Anesth Analg. 2004;98(6):1581–4.

    Article  CAS  PubMed  Google Scholar 

  30. Bharadwaj P, Danilychev M. Central post-stroke syndrome treated with parenteral lidocaine. J Pain Symptom Manag. 2006;32(5):400–1.

    Article  Google Scholar 

  31. Wasner G, Naleschinski D, Baron R. A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report. Pain. 2007;131(1–2):219–25.

    Article  PubMed  Google Scholar 

  32. Hans GH, Robert DN, Van Maldeghem KN. Treatment of an acute severe central neuropathic pain syndrome by topical application of lidocaine 5% patch: a case report. Spinal Cord. 2008;46(4):311–3.

    Article  CAS  PubMed  Google Scholar 

  33. Kern KU, Kohl M, Kiefer RT. Lidocain-Pflaster zur Therapie neuropatischer und nichtneuropatischer Schmerzen. Klinische Fallstudie an 87 patienten. Nervenarzt. 2010;81(12):1490–7.

    Article  PubMed  Google Scholar 

  34. Freo U, Ambrosio F, Furnari M, Ori C. Lidocaine 5% medicated plaster for spinal neuropathic pain. J Pain Palliat Care Pharmacother. 2016;30(2):111–3.

    Article  PubMed  Google Scholar 

  35. Awerbuch GI, Sandyk R. Mexiletine for thalamic pain syndrome. Int J Neurosci. 1990;55(2–4):129–33.

    Article  CAS  PubMed  Google Scholar 

  36. Bowsher D. La douleur neurogene. Doul Analg. 1994;7(2):65–9.

    Article  Google Scholar 

  37. Canavero S, Bonicalzi V. Mexiletine–gabapentin for central pain: an efficacy and long-term study. In: 11th world congress on pain, book of abstracts. Seattle: IASP Press; 2005. P-218 (A596 P-202).

    Google Scholar 

  38. Cardenas DD, Jensen MP. Treatments for chronic pain in persons with spinal cord injury: a survey study. J Spinal Cord Med. 2006;29(2):109–17.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Carroll IR, Kaplan KM, Mackey SC. Mexiletine therapy for chronic pain: survival analysis identifies factors predicting clinical success. J Pain Symptom Manag. 2008;35(3):321–6.

    Article  CAS  Google Scholar 

  40. Albert ML. Treatment of pain in multiple sclerosis—preliminary report. N Engl J Med. 1969;280(25):1395.

    Article  CAS  PubMed  Google Scholar 

  41. Espir ML, Millac P. Treatment of paroxysmal disorders in multiple sclerosis with carbamazepine (Tegretol). J Neurol Neurosurg Psychiatry. 1970;33(4):528–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Gibson JC, White LE Jr. Denervation hyperpathia: a convulsive syndrome of the spinal cord responsive to carbamazepine therapy. J Neurosurg. 1971;35(3):287–90.

    Article  CAS  PubMed  Google Scholar 

  43. Ekbom K. Carbamazepine in the treatment of tabetic lightning pains. Arch Neurol. 1972;26(4):374–8.

    Article  CAS  PubMed  Google Scholar 

  44. Giménez-Roldán S, Martín M. Tabetic lightning pains: high-dosage intravenous penicillin versus carbamazepine therapy. Eur Neurol. 1981;20(5):424–8.

    Article  PubMed  Google Scholar 

  45. Sandford PR, Lindblom LB, Haddox JD. Amitriptyline and carbamazepine in the treatment of dysesthesia pain in spinal cord injury. Arch Phys Medic Rehab. 1992;73(3):300–1.

    CAS  Google Scholar 

  46. Jenkins KR, Kaplan SE, Leahy L, Sang CN. Oxcarbazepine in central neuropathic pain with allodynia following spinal cord injury. Am Pain Soc Abstracts. 2002;3(2 Suppl):10 (A637).

    Google Scholar 

  47. Montes C, Magnin M, Maarrawi J, Frot M, Convers P, Mauguière F, Garcia-Larrea L. Thalamic thermo-algesic transmission: ventral posterior (VP) complex versus VMpo in the light of a thalamic infarct with central pain. Pain. 2005;113(1–2):223–32.

    Article  PubMed  Google Scholar 

  48. Solaro C, Restivo D, Mancardi GL, Tanganelli P. Oxcarbazepine for treating paroxysmal painful symptoms in multiple sclerosis: a pilot study. Neurol Sci. 2007;28(3):156–8.

    Article  CAS  PubMed  Google Scholar 

  49. Min K, Oh Y, Lee SH, Ryu JS. Symptom-based treatment of neuropathic pain in spinal cord-injured patients: a randomized crossover clinical trial. Am J Phys Med Rehabil. 2016;95(5):330–8.

    PubMed  Google Scholar 

  50. Fine W. Post-hemiplegic epilepsy in the elderly. Br Med J. 1967;1(5534):199–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Cantor FK. Phenytoin treatment of thalamic pain. Br Med J. 1972;4(5840):590.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Mladinich EK. Letter: Diphenylhydantoin in the Wallenberg syndrome. JAMA. 1974;230(3):372–3.

    Article  CAS  PubMed  Google Scholar 

  53. Agnew DC, Goldberg VD. A brief trial of phenytoin therapy for thalamic pain. Bull Los Angel Neurol Soc. 1976;41(1):9–12.

    CAS  Google Scholar 

  54. Canavero S, Bonicalzi V. Lamotrigine control of central pain. Pain. 1996;68(1):179–81.

    Article  CAS  PubMed  Google Scholar 

  55. Carrieri PB, Provitera VV, Lavorgna L, Bruno R. Response of thalamic pain syndrome to lamotrigine. Eur J Neurol. 1998;5(6):625–6.

    Article  CAS  PubMed  Google Scholar 

  56. McCleane G. Lamotrigine can reduce neurogenic pain associated with multiple sclerosis. Clin J Pain. 1998;14(3):269–70.

    Article  CAS  PubMed  Google Scholar 

  57. McCleane GJ. A prospective audit of the use of lamotrigine in 300 chronic pain patients. Pain Clin. 1998;11:97–102.

    Google Scholar 

  58. Cianchetti C, Zuddas A, Randazzo AP, Perra L, Marrosu MG. Lamotrigine adjunctive therapy in painful phenomena in MS: preliminary observations. Neurology. 1999;53(2):433.

    Article  CAS  PubMed  Google Scholar 

  59. Van Bastelaere M, De Laat M. Lamotrigine: a morphine-sparing drug for central pain. In: 9th world congress on pain, book of abstracts. Seattle: IASP Press; 1999. p. A211–P65.

    Google Scholar 

  60. Petramfar P, Nikseresht AR, Yaghoubi E. The effects of lamotrigine on pain, sleep, and mood in refractory form of central post-stroke pain syndrome. Iran J Med Sci. 2010;35:299–303.

    Google Scholar 

  61. D’Aleo G, Sessa E, Di Bella P, Rifici C, Restivo DA, Bramanti P. Topiramate modulation of R3 nociceptive reflex in multiple sclerosis patients suffering paroxysmal symptoms. J Neurol. 2001;248(11):996–9.

    Article  PubMed  Google Scholar 

  62. Canavero S, Bonicalzi V, Paolotti R. Lack of effect of topiramate for central pain. Neurology. 2002;58(5):831–2.

    Article  CAS  PubMed  Google Scholar 

  63. Calabrò RS, Marra A, Quattrini F, Gervasi G, Levita A, Bramanti P. Central neuropathic pain: an unusual case of painful ejaculation responding to topiramate. J Sex Med. 2012;9(12):3274–8.

    Article  PubMed  Google Scholar 

  64. Siniscalchi A, Gallelli L, De Sarro G. Effects of topiramate on dysaesthetic pain in a patient with multiple sclerosis. Clin Drug Investig. 2013;33(2):151–4.

    Article  PubMed  Google Scholar 

  65. Mori F, Codecà C, Kusayanagi H, Monteleone F, Buttari F, Fiore S, Bernardi G, Koch G, Centonze D. Effects of anodal transcranial direct current stimulation on chronic neuropathic pain in patients with multiple sclerosis. J Pain. 2010;11(5):436–42.

    Article  PubMed  Google Scholar 

  66. Takahashi Y, Hashimoto K, Tsuji S. Successful use of zonisamide for central poststroke pain. J Pain. 2004;5(3):192–4.

    Article  PubMed  Google Scholar 

  67. García-Escrivá A, López-Hernández N, Gil-Cortés C. Tratamiento del dolor neuropático con lacosamida. Rev Neurol. 2012;54:167–72.

    PubMed  Google Scholar 

  68. Dib-Hajj SD, Yang Y, Black JA, Waxman SG. The Na(V)1.7 sodium channel: from molecule to man. Nat Rev Neurosci. 2013;14(1):49–62.

    Article  CAS  PubMed  Google Scholar 

  69. Dib-Hajj SD, Black JA, Waxman SG. NaV1.9: a sodium channel linked to human pain. Nat Rev Neurosci. 2015;16(9):511–9.

    Article  CAS  PubMed  Google Scholar 

  70. Han C, Huang J, Waxman SG. Sodium channel Nav1.8: emerging links to human disease. Neurology. 2016;86(5):473–83.

    Article  CAS  PubMed  Google Scholar 

  71. Tanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD. A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia. Mol Med. 2016;22:338–48.

    Google Scholar 

  72. Gould HJ III, Diamond I. Ranolazine: a potential treatment for refractory neuropathic pain. Ranolazine: a potential treatment for refractory neuropathic pain. J Neurol Sci. 2016;369:310–1.

    Article  CAS  PubMed  Google Scholar 

  73. Hutson P, Backonja M, Knurr H. Intravenous lidocaine for neuropathic pain: a retrospective analysis of tolerability and efficacy. Pain Med. 2015;16(3):531–6.

    Article  PubMed  Google Scholar 

  74. Mooney JJ, Pagel PS, Kundu A. Safety, tolerability, and short-term efficacy of intravenous lidocaine infusions for the treatment of chronic pain in adolescents and young adults: a preliminary report. Pain Med. 2014;15(5):820–5.

    Article  PubMed  Google Scholar 

  75. Niki Y, Kanai A, Hoshi K, Okamoto H. Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia. Pain Med. 2014;15(5):826–31.

    Article  PubMed  Google Scholar 

  76. Wang XQ, Lv B, Wang HF, Zhang X, Yu SY, Huang XS, Zhang JT, Tian CL, Lang SY. Lamotrigine-induced severe cutaneous adverse reaction: update data from 1999–2014. J Clin Neurosci. 2015;22(6):1005–11.

    Article  CAS  PubMed  Google Scholar 

  77. Hussami A, Fromont A, Moreau T. Recidive de nevralgies du trijumeau sous fampridine. Rev Neurol (Paris). 2015;171:A71.

    Article  Google Scholar 

  78. Ratté S, Prescott SA. Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy. Curr Opin Neurobiol. 2016;36:31–7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. HEAVEN/GEMINI International Collaborative Group, Turin, Italy

    Sergio Canavero

  2. AOUCittà della Salute e della Scienza di Torino, Department of Neurosciences, Rita Levi Montalcini, Università di Torino, Turin, Italy

    Vincenzo Bonicalzi

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  1. Sergio Canavero
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  2. Vincenzo Bonicalzi
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Canavero, S., Bonicalzi, V. (2018). Channel Blockers. In: Central Pain Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-56765-5_13

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  • DOI: https://doi.org/10.1007/978-3-319-56765-5_13

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