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Metabotropic Glutamate Receptors and Parkinson’s Disease: Basic and Preclinical Neuroscience

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mGLU Receptors

Part of the book series: The Receptors ((REC,volume 31))

Abstract

Since the late 1990s, data from various laboratories have provided strong evidence that the three groups of mGlu receptors are widely and specifically expressed in the basal ganglia (BG), where they modulate neuronal excitability as well as synaptic transmission and plasticity. Therefore, targeting specific mGlu receptor subtypes by means of selective drugs could be a possible strategy for restoring normal synaptic function and neuron activity in the BG in Parkinson’s disease (PD). In this context, the spectacular development of subtype-selective mGlu receptor agonists, antagonists, and allosteric modulators has provided scientists with a wide range of neuropharmacological tools that have largely supported this hypothesis. This review provides data showing that drugs acting on mGlu receptors can alleviate PD motor symptoms and reduce levodopa-induced dyskinesia in animal models of PD and recent clinical trials that confirm these findings.

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Authors and Affiliations

  1. Aix-Marseille University, CNRS, UMR7288 Institut de Biologie du Développement de Marseille (IBDM), Case 907 Parc Scientifique de Luminy, 163 Avenue de Luminy, 13288, Marseille cedex 9, France

    Paolo Gubellini Ph.D.

  2. Department of Medical Neurobiology, Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem, Israel, 91120

    Liliya Iskhakova

  3. Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30329, USA

    Liliya Iskhakova & Yoland Smith Ph.D.

  4. Department of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Yoland Smith Ph.D.

  5. NIH UDALL Center of Excellence for Parkinson’s Disease Research, Emory University, Atlanta, GA, 30322, USA

    Yoland Smith Ph.D.

  6. Aix-Marseille University, CNRS, UMR7291, FR3C 3512, Laboratoire de Neurosciences Cognitives, 3 place Victor-Hugo, 13331, Marseille cedex 3, France

    Marianne Amalric Ph.D.

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  1. Paolo Gubellini Ph.D.
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  2. Liliya Iskhakova
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  3. Yoland Smith Ph.D.
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  4. Marianne Amalric Ph.D.
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Correspondence to Paolo Gubellini Ph.D. .

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  1. Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Richard Teke Ngomba

  2. Department of Physiology and Biochemistry, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  3. Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Giuseppe Battaglia

  4. Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

    Ferdinando Nicoletti

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Gubellini, P., Iskhakova, L., Smith, Y., Amalric, M. (2017). Metabotropic Glutamate Receptors and Parkinson’s Disease: Basic and Preclinical Neuroscience. In: Ngomba, R., Di Giovanni, G., Battaglia, G., Nicoletti, F. (eds) mGLU Receptors. The Receptors, vol 31. Humana Press, Cham. https://doi.org/10.1007/978-3-319-56170-7_3

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