Abstract
Ultraviolet light has long been used to alleviate a number of skin conditions, and its efficacy is well known. However, over-exposure to ultraviolet radiation has a number of detrimental effects and thus it is vital to maintain a dose to skin within the therapeutic window. To maximise treatment gain whilst circumventing potential side-effects of over-exposure requires accurate determination of irradiance and skin-dose. This is complicated by the fact that ultraviolet radiation is essentially absorbed at the skin surface, which means that changing orientation of the patient and source can modulate dose received. In addition, irregular patient shapes mean dose must be carefully calibrated. This chapter focuses on methods of determination of dose, clinical protocols for quantifying radiation dose received and mathematical models for estimating these quantities.
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Grimes DR (2015) Ultraviolet radiation therapy and UVR dose models. Med Phys 42(1):440
Ellinger F (1958) Medical radiation biology. Cancer 11(4):872–872
Diffey BL (1980) Ultraviolet radiation physics and the skin. Phys Med Biol 25(3):405
Commission de l’Eclairage (1970) International lighting vocabulary
Diffey B, Hart G (1997) Ultraviolet and blue-light phototherapy: principles, sources, dosimetry and safety. Institute of Physics and Engineering in Medicine, York
Moseley H, Association HP et al (1988) Non-ionising radiation: microwaves, ultraviolet and laser radiation. Adam Hilger Bristol, Philadelphia
Diffey BL (2002) What is light? Photodermatol Photoimmunol Photomed 18(2):68–74
Murdoch JB (1985) Illumination engineering: from Edison’s lamp to the laser. Macmillan, New York
Grundmann-Kollmann M, Behrens S, Podda M, Peter RU, Kaufmann R, Kerscher M (1999) Phototherapy for atopic eczema with narrow-band UVB. J Am Acad Dermatol 40(6):995–997
Reynolds NJ, Franklin V, Gray JC, Diffey BL, Farr PM (2001) Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atopic eczema: a randomised controlled trial. Lancet 357(9273):2012–2016
Bhatnagar A, Kanwar A, Parsad D, De D (2007) Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: an open prospective study. J Eur Acad Dermatol Venereol 21(5):638–642
Honigsmann H (2008) Polymorphous light eruption. Photodermatol Photoimmunol Photomed 24(3):155–161
Ohe S, Danno K, Sasaki H, Isei T, Okamoto H, Horio T (2004) Treatment of acquired perforating dermatosis with narrowband ultraviolet B. J Am Acad Dermatol 50(6):892–894
Pavlotsky F, Nathansohn N, Kriger G, Shpiro D, Trau H (2008) Ultraviolet-B treatment for cutaneous lichen planus: our experience with 50 patients. Photodermatol Photoimmunol Photomed 24(2):83–86
Wackernagel A, Legat FJ, Hofer A, Quehenberger F, Kerl H, Wolf P (2007) Psoralen plus UVA vs. UVB-311 nm for the treatment of lichen planus. Photodermatol Photoimmunol Photomed 23(1):15–19
Diederen PV, van Weelden H, Sanders CJ, Toonstra J, van Vloten WA (2003) Narrowband UVB and psoralen-UVA in the treatment of early-stage mycosis fungoides: a retrospective study. J Am Acad Dermatol 48(2):215–219
Parrish JA, Jaenicke KF, Anderson RR (1982) Erythema and melanogenesis action spectra of normal human skin. Photochem Photobiol 36(2):187–191
Ribeiro DT, Madzak C, Sarasin A, Mascio PD, Sies H, Menck CFM (1992) Singlet oxygen induced DNA damage and mutagenicity in a singlestranded SV40-based shuttle vector. Photochem Photobiol 55(1):39–45
TB F. The validity and practicality of sun-reactive skin types i through vi. Arch Dermatol 1988; 124(6):869–871
Sliney DH (1997) Ultraviolet radiation effects upon the eye: problems of dosimetry. Radiat Prot Dosim 72(3–4):197–206
Fisher GJ, Wang Z, Datta SC, Varani J, Kang S, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337(20):1419–1429
de Gruijl FR (1999) Skin cancer and solar {UV} radiation. Eur J Cancer 35(14):2003–2009
Fitzpatrick TB (1975) Soleil et peau. J Med Esthet 2(7):33–34
Grimes DR (2010) Development of a computational dose model for use in ultraviolet phototherapy, PhD thesis
Taylor D, Anstey A, Coleman A, Diffey B, Farr P, Ferguson J et al (2002) Guidelines for dosimetry and calibration in ultraviolet radiation therapy: a report of a British Photodermatology Group workshop. Br J Dermatol 146(5):755–763
Pye SD, Martin CJ (2000) A study of the directional response of ultraviolet radiometers: I. Practical evaluation and implications for ultraviolet measurement standards. Phys Med Biol 45(9):2701
Coleman AJ, Collins M, Saunders JE (2000) Traceable calibration of ultraviolet meters used with broadband, extended sources. Phys Med Biol 45(1):185
Martin C, Pye S (2000) A study of the directional response of ultraviolet radiometers: II. Implications for ultraviolet phototherapy derived from computer simulations. Phys Med Biol 45(9):2713
Moseley H (2005) Ultraviolet A dosimetry in photopatch test centres in Europe. J Eur Acad Dermatol Venereol 19(2):187–190
Moseley H (2001) Scottish UV dosimetry guidelines, ScUViDo. Photodermatol Photoimmunol Photomed 17(5):230–233
Amatiello H, Martin CJ (2006) Ultraviolet phototherapy: review of options for cabin dosimetry and operation. Phys Med Biol 51(2):299
Grimes DR, Martin CJ, Phanco G (2012) Investigations of cabin design in UV phototherapy. Med Phys 39(6):3019–3025
Currie G, Evans A, Smith D, Martin C, McCalman S, Bilsland D (2001) An automated dosimetry system for testing whole-body ultraviolet phototherapy cabinets. Phys Med Biol 46(2):333
Grimes DR, Robbins C, OHare NJ (2010) Dose modeling in ultraviolet phototherapy. Med Phys 37(10):5251–5257
Jackson C, Thomas R (1979) The specular reflectivity of bright anodized aluminium. Trans Inst Met Finish 57(3):105–109
Grimes DR, Robbins C, Martin CJ, Phanco G, OHare NJ (2011) Reflection modeling in ultraviolet phototherapy. Med Phys 38(7):4312–4320
Grimes DR (2012) A computational simulation of reflector and tube effects in ultraviolet phototherapy. Phys Med Biol 57(20):6661
Grimes DR (2016) Simulation of parabolic reflectors for ultraviolet phototherapy. Phys Med Biol 61(16):N394
Duarte I, Rotter A, Malvestiti A, Silva M (2009) The role of glass as a barrier against the transmission of ultraviolet radiation: an experimental study. Photodermatol Photoimmunol Photomed 25(4):181–184
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Grimes, D.R. (2017). Dose Quantification in UV Phototherapy. In: Ahmad, S. (eds) Ultraviolet Light in Human Health, Diseases and Environment. Advances in Experimental Medicine and Biology, vol 996. Springer, Cham. https://doi.org/10.1007/978-3-319-56017-5_29
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DOI: https://doi.org/10.1007/978-3-319-56017-5_29
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