Abstract
Pulmonary hypertension is a common comorbidity in patients with chronic kidney disease and on renal replacement therapy. Given the heterogeneity of study methods, the true disease burden of pulmonary hypertension and its impact on kidney transplant outcomes is unclear. The pathogenesis of pulmonary hypertension in patients with chronic kidney disease and on maintenance dialysis is multifactorial. Patients with significant pulmonary hypertension being evaluated for kidney transplantation will benefit from a multidisciplinary approach in the pre-transplant evaluation and risk stratification to optimize their outcomes.
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References
Hoeper MM, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25): Suppl D 42–50.
Simmonneau G, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25): Suppl D 34–41.
Yigla M, et al. Pulmonary hypertension in patients with end-stage renal disease. Chest. 2003;123(5):1577–82.
Amin M, et al. Pulmonary hypertension in patients with chronic renal failure: role of PTH and pulmonary artery calcifications. Chest. 2003;124:2093–7.
Nakhoul F, et al. The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access. Nephrol Dial Transplant. 2005;20:1686–92.
Tarrass F, et al. Doppler echocardiograph evaluation of pulmonary hypertension in patients undergoing hemodialysis. Hemodial Int. 2006;10:356–9.
Havlucu Y, et al. Pulmonary hypertension in patients with chronic renal failure. Respiration. 2007;74:503–10.
Acarturk G, et al. The relationship between arteriovenous fistula blood flow rate and pulmonary artery pressure in hemodialysis patients. Int Urol Nephrol. 2008;40:509–13.
Bozbas SS, et al. Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation. Transpl Proc. 2009;41:2753–6.
Abdelwhab S, et al. Pulmonary hypertension in CRF patients. Am J Nephrol. 2008;28:990–7.
Dagli CE, et al. Prevalance and factors affecting pulmonary hypertension in hemodialysis patients. Respiration. 2009;78:411–5.
Fabbian F, et al. Pulmonary hypertension in dialysis patients: a cross-sectional italian study. Int J Nephrol. 2011;2011:283475.
Ramasubbu K, et al. A prospective echocardiographic evaluation of pulmonary hypertension in chronic hemodialysis patients in the United States: prevalance and clinical signficance. Int J Gen Med. 2010;3:279–86.
Etemadi J, et al. Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients. Rev Port Pneumol. 2011;18:10–4.
Agarwal R, et al. Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients. Nephrol Dial Transplant. 2012;27:3908–14.
Mukhtar KN, et al. Frequency of pulmonary hypertension in hemodialysis patients. Pak J Med Sci. 2014;30(6):1319–22.
Alhamad EH, et al. Pulmonary hypertension in end-stage renal disease and post renal transplant patients. J Thorac Dis. 2014;6(6):606–14.
Kumbar L, et al. Pulmonary hypertension in peritoneal dialysis patients. Adv Perit Dial. 2007;23:127–31.
Unal A, et al. Pulmonary hypertension in peritoneal dialysis patients: prevalence and risk factors. Perit Dial Int. 2009;29:191–8.
Berger M, et al. Quantitative assessment of pulmonary hypertension in patients with tricuspid regurgitation using continuous wave Doppler ultrasound. J Am Coll Cardiol. 1985;6:359–65.
Pabst S, et al. Pulmonary hypertension in patients with chronic kidney disease on dialysis and without dialysis: results of the PEPPER-study. PLoS ONE. 2012;7:e35310.
Yigla M, et al. Arterio-venous access in end-stage renal disease patients and pulmonary hypertension. Ther Adv Respir Dis. 2008;2:49–53.
Yigla M, et al. Pulmonary hypertension is an independent predictor of mortality in hemodialysis patients. Kidney Int. 2009;75:969–75.
Issa N, et al. Pulmonary hypertension is associated with reduced patient survival after kidney transplantation. Transplantation. 2008;86:1384–88.
Zlotnick DM, et al. Non-invasive detection of pulmonary hypertension prior to renal transplantation is a predictor of incrweased risk for early graft dysfunction. Nephrol Dial Transplant. 2010;25:3090–6.
Casas-Aparicio G, et al. The effect of successful kidney transplantation on ventricular dysfunction and pulmonary hypertension. Transplant Proc. 2010;42:3524–8.
Reddy YN, et al. Progressive pulmonary hypertension: another criterion for expeditious renal transplantation. Saudi J Kidney Dis Transpl. 2013;24:925–9.
Clarkson MR, et al. Reversal of pulmonary hypertension after ligation of a brachiocephalic arteriovenous fistula. Am J Kidney Dis. 2002;40(e8):1–4.
Unal A, et al. The long-term effect of arteriovenous fistula creation in the development of pulmonary hypertension in hemodialysis patients. Hemodial Int. 2010;14:398–402.
Raza F, et al. Case series of 5 patients with end stage renal disease with reversible dyspnea, heart failure and pulmonary hypertension related to arteriovenous dialysis access. Pulm Circ. 2015;5(2):398–406.
Vaziri ND. Effect of chronic renal failure on nitric oxide metabolism. Am J Kidney Dis. 2001;38:S74–9.
Dschietzig T, et al. Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Crt Biochem Biophys Res Commun. 2001;289:245–61.
Conger JD, et al. Pulmonary calcification in chronic dialysis patients. Ann Intern Med. 1975;83:330–6.
Faubert PF, et al. Pulmonary artery calcification in hemodialyzed patients detected by technetium-99m diphosphate scanning. Kidney Int. 1980;18:95–102.
Yigla M, et al. Pulmonary calcification in hemodialysis patients: correlation with pulmonary artery pressure values. Kidney Int. 2004;66:806–10.
Genctoy G, et al. Secondary hyperparathyroidism is associated with pulmonary hypertension in older patients with chronic kidney disease and proteinuria. Int Urol Nephrol. 2015;47:353–8.
Harp RJ, et al. Pulmonary hypertension among end-stage renal failure patients following hemodialysis access thrombectomy. Cardiovasc Intervent Radiol. 2005;28:17–22.
Hsieh MY, et al. Pulmonary hypertension in hemodialysis patients following repeated endovascular thrombectomy. Acta Cardiol Sin. 2016;32:299–306.
Barak M, et al. Pathophysiology and clinical implications of microbubbles during hemodialysis. Semin Dial. 2008;21:232–8.
Perkett EA, et al. Continuous air embolization into sheep causes sustained pulmonary hypertension and increased pulmonary vasoreactivity. Am J Pathol. 1988;132:444–54.
Fujita M, et al. Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2001;280:L39–49.
Humbert M, et al. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med. 1995;151:1628–31.
Lentine, et al. Cardiac disease evaluation and management among kidney and liver transplantation candidates. Circulation. 2012;126:617–63.
McLaughlin VV, et al. Management of pulmonary artery hypertension. J Am Coll Cardiol. 2015;65:1976–97.
Rich S, et al. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med. 1992;327:76–81.
Olsen KM, et al. Anticoagulation and survival in pulmonary arterial hypertension—results from the comparative, prospective registry of newly initiated therapies for pulmonary hypertension (COMPERA). Circulation. 2014;129:57–65.
Satoh K, et al. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 2006;113:1442–50.
Hasegawa J, et al. Altered pulmonary vascular reactivity in mice with excessive erythrocytosis. Am J Resp Crit Care Med. 2004;169:829–35.
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Banerji, S., Vaidya, A. (2017). Pulmonary Hypertension in the Potential Kidney Transplant Recipient. In: Rangaswami, J., Lerma, E., Ronco, C. (eds) Cardio-Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-319-56042-7_23
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DOI: https://doi.org/10.1007/978-3-319-56042-7_23
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