Abstract
The term “cancer of unknown primary” refers to a condition in which a patient has metastatic malignancy without an identified primary source. The majority of patients have malignancy which appears to derive from epithelial cells and hence are regarded as having carcinoma of unknown primary. Cancer of unknown primary (CUP) is diagnosed following histological confirmation of malignancy with no obvious primary after a detailed history, examination and investigations. It occurs in 4–5% of patients presenting with invasive cancer [1].
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References
Greco FA, Hainsworth JD. Introduction: unknown primary cancer. Semin Oncol. 2009;36(1):6–7.
Data provided by the Office for National Statistics on request, July 2013. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
Hemminiki K, Liu H, Hemminiki A, et al. Power and limits of modern cancer diagnostics: cancer of unknown primary. Ann Oncol. 2012;23(3):760–4.
Stella GM, Senetta R, Cassenti A, et al. Cancers of unknown primary origin: current perspectives and future therapeutic strategies. J Transl Med. 2012;10:12.
Oien KA. Pathologic evaluation of unknown primary cancer. Semin Oncol. 2009;36:8–37.
Hainsworth JD, Fizazi K. Treatment for patients with unknown primary cancer and favourable prognostic factors. Semin Oncol. 2009;36:44–51.
Varadhachary GR. Carcinoma of unknown primary: focused evaluation. J Natl Compr Cancer Netw. 2011;9:1406–12.
Ettinger DS, Agulnik M, Cates JM, et al. NCCN clinical practice guidelines in oncology: occult primary. J Natl Compr Cancer Netw. 2011;9:1358–95.
Hemmeiniki K, Bevier M, Hemminki A, et al. Survival in cancer of unknown primary site: population based analysis by site and histology. Ann Oncol. 2011;23(7):1854–63.
Chen KW, Liu CJ, Lu HJ, et al. Evaluation of prognostic factors and the role of chemotherapy in unfavourable carcinoma of unknown primary site: a 10-year cohort study. BMC Res Notes. 2012;5:70.
Culine S. Prognostic factors in unknown primary cancer. Semin Oncol. 2009;36:60–4.
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Eswar, C. (2017). Cancer of Unknown Primary (CUP). In: Seshadri, N., Eswar, C. (eds) PET/CT in Cancer of Unknown Primary. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-56424-1_1
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DOI: https://doi.org/10.1007/978-3-319-56424-1_1
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