Skip to main content
SpringerLink
Log in

Regulation of Hippocampal mGluR-Dependent Long-Term Depression by GluA2-Dependent Cofilin-Mediated Actin Remodeling

  • Chapter
  • First Online:
mGLU Receptors

Part of the book series: The Receptors ((REC,volume 31))

Abstract

The AMPA glutamate receptors (AMPARs) are the principal mediators of the fast excitatory synaptic transmission, and they are important for various forms of synaptic plasticity. The GluA2 subunit of AMPARs is particularly interesting because it controls a number of key properties of AMPARs, including Ca2+ permeability and receptor trafficking. In this chapter, we will discuss the critical involvement of GluA2 in mGluR-dependent long-term depression (mGluR-LTD) at the hippocampal CA1 synapse. We will summarize the data showing that GluA2 is essential for the expression of mGluR-LTD, but interestingly, the contribution of GluA2 in this form of LTD requires GluA2 N-terminal domain and its interaction with N-cadherin. In addition, we will evaluate the role of cofilin and its upstream regulator LIMK1 in mGluR-LTD and associated spine plasticity. Finally we will discuss interactions between GluA2 and LIMK1/cofilin and propose a molecular model to coordinate structural and functional plasticity through GluA2-dependent, cofilin-mediated actin remodeling.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aizawa H, Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I (2001) Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci 4:367–373

    Article  CAS  PubMed  Google Scholar 

  • Alvarez VA, Sabatini BL (2007) Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 30:79–97

    Article  CAS  PubMed  Google Scholar 

  • Andrianantoandro E, Pollard TD (2006) Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol Cell 24:187–195

    Article  Google Scholar 

  • Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805–809

    Article  CAS  PubMed  Google Scholar 

  • Asrar S, Meng Y, Zhou Z, Todorovski Z, Huang WW, Jia Z (2009a) Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1). Neuropharmacology 56:73–80

    Article  CAS  PubMed  Google Scholar 

  • Asrar S, Zhou Z, Ren W, Jia Z (2009b) Ca-permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II. PLoS One 4:e4339

    Article  PubMed  PubMed Central  Google Scholar 

  • Bamburg JR (1999) Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol 15:185–230

    Article  CAS  PubMed  Google Scholar 

  • Bamji SX (2005) Cadherins: actin with the cytoskeleton to form synapses. Neuron 47:175–178

    Article  CAS  PubMed  Google Scholar 

  • Bellenchi GC, Gurniak CB, Perlas E, Middei S, Ammassari-Teule M, Witke W (2007) N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev 21:2347–2357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bernard O (2007) Lim kinases, regulators of actin dynamics. Int J Biochem Cell Biol 39:1071–1076

    Article  CAS  PubMed  Google Scholar 

  • Bernstein BW, Bamburg JR (2010) ADF/cofilin: a functional node in cell biology. Trends Cell Biol 20:187–195

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bosch M, Castro J, Saneyoshi T, Matsuno H, Sur M, Hayashi Y (2014) Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron 82:444–459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bourne JN, Harris KM (2008) Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci 31:47–67

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bredt DS, Nicoll RA (2003) AMPA receptor trafficking at excitatory synapses. Neuron 40:361–379

    Article  CAS  PubMed  Google Scholar 

  • Carlisle HJ, Kennedy MB (2005) Spine architecture and synaptic plasticity. Trends Neurosci 28:182–187

    Article  CAS  PubMed  Google Scholar 

  • Chen LY, Rex CS, Casale MS, Gall CM, Lynch G (2007) Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci 27:5363–5372

    Article  CAS  PubMed  Google Scholar 

  • Cingolani LA, Goda Y (2008) Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. Nat Rev Neurosci 9:344–356

    Article  CAS  PubMed  Google Scholar 

  • Collingridge GL, Isaac JT, Wang YT (2004) Receptor trafficking and synaptic plasticity. Nat Rev Neurosci 5:952–962

    Article  CAS  PubMed  Google Scholar 

  • Collingridge GL, Olsen RW, Peters J, Spedding M (2009) A nomenclature for ligand-gated ion channels. Neuropharmacology 56:2–5

    Article  CAS  PubMed  Google Scholar 

  • Collingridge GL, Peineau S, Howland JG, Wang YT (2010) Long-term depression in the CNS. Nat Rev Neurosci 11:459–473

    Article  CAS  PubMed  Google Scholar 

  • Correˆa SA, Eales KL (2012) The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease. J Signal Transduct 2012(6):649079

    Google Scholar 

  • DesMarais V, Ghosh M, Eddy R, Condeelis J (2005) Cofilin takes the lead. J Cell Sci 118:19–26

    Article  CAS  PubMed  Google Scholar 

  • Dölen G, Bear MF (2008) Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J Physiol 586:1503–1508

    Article  PubMed  Google Scholar 

  • Eales KL, Palygin O, O'Loughlin T, Rasooli-Nejad S, Gaestel M, Müller J, Collins DR, Pankratov Y, Corrêa SA (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun 19(5):4701

    Article  Google Scholar 

  • Eibert SM, Lee KH, Pipkorn R, Sester U, Wabnitz GH, Giese T, Meuer SC, Samstag Y (2004) Cofilin peptide homologs interfere with immunological synapse formation and T cell activation. Proc Natl Acad Sci U S A 101:1957–1962

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Elia LP, Yamamoto M, Zang K, Reichardt LF (2006) p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron 51:43–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Engert F, Bonhoeffer T (1999) Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399:66–70

    Article  CAS  PubMed  Google Scholar 

  • Fedulov V, Rex CS, Simmons DA, Palmer L, Gall CM, Lynch G (2007) Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. J Neurosci 27:8031–8039

    Article  CAS  PubMed  Google Scholar 

  • Fitzjohn SM, Palmer MJ, May JE, Neeson A, Morris SA, Collingridge GL (2001) A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro. J Physiol 537(Pt 2):421–430

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F (2012) ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain. Neuron 76:1091–1107

    Article  CAS  PubMed  Google Scholar 

  • Fukata M, Kaibuchi K (2001) Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol 2:887–897

    Article  CAS  PubMed  Google Scholar 

  • Gallagher SM, Daly CA, Bear MF, Huber KM (2004) Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. J Neurosci 24:4859–4864

    Article  CAS  PubMed  Google Scholar 

  • Gilman SR, Iossifov I, Levy D, Ronemus M, Wigler M, Vitkup D (2011) Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70:898–907

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gladding CM, Collett VJ, Jia Z, Bashir ZI, Collingridge GL, Molnár E (2009) Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD. Mol Cell Neurosci 40:267–279

    Article  CAS  PubMed  Google Scholar 

  • Govek EE, Newey SE, Van Aelst L (2005) The role of the Rho GTPases in neuronal development. Genes Dev 19(1):1–49

    Article  CAS  PubMed  Google Scholar 

  • Gu J, Lee CW, Fan Y, Komlos D, Tang X, Sun C, Yu K, Hartzell HC, Chen G, Bamburg JR, Zheng JQ (2010) ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Nat Neurosci 13:1208–1215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurniak CB, Perlas E, Witke W (2005) The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol 278:231–241

    Article  CAS  PubMed  Google Scholar 

  • Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31–108

    Article  CAS  PubMed  Google Scholar 

  • Huang CC, Hsu KS (2006) Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region. J Neurochem 96:179–194

    Article  CAS  PubMed  Google Scholar 

  • Huang W, Zhou Z, Asrar S, Henkelman M, Xie W, Jia Z (2011) p21-activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic Properties. Mol Cell Biol 31:388–403

    Article  CAS  PubMed  Google Scholar 

  • Huber KM, Kayser MS, Bear MF (2000) Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288:1254–1257

    Article  CAS  PubMed  Google Scholar 

  • Huber KM, Roder JC, Bear MF (2001) Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. J Neurophysiol 86:321–325

    CAS  PubMed  Google Scholar 

  • Isaac JTR, Ashby MC, McBain CJ (2007) The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity. Neuron 54:859–871

    Article  CAS  PubMed  Google Scholar 

  • Jia ZP, Agopyan N, Miu P, Xiong Z, Henderson J, Gerlai R, Taverna F, Velumian A, MacDonald J, Carlen P, Abramow-Newerly W, Roder J (1996) Enhanced LTP in mice deficient in the AMPA receptor GluR2. Neuron 17:945–956

    Article  CAS  PubMed  Google Scholar 

  • Jia ZP, Todorovski Z, Meng YH, Asrar S, Wang LY (2009) LIMK-1 and actin regulation of spine and synaptic function. In: Squire LR (ed) New encyclopedia of neuroscience, vol 5. Academic Press, Oxford, pp 467–472

    Chapter  Google Scholar 

  • Kemp N, Bashir ZI (1999) Induction of LTD in the adult hippocampus by the synaptic activation of AMPA/kainate and metabotropic glutamate receptors. Neuropharmacology 38:495–504

    Article  CAS  PubMed  Google Scholar 

  • Lamprecht R, LeDoux J (2004) Structural plasticity and memory. Nat Rev Neurosci 5:45–54

    Article  CAS  PubMed  Google Scholar 

  • Lilien J, Balsamo J (2005) The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr Opin Cell Biol 17:459–465

    Article  CAS  PubMed  Google Scholar 

  • Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron 62:254–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Luo L (2002) Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu Rev Cell Dev Biol 18:601–635

    Article  CAS  PubMed  Google Scholar 

  • Lüscher C, Huber KM (2010) Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. Neuron 65:445–459

    Article  PubMed  PubMed Central  Google Scholar 

  • Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5–21

    Article  CAS  PubMed  Google Scholar 

  • Malinow R, Malenka RC (2003) AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25:103–126

    Article  Google Scholar 

  • Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang JQ (2005) The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci 25:2741–2752

    Article  CAS  PubMed  Google Scholar 

  • Matsuzaki M, Honkura N, Ellis-Davies GC, Kasai H (2004) Structural basis of long-term potentiation in single dendritic spines. Nature 429:761–766

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meng Y, Zhang Y, Tregoubov V, Janus C, Cruz L, Jackson M, Lu WY, MacDonald JF, Wang JY, Falls DL, Jia Z (2002) Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron 35:121–133

    Article  CAS  PubMed  Google Scholar 

  • Meng Y, Zhang Y, Jia Z (2003) Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3. Neuron 39:163–176

    Article  CAS  PubMed  Google Scholar 

  • Meng Y, Takahashi H, Meng J, Zhang Y, Lu G, Asrar S, Nakamura T, Jia Z (2004) Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase. Neuropharmacology 47:746–754

    Article  CAS  PubMed  Google Scholar 

  • Meng J, Meng Y, Hanna A, Janus C, Jia Z (2005) Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci 25:6641–6650

    Article  CAS  PubMed  Google Scholar 

  • Morishita W, Marie H, Malenka RC (2005) Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat Neurosci 8:1043–1050

    Article  CAS  PubMed  Google Scholar 

  • Moult PR, Gladding CM, Sanderson TM, Fitzjohn SM, Bashir ZI, Molnar E, Collingridge GL (2006) Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression. J Neurosci 26:2544–2554

    Article  CAS  PubMed  Google Scholar 

  • Nakamura Y, Wood CL, Patton AP, Jaafari N, Henley JM, Mellor JR, Hanley JG (2011) PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity. EMBO J 30:719–730

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (2002) Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell 108:233–246

    Article  CAS  PubMed  Google Scholar 

  • Okamoto K, Nagai T, Miyawaki A, Hayashi Y (2004) Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nat Neurosci 7:1104–1112

    Article  CAS  PubMed  Google Scholar 

  • Palmer MJ, Irving AJ, Seabrook GR, Jane DE, Collingridge GL (1997) The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36:1517–1532

    Article  CAS  PubMed  Google Scholar 

  • Passafaro M, Nakagawa T, Sala C, Sheng M (2003) Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2. Nature 424:677–681

    Article  CAS  PubMed  Google Scholar 

  • Pulido R, Zúñiga A, Ullrich A (1998) PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. EMBO J 17:7337–7350

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocca DL, Martin S, Jenkins EL, Hanley JG (2008) Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Nat Cell Biol 10:259–271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocca DL, Amici M, Antoniou A, Suarez EB, Halemani N, Murk K, McGarvey J, Jaafari N, Mellor JR, Collingridge GL, Hanley JG (2013) The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. Neuron 79:293–307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rust MB (2015) ADF/cofilin: a crucial regulator of synapse physiology and behavior. Cell Mol Life Sci 72(18):3521–3529

    Article  CAS  PubMed  Google Scholar 

  • Rust MB, Gurniak CB, Renner M, Vara H, Morando L, Görlich A, Sassoè-Pognetto M, Banchaabouchi MA, Giustetto M, Triller A, Choquet D, Witke W (2010) Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics. EMBO J 29:1889–1902

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saglietti L, Dequidt C, Kamieniarz K, Rousset MC, Valnegri P, Thoumine O, Beretta F, Fagni L, Choquet D, Sala C, Sheng M, Passafaro M (2007) Extracellular interactions between GluR2 and N-cadherin in spine regulation. Neuron 54:461–477

    Article  CAS  PubMed  Google Scholar 

  • Shepherd JD, Huganir RL (2007) The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu Rev Cell Dev Biol 23:613–643

    Article  CAS  PubMed  Google Scholar 

  • Tai CY, Kim SA, Schuman EM (2008) Cadherins and synaptic plasticity. Curr Opin Cell Biol 20:567–575

    Article  CAS  PubMed  Google Scholar 

  • Takeichi M (2007) The cadherin superfamily in neuronal connections and interactions. Nat Rev Neurosci 8:11–20

    Article  CAS  PubMed  Google Scholar 

  • Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M (2002) Cadherin regulates dendritic spine morphogenesis. Neuron 35:77–89

    Article  CAS  PubMed  Google Scholar 

  • Vanderklish PW, Edelman GM (2002) Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons. Proc Natl Acad Sci U S A 99:1639–1644

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Van Galen EJ, Ramakers GJ (2005) Rho proteins, mental retardation and the neurobiological basis of intelligence. Prog Brain Res 147:295–317

    Article  PubMed  Google Scholar 

  • Van Troys M, Huyck L, Leyman S, Dhaese S, Vandekerkhove J, Ampe C (2008) Ins and outs of ADF/cofilin activity and Regulation. Eur J Cell Biol 87:649–667

    Article  PubMed  Google Scholar 

  • Waung MW, Huber KM (2009) Protein translation in synaptic plasticity: mGluR-LTD, Fragile X. Curr Opin Neurobiol 19:319–326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Williams EJ, Williams G, Gour B, Blaschuk O, Doherty P (2000) INP, a novel N-cadherin antagonist targeted to the amino acids that flank the HAV motif. Mol Cell Neurosci 15:456–464

    Article  CAS  PubMed  Google Scholar 

  • Wolf M, Zimmermann AM, Görlich A, Gurniak CB, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB (2014) ADF/Cofilin controls synaptic actin dynamics and regulates synaptic vesicle mobilization and exocytosis. Cereb Cortex 25(9):2863–2875. [Epub ahead of print]

    Article  PubMed  Google Scholar 

  • Xiao MY, Zhou Q, Nicoll RA (2001) Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors. Neuropharmacology 41:664–671

    Article  CAS  PubMed  Google Scholar 

  • Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393:809–812

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Venkitaramani DV, Gladding CM, Kurup P, Molnar E, Collingridge GL, Lombroso PJ (2008) The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. J Neurosci 28:10561–10566

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou Q, Homma KJ, Poo MM (2004) Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 44:749–757

    Article  CAS  PubMed  Google Scholar 

  • Zhou Z, Meng Y, Asrar S, Todorovski Z, Jia Z (2009) A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56:81–89

    Article  CAS  PubMed  Google Scholar 

  • Zhou Z, Hu J, Passafaro M, Xie W, Jia Z (2011) GluA2 (GluR2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization. J Neurosci 31:819–833

    Article  CAS  PubMed  Google Scholar 

  • Zimmermann AM, Jene T, Wolf M, Görlich A, Gurniak CB, Sassoè-Pognetto M, Witke W, Friauf E, Rust MB (2014) Attention-deficit/hyperactivity disorder-like phenotype in a mouse model with impaired actin dynamics. Biol Psychiatry 78:95–106

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the Canadian Institutes of Health Research (CIHR, MOP119421, ZPJ), Canadian Natural Science and Engineering Research Council (NSERC, RGPIN341498, ZPJ), CIHR, and China Joint Health Research Initiative Program (81161120543, ZPJ) and the MRC (GLC).

Author information

Authors and Affiliations

  1. Neurosciences & Mental Health Program, The Hospital for Sick Children, Department of Physiology, University of Toronto, Toronto, Canada

    Zhengping Jia Ph.D.

  2. Centre for Synaptic Plasticity, School of Physiology & Pharmacology, University of Bristol, Bristol, UK

    Graham Collingridge Ph.D.

Authors
  1. Zhengping Jia Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Graham Collingridge Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhengping Jia Ph.D. .

Editor information

Editors and Affiliations

  1. Neuropharmacology Unit I.N.M. Neuromed, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Richard Teke Ngomba

  2. Department of Physiology and Biochemistry, University of Malta, Malta, Italy

    Giuseppe Di Giovanni

  3. Neuropharmacology Unit, I.N.M. Neuromed, Pozzilli, Isernia, Italy

    Giuseppe Battaglia

  4. Dipartimento di Fisiologia Umana, Università di Roma, Roma, Italy

    Ferdinando Nicoletti

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Jia, Z., Collingridge, G. (2017). Regulation of Hippocampal mGluR-Dependent Long-Term Depression by GluA2-Dependent Cofilin-Mediated Actin Remodeling. In: Ngomba, R., Di Giovanni, G., Battaglia, G., Nicoletti, F. (eds) mGLU Receptors. The Receptors, vol 31. Humana Press, Cham. https://doi.org/10.1007/978-3-319-56170-7_12

Download citation

Publish with us

Policies and ethics

Search

Navigation