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Breast Cancer Management for Surgeons pp 511–520Cite as

Breast Cancer in Special Groups: Breast Cancer in Pregnancy

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Abstract

Breast cancer is one of the most frequently diagnosed malignancies among pregnant women. Breast cancer diagnosed during pregnancy (BCP) remains a feared and challenging situation facing both patients and their treating physicians. Since abortion does not improve patients’ prognosis, correct management of this critical clinical situation is crucial. Specific guidelines have been developed to help physicians in managing patients with BCP. The present chapter aims to review the management of women with BCP, focusing on diagnosis and staging, local and systemic treatments, obstetric care and long-term follow-up of children with prenatal exposure to anticancer treatments.

Matteo Lambertini acknowledges the support from the European Society for Medical Oncology (ESMO) for a Translational Research Fellowship at Institut Jules Bordet

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Abbreviations

5-HT3 :

5-Hydroxytryptamine-3

AC:

Doxorubicin and cyclophosphamide

ASCO:

American Society of Clinical Oncology

BCP:

Breast cancer during pregnancy

BCY2:

Second International Consensus Guidelines for Breast Cancer in Young Women

CI:

Confidence intervals

EC:

Epirubicin and cyclophosphamide

ESMO:

European Society for Medical Oncology

FAC:

5-Fluorouracil, doxorubicin and cyclophosphamide

G-CSF:

Granulocyte colony-stimulating factors

MRI:

Magnetic resonance imaging

NEPA:

Netupitant and palonosetron

NK1:

Neurokinin 1

PABC:

Pregnancy-associated breast cancer

pHR:

Pooled hazard ratio

SLNB:

Sentinel lymph node biopsy

TNBC:

Triple-negative breast cancer

US:

United States

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Authors and Affiliations

  1. Department of Medical Oncology, U.O. Oncologia Medica 2, IRCCS AOU San Martino – IST, Largo Rosanna Benzi 10, 16132, Genoa, Italy

    Matteo Lambertini MD

  2. BrEAST Data Centre, Department of Medicine, Institut Jules Bordet, and l’Université Libre de Bruxelles (U.L.B.), Boulevard de Waterloo 121, 1000, Brussels, Belgium

    Matteo Lambertini MD & Hatem A. Azim Jr MD, PhD

  3. Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy

    Fedro Alessandro Peccatori MD, PhD

Authors
  1. Matteo Lambertini MD
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  2. Hatem A. Azim Jr MD, PhD
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  3. Fedro Alessandro Peccatori MD, PhD
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Correspondence to Fedro Alessandro Peccatori MD, PhD .

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Editors and Affiliations

  1. The Medical School Department of Oncology, University of Sheffield, Sheffield, United Kingdom

    Lynda Wyld

  2. Athens University Medical School, Athens, Greece

    Christos Markopoulos

  3. Helsinki University Hospital, Helsinki, Finland

    Marjut Leidenius

  4. Department of Oncology & Radiotherapy, Gdańsk Medical University Department of Oncology & Radiotherapy, Gdańsk, Poland

    Elżbieta Senkus-Konefka

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Lambertini, M., Azim, H.A., Peccatori, F.A. (2018). Breast Cancer in Special Groups: Breast Cancer in Pregnancy. In: Wyld, L., Markopoulos, C., Leidenius, M., Senkus-Konefka, E. (eds) Breast Cancer Management for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-56673-3_42

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