Skip to main content
Book cover

Principles and Practice of Urooncology pp 319–331Cite as

Proton Therapy for the Treatment of Prostate Cancer

  • 1038 Accesses

Abstract

Treatment using proton beam has advantages over X-rays due to its physical characteristics, which allow for dose escalation of the tumor with less scatter radiation dose to the surrounding tissues. There have been multiple published reports showing excellent clinical outcomes after treatment with proton therapy for prostate cancer. However, there continues to be significant controversy regarding the clinical advantage of proton therapy over using X-rays with intensity-modulated radiation therapy (IMRT) as there have been no randomized trials comparing the two treatments reported. This chapter will summarize the physics of the proton therapy and the recent technical advances in the delivery of the proton beam, review the clinical results, and describe the treatment protocol used at our institution for the use of proton therapy in the treatment of prostate cancer patients.

Keywords

  • Proton therapy
  • Prostate cancer

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-319-56114-1_19
  • Chapter length: 13 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   139.00
Price excludes VAT (USA)
  • ISBN: 978-3-319-56114-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   179.99
Price excludes VAT (USA)
Hardcover Book
USD   179.99
Price excludes VAT (USA)
Learn about institutional subscriptions
Fig. 19.1
Fig. 19.2
Fig. 19.3
Fig. 19.4
Fig. 19.5
Fig. 19.6

References

  1. Wilson RR. Radiological use of fast protons. Radiology. 1946;45(7):487–91.

    CrossRef  Google Scholar 

  2. Particle Therapy Co-Operative Group (PTCOG) website.

    Google Scholar 

  3. Pollack A, Zagars GK, Starkschall G, et al. Prostate cancer radiation dose response: results of the M.D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys. 2002;53(5):1097–105.

    CrossRef  PubMed  Google Scholar 

  4. Kuban DA, Tucker SL, Dong L, et al. Long-term results of the M.D. Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70(1):67–74.

    CrossRef  PubMed  Google Scholar 

  5. Zietman AL, Bae K, Slater JD, et al. Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/American college of radiology 95–09″. JCO. 2010;28(7):1106–11.

    CrossRef  Google Scholar 

  6. Zhu XR, Sahoo N, Zhang X, et al. Intensity modulated proton therapy treatment planning using single-field optimization: the impact of monitor unit constraints on plan quality. Med Phys. 2010;37(3):1210–9.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  7. Pedroni E, Bacher R, Blattmann H, et al. The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization. Med Phys. 1995;22(1):37–53.

    CAS  CrossRef  PubMed  Google Scholar 

  8. Haberer T, Becher W, Schardt D, et al. Magnetic scanning system for heavy ion therapy. Nucl Instrum Methods Phys Res A. 1993;330:296–305.

    CrossRef  Google Scholar 

  9. Al-Mamgani A, van Putten WL, Heemsbergen WD, et al. Update of Dutch multicenter dose-escalation trial for radiotherapy for localized prostate cancer. Int J Radiat Biol Phys. 2008;72(4):980–8.

    CrossRef  Google Scholar 

  10. Talcott JA, Rossi C, Shipley WU, et al. Patient-reported long-term outcomes after conventional and high-dose combined proton and photon radiation for early prostate cancer. JAMA. 2010;303(11):1046–53.

    CAS  CrossRef  PubMed  Google Scholar 

  11. Slater JD, Rossi CJ, Yonemoto LT, et al. Proton therapy for prostate cancer: the initial Loma Linda University experience. Int J Radiat Oncol Biol Phys. 2004;59(2):348–52.

    CrossRef  PubMed  Google Scholar 

  12. Bryant C, Smith TL, Henderson RH, et al. Five-year biochemical results, toxicity, and patient-reported quality of life after delivery of dose-escalated image guided proton therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2016;95(1):422–34.

    CrossRef  PubMed  Google Scholar 

  13. Pugh TJ, Munsell MF, Choi S, et al. Quality of life and toxicity from passively scattered and spot-scanning proton beam therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2013;87(5):946–53.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  14. Hoppe BS, Michalski JM, Mendenhall NP, et al. Comparative effectiveness study of patient-reported outcomes after proton therapy or intensity-modulated radiotherapy for prostate cancer. Cancer. 2014;120(7):1076–82.

    CrossRef  PubMed  Google Scholar 

  15. Fang P, Mick R, Deville C, et al. A case-matched study of toxicity outcomes after proton therapy and intensity-modulated radiation therapy for prostate cancer. Cancer. 2015;121(7):1118–27.

    CrossRef  PubMed  Google Scholar 

  16. Yu JB, Soulos PR, Herrin J, et al. Proton versus intensity-modulated radiotherapy for prostate cancer: patterns of care and early toxicity. J Natl Cancer Inst. 2013;105(1):25–32.

    CAS  CrossRef  PubMed  Google Scholar 

  17. Hall EJ, Wuu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys. 2003;56(1):83–8.

    CrossRef  PubMed  Google Scholar 

  18. Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys. 2006;65(1):1–7.

    CrossRef  PubMed  Google Scholar 

  19. Fontenot JD, Lee AK, Newhauser WD. Int J Radiat Oncol Biol Phys. 2009;74(2):616–22.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  20. Cheung J, Kudchadker RJ, Zhu XR, et al. Dose perturbations and image artifacts caused by carbon-coated ceramic and stainless steel fiducials used in proton therapy for prostate cancer. Phys Med Biol. 2010;55(23):7135–47.

    CrossRef  PubMed  Google Scholar 

  21. Sejpal SV, Amos RA, Bluett JB, et al. Dosimetric changes resulting from patient rotational setup errors in proton therapy prostate plans. Int J Radiat Oncol Biol Phys. 2009;75(1):40–8.

    CrossRef  PubMed  Google Scholar 

  22. Meyer J, Bluett JB, Amos RA, et al. Spot scanning proton beam therapy for prostate cancer: treatment planning technique and analysis of consequences of rotational and translational alignment error. Int J Radiat Oncol Biol Phys. 2010;78(2):428–34.

    CrossRef  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Seungtaek Choi M.D.

Authors
  1. Seungtaek Choi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Seungtaek Choi M.D. .

Editor information

Editors and Affiliations

  1. Chair and Professor, Department of Radiation Oncology, Hacettepe University, Ankara, Turkey

    MD Gokhan Ozyigit

  2. Chair and Professor, Department of Radiation Oncology, Koc University, Istanbul, Turkey

    MD Ugur Selek

Rights and permissions

Reprints and Permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Choi, S. (2017). Proton Therapy for the Treatment of Prostate Cancer. In: Ozyigit, G., Selek, U. (eds) Principles and Practice of Urooncology. Springer, Cham. https://doi.org/10.1007/978-3-319-56114-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-56114-1_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56113-4

  • Online ISBN: 978-3-319-56114-1

  • eBook Packages: MedicineMedicine (R0)