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Radiotherapy in the Management of Testicular Cancers

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Abstract

Testicular cancers are the most common solid malignancies affecting males between the ages of 15 and 35 years, although it accounts for only about 1% of all cancers in men. Approximately 95% of testicular tumors are germ cell tumors (GCT). At diagnosis, 1–2% of cases are bilateral and 80% of patients are diagnosed at stage I. The risk factors for testicular cancers are family history, cryptorchidism, altered hormonal environment, low fertility, abnormal sperm analysis, and immunosuppression. For treatment purposes, two broad categories are recognized: pure seminoma (no non-seminomatous elements present) and all others, which together are termed non-seminomatous germ cell tumors (NSGCT). Seminoma is highly sensitive to chemotherapy and radiotherapy (RT). The prognosis of patients is generally good; cure is an expected outcome in the majority of cases, even with metastatic disease.

Keywords

  • Seminoma
  • Radiotherapy
  • Non-seminoma
  • Testicular tumors

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Yildirim, B.A., Onal, C. (2017). Radiotherapy in the Management of Testicular Cancers. In: Ozyigit, G., Selek, U. (eds) Principles and Practice of Urooncology. Springer, Cham. https://doi.org/10.1007/978-3-319-56114-1_7

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