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Structure, Dynamics, and Modulation of Metabotropic Glutamate Receptors

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mGLU Receptors

Part of the book series: The Receptors ((REC,volume 31))

Abstract

The metabotropic glutamate receptors (mGluRs) are glutamate-activated G-protein-coupled receptors that are expressed throughout the central nervous system. The eight mGluR subtypes serve to modulate transmission at many synapses and are potential therapeutic targets for the treatment of many neurological and psychiatric diseases. In particular, their organization in multiple domains and subunits offers various possibilities for the development of new drugs that modulate mGluR activity. This review will show how recent and original approaches to study the mGluR structure, dynamics, and pharmacology have brought a new view of their mechanism of activation and the possibility of developing innovative ligands, such as light-regulated drugs, to control the physiological activity of mGluRs in animals.

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Acknowledgments

We would like to thanks Dr. Francine Acher for providing the mGlu4 receptor figure with chloride. This work was supported by grants from the Agence Nationale de la Recherche (ANR-09-PIRI-0011, ANR-09-BIOT-018 and ANR-13-BSV5-0007), the FRM (Equipe FRM DEQ20130326522) and Fondation Bettencourt Schueller. X.R. received a financial support from the Beatriu de Pinós program of Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR).

Conflict of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. CNRS, UMR5203, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094, Montpellier, France

    Philippe Rondard, Xavier Rovira, Cyril Goudet & Jean-Philippe Pin

  2. INSERM U1191, Montpellier, France

    Philippe Rondard, Xavier Rovira, Cyril Goudet & Jean-Philippe Pin

  3. Université de Montpellier, Montpellier, F-34000, France

    Philippe Rondard, Xavier Rovira, Cyril Goudet & Jean-Philippe Pin

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  1. Philippe Rondard
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  2. Xavier Rovira
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  3. Cyril Goudet
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  4. Jean-Philippe Pin
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Corresponding author

Correspondence to Philippe Rondard .

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Editors and Affiliations

  1. Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Richard Teke Ngomba

  2. Department of Physiology and Biochemistry, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  3. Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Giuseppe Battaglia

  4. Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

    Ferdinando Nicoletti

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Rondard, P., Rovira, X., Goudet, C., Pin, JP. (2017). Structure, Dynamics, and Modulation of Metabotropic Glutamate Receptors. In: Ngomba, R., Di Giovanni, G., Battaglia, G., Nicoletti, F. (eds) mGLU Receptors. The Receptors, vol 31. Humana Press, Cham. https://doi.org/10.1007/978-3-319-56170-7_7

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