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Adjuvant or Salvage Radiotherapy in Postoperative Prostate Cancer

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Abstract

Prostate-specific antigen (PSA) screening increased the diagnosis of prostate cancer at a localized stage to be treated with a curative intent; approximately half of them undergo radical prostatectomy, and roughly one third of surgically treated patients are expected to experience a recurrence in 10 years’ follow-up. Once PSA failure occurs, many develop distant metastases at a median of 8 years and afterward followed by cancer-related death at a median of 5 years. Biochemical failure risk after radical prostatectomy is mainly expected mostly in men with any of the following features: detectable postoperative PSA, positive surgical margins , extraprostatic extension of tumor (T3a), seminal vesicle invasion (T3b), and Gleason score ≥ 8. The radiotherapy in the undetectable PSA environment (<0.01 ng/mL) within 4 months after prostatectomy is termed as “adjuvant, ” while radiotherapy in rising PSA within any time after prostatectomy is defined as “salvage. ”

Keywords

  • Prostate cancer
  • Adjuvant radiotherapy
  • Salvage radiotherapy

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Correspondence to Deborah A. Kuban M.D., F.A.C.R., F.A.S.T.R.O. .

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Selek, U., Bolukbasi, Y., Kuban, D.A. (2017). Adjuvant or Salvage Radiotherapy in Postoperative Prostate Cancer. In: Ozyigit, G., Selek, U. (eds) Principles and Practice of Urooncology. Springer, Cham. https://doi.org/10.1007/978-3-319-56114-1_17

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  • DOI: https://doi.org/10.1007/978-3-319-56114-1_17

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