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Effect of Oestrogen Exposure, Obesity, Exercise and Diet on Breast Cancer Risk

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Abstract

Intense research efforts have been devoted to the exploration of breast cancer risk factors aiming at subsequent use in the development of prevention strategies. Age at menarche/menopause and childbearing patterns are proxies of exposure to endogenous oestrogens; circulating hormone levels, depending also on the use of exogenous oestrogens, are involved in the causation of the disease due to proliferative effects on breast epithelial tissue. Several modifiable lifestyle-related risk factors have been identified including obesity, alcohol consumption and physical inactivity, which increase breast cancer risk, especially in postmenopausal women, by up to 40%. Findings regarding the effect of diet remain inconclusive, apart from the established linear association of alcohol consumption with breast cancer risk. Exploration of specific components and the impact of these factors on disease outcome remains also to be established.

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Authors and Affiliations

  1. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias St, 11527, Athens, Greece

    Eleni Th. Petridou MD, MPH, PhD, Marios K. Georgakis MD & Constantine N. Antonopoulos MD, PhD

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  1. Eleni Th. Petridou MD, MPH, PhD
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  2. Marios K. Georgakis MD
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  3. Constantine N. Antonopoulos MD, PhD
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Correspondence to Eleni Th. Petridou MD, MPH, PhD .

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Editors and Affiliations

  1. The Medical School Department of Oncology, University of Sheffield, Sheffield, United Kingdom

    Lynda Wyld

  2. Athens University Medical School, Athens, Greece

    Christos Markopoulos

  3. Helsinki University Hospital, Helsinki, Finland

    Marjut Leidenius

  4. Department of Oncology & Radiotherapy, Gdańsk Medical University Department of Oncology & Radiotherapy, Gdańsk, Poland

    Elżbieta Senkus-Konefka

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Petridou, E.T., Georgakis, M.K., Antonopoulos, C.N. (2018). Effect of Oestrogen Exposure, Obesity, Exercise and Diet on Breast Cancer Risk. In: Wyld, L., Markopoulos, C., Leidenius, M., Senkus-Konefka, E. (eds) Breast Cancer Management for Surgeons. Springer, Cham. https://doi.org/10.1007/978-3-319-56673-3_4

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  • DOI: https://doi.org/10.1007/978-3-319-56673-3_4

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