Skip to main content

Ultraviolet A-1 in Dermatological Diseases

  • Chapter
  • First Online:
Ultraviolet Light in Human Health, Diseases and Environment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 996))

Abstract

The exposure to ultraviolet radiations and visible light, or phototherapy, is a well-known therapeutic tool available for the treatment of many dermatological disorders. The continuos medical and technological progresses, of the last 50 years, have involved the field of phototherapy, which evolved from UVA and PUVA in its various forms, to the development of narrowband UVB (NB-UVB) and NB-UVB micro-focused phototherapies. Further advances in technology have now permitted the introduction of a new device emitting UVA-1 radiations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gianfaldoni S, Zarrab Z, Lotti T (2014) Phototherapy and Vitiligo re-pigmentation: from PUVA to Micro-focused Phototherapy. J Pigm Disord 1:102

    Google Scholar 

  2. Lapolla W et al (2011) A review of phototherapy protocols for psoriasis treatment. J Am Acad Dermatol 64:936–949

    Article  PubMed  Google Scholar 

  3. Singh S, Khandpur S, Sharma VK, Ramam M (2013) Comparison of efficacy and side effect profile of oral PUVA vs. oral PUVA sol in the treatment of vitiligo: a 36 week prospective study. J Eur Acad Dermatol Venereol 27(11):1344–1351

    Article  CAS  PubMed  Google Scholar 

  4. Gianfaldoni S, Lotti ZM (2014) Vitiligo repigmentation: what’s new? J Dermatol Clin Res 2(3):1023

    Google Scholar 

  5. Lotti TM, Hercogova J, D’Erme AM et al (2013) UVA-1in dermatology: clinical studies and observations. In UVA1 in dermatology. Evidence, data, hypotheses. Nuova Prhomos Publishing House, Città di Castello, pp 74–160

    Google Scholar 

  6. de Gruijl FR (2002) Photocarcinogenesis: UVA vs. UVB radiation. Skin Pharmacol Appl Ski Physiol 15(5):316–320

    Article  Google Scholar 

  7. Tewari A, Grage MM, Harrison GI et al (2013) UVA1 is skin deep: molecular and clinical implications. Photochem Photobiol Sci 12(1):95–103

    Article  CAS  PubMed  Google Scholar 

  8. Duthie MS, Kimber I, Dearman RJ et al (2000) Differential effects of UVA1 and UVB radiation on Langerhans cell migration in mice. J Photochem Photobiol B 57(2–3):123–131

    Article  CAS  PubMed  Google Scholar 

  9. Skov L, Hansen H, Allen M et al (1998) Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor-alpha in human skin. Br J Dermatol 138(2):216–220

    Article  CAS  PubMed  Google Scholar 

  10. Grundmann JU, Böckelmann R, Bonnekoh B et al (2001) UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin. Photochem Photobiol 74(4):587–592

    Article  CAS  PubMed  Google Scholar 

  11. Godar DE, Lucas AD (2005) Ultraviolet-A1 (340–400 nm)-mediated receptor and cytokine changes of transformed lymphocytes. Photodermatol Photoimmunol Photomed 21(1):23–31

    Article  CAS  PubMed  Google Scholar 

  12. Breuckmann F, von Kobyletzki G, Avermaete A et al (2003) Mechanisms of apoptosis: UVA1-induced immediate and UVB-induced delayed apoptosis in human T cells in vitro. J Eur Acad Dermatol Venereol 17(4):418–429

    Article  CAS  PubMed  Google Scholar 

  13. Krutmann J, Grewe M (1995) Involvement of cytokines, DNA damage, and reactive oxygen intermediates in ultraviolet radiation-induced modulation of intercellular adhesion molecule-1 expression. Source J Invest Dermatol 105(1 Suppl):67S–70S

    Article  CAS  Google Scholar 

  14. Mikita N, Kanazawa N, Yoshimasu T et al (2009) The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice. Clin Dev Immunol 2009:673952. doi:10.1155/2009/673952. Epub 2009 Apr 26

    Article  PubMed  PubMed Central  Google Scholar 

  15. Vielhaber G, Grether-Beck S, Koch O et al (2006) Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts. Photochem Photobiol Sci 5(3):275–282. Epub 2006 Feb 7

    Article  CAS  PubMed  Google Scholar 

  16. Gambichler T, Skrygan M, Tomi NS et al (2007) Significant downregulation of transforming growth factor-beta signal transducers in human skin following ultraviolet-A1 irradiation. Br J Dermatol 156(5):951–956. Epub 2007 Mar 23

    Article  CAS  PubMed  Google Scholar 

  17. Kreuter A, Hyun J, Skrygan M et al (2006) Ultraviolet A1 phototherapy decreases inhibitory SMAD7 gene expression in localized scleroderma. Arch Dermatol Res 298(6):265–272. Epub 2006 Sep 19

    Article  CAS  PubMed  Google Scholar 

  18. Ring J, Alomar A, Bieber T et al (2012) Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol 26(8):1045–1060

    Article  CAS  PubMed  Google Scholar 

  19. Letić M (2009) Exposure to sunlight as adjuvant therapy for dyshidrotic eczema. Med Hypotheses 73(2):203–204

    Article  PubMed  Google Scholar 

  20. Zerbinati N et al (2012) A preliminary study to assess the efficacy of a new UVA1 laser for treatment of psoriasis. Photomed Laser Surg 30(10):610–614

    Article  PubMed  Google Scholar 

  21. Beattie PE, Dawe RS, Ferguson J et al (2006) UVA1 phototherapy for genital lichen sclerosus. Clin Exp Dermatol 31(3):343–347

    Article  CAS  PubMed  Google Scholar 

  22. Su O, Onsun N, Onay HK et al (2011) Effectiveness of medium-dose ultraviolet A1 phototherapy in localized scleroderma. Int J Dermatol 50(8):1006–1013

    Article  PubMed  Google Scholar 

  23. Gambichler T, Terras S, Kreuter A (2013) Treatment regimens, protocols, dosage, and indications for UVA1 phototherapy: facts and controversies. Clin Dermatol 31(4):438–454

    Article  PubMed  Google Scholar 

  24. Simon JC, Pfieger D, Schöpf E (2000) Recent advances in phototherapy. Eur J Dermatol 10(8):642–645

    CAS  PubMed  Google Scholar 

  25. Zandi S, Kalia S, Lui H (2012) UVA1 phototherapy: a concise and practical review. Skin Ther Lett 17(1):1–4

    Google Scholar 

  26. Oberholzer PA, Cozzio A, Dummer R et al (2009) Granulomatous slack skin responds to UVA1 phototherapy. Dermatology 219(3):268–271

    Article  PubMed  Google Scholar 

  27. Lotti TM, Hercogova J, D’Erme AM et al (2013) UVA-1in dermatology: clinical studies and observations. In UVA1 in dermatology. Evidence, data, hypotheses. Nuova Prhomos Publishing House, Città di Castello, pp 160–171

    Google Scholar 

  28. Lotti TM, Hercogova J, D’Erme AM et al (2013) UVA -1 Light vs UVA −1 Laser emission Devices. In UVA1 in dermatology. Evidence, data, hypotheses. Nuova Prhomos Publishing House, Città di Castello, pp 68–71

    Google Scholar 

  29. Patrizi A, Raone B, Ravaioli GM (2015) Management of atopic dermatitis: safety and efficacy of phototherapy. Clin Cosmet Investig Dermatol 8:511–520

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Torello M. Lotti .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lotti, T.M., Gianfaldoni, S. (2017). Ultraviolet A-1 in Dermatological Diseases. In: Ahmad, S. (eds) Ultraviolet Light in Human Health, Diseases and Environment. Advances in Experimental Medicine and Biology, vol 996. Springer, Cham. https://doi.org/10.1007/978-3-319-56017-5_9

Download citation

Publish with us

Policies and ethics