Abstract
As ultraviolet (UV) radiation is naturally and ubiquitously emitted by the sun, almost everyone is exposed to it on a daily basis, and it is necessary for normal physiological function. Human exposure to solar UV radiation thus has important health implications. The generation of reactive oxygen species (ROS) by UV radiation is one of the mechanisms through which UV light can manifest its possible detrimental effects on health. When an imbalance develops due to ROS generation exceeding the body’s antioxidant defence mechanisms, oxidative stress can develop. Oxidative stress can lead to cellular damage (e.g. lipid peroxidation and DNA fragmentation), apoptosis and cell death. Broadly UV can induce ROS by affecting the cellular components directly or by means of photosensitization mechanisms. More specifically UV light can induce ROS by affecting the enzyme catalase and up-regulating nitric oxide synthase (NOS) synthesis. It may also cause a decrease in protein kinase C (PKC) expression leading to increased ROS production. UVR is capable of modifying DNA and other chromophores resulting in elevated ROS levels. The effects of raised ROS levels can vary based on the intracellular oxidant status of the cell. It is therefore important to protect yourself against the potentially harmful effects of UV light as it can lead to pathological UV-induced ROS production.
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References
Ainbinder D, Touitou E (2010) Skin photodamage prevention: state of the art and new prospects. In: Textbook of aging skin. Springer, Berlin
Aitken GR, Henderson JR, Chang SC, Mcneil CJ, Birch-Machin MA (2007) Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes. Clin Exp Dermatol 32:722–727
Belkin M, Césarini J, Diffey B, Hietanen M, Kojima M, Mariutti G, Mckinlay A, Repacholi M, Roy C, Rubenstein R (1994) Protection against exposure to ultraviolet radiation. World Health Organization/United Nations Environment Programme, Geneva
Berger, U., Wilson P, Mcclelland RA, Colston K, Haussler MR, Pike JW, Coombes RC (1988) Immunocytochemical detection of 1,25-dihydroxyvitamin D receptors in normal human tissues. J Clin Endocrinol Metab 67(3):607–613
Berridge MJ (1988) Vitamin D, reactive oxygen species and calcium signalling in ageing and disease. LID - 10.1098/rstb.2015.0434 [doi] LID - 20150434 [pii]
Bhattacharyya S, Saha J (2015) Tumour, oxidative stress and host T cell response: cementing the dominance. Scand J Immunol 82(6):477–488
Bickers DR, Athar M (2006) Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 126:2565–2575
Bossi O, Gartsbein M, Leitges M, Kuroki T, Grossman S, Tennenbaum T (2008) UV irradiation increases ROS production via PKCδ signaling in primary murine fibroblasts. J Cell Biochem 105:194–207
Chen TC, Lu Z, Holick MF (2010) Photobiology of vitamin D. Vitamin D. Springer, Berlin
Deliconstantinos G, Villiotou V, Stavrides JC (1996) Alterations of nitric oxide synthase and xanthine oxidase activities of human keratinocytes by ultraviolet B radiation: potential role for peroxynitrite in skin inflammation. Biochem Pharmacol 51:1727–1738
Denat L, Kadekaro AL, Marrot L, Leachman SA, Abdel-Malek ZA (2014) Melanocytes as instigators and victims of oxidative stress. J Investig Dermatol 134:1512–1518
D’orazio J, Jarrett S, Amaro-Ortiz A, Scott T (2013) UV radiation and the skin. Int J Mol Sci 14:12222–12248
Halliwell B (1991) Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 91:S14–S22
Heck DE, Vetrano AM, Mariano TM, Laskin JD (2003) UVB light stimulates production of reactive oxygen species unexpected role for catalase. J Biol Chem 278:22432–22436
Hussein A, Elhassaneen Y (2014) Natural dye from red onion skins and applied in dyeing cotton fabrics for the production of women’s headwear resistance to ultraviolet radiation (UVR). J Am Sci 10(3):129–139
Kim AL, Labasi JM, Zhu Y, Tang X, Mcclure K, Gabel CA (2005) Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J Invest Dermatol 124:1318–1325
Kimeswenger S, Schwarz A, Födinger D, Müller S, Pehamberger H, Schwarz T, Jantschitsch C (2016) Infrared A radiation promotes survival of human melanocytes carrying ultraviolet radiation-induced DNA damage. Exp Dermatol 25:447–452
Liu S, Mizu H, Yamauchi H (2010) Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression, and regulation of multiple signaling pathways. Free Radic Biol Med 48:772–780
Lucas R, Mcmichael T, Smith W, Armstrong B (2006) Solar ultraviolet radiation. Assessing the environmental burden of disease at national and local levels, Environmental burden of disease series, vol 13. World Health Organization, Geneva
Pattison DI, Davies MJ (2006) Actions of ultraviolet light on cellular structures. EXS 96:131–157
Picardo M, Grammatico P, Roccella F, Roccella M, Grandinetti M, Del Porto G, Passi S (1996) Imbalance in the antioxidant pool in melanoma cells and normal melanocytes from patients with melanoma. J Investig Dermatol 107:322–326
Poljšak B, Dahmane R (2012) Free radicals and extrinsic skin aging. Dermatol Res Prac, pp. 1–4
Raha S, Robinson BH (2000) Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci 25:502–508
Reelfs O, Tyrrell RM, Pourzand C (2004) Ultravioleta radiation-induced immediate iron release is a key modulator of the activation of NF-kappaB in human skin fibroblasts. J Invest Dermatol 122:1440–1447
Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K (2015). Oxidative stress in aging human skin. Biomol Ther 5:545–589
Sorg O, Antille C, Saurat J-H (2004) Retinoids, other topical vitamins, and antioxidants. Basic Clin Dermatol 28:89–116
Wei H, Cai Q, Rahn R, Zhang X (1997) Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-hydroxy-deoxyguanosine in DNA. Free Radic Biol Med 23:148–154
World Health Organization (2002) Global Solar UV Index: A Practical Guide. WHO, Geneva
Zhang X, Rosenstein BS, Wang Y, Lebwohl M, Wei H (1997) Identification of possible reactive oxygen species involved in ultraviolet radiation-induced oxidative DNA damage. Free Radic Biol Med 23:980–985
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de Jager, T.L., Cockrell, A.E., Du Plessis, S.S. (2017). Ultraviolet Light Induced Generation of Reactive Oxygen Species. In: Ahmad, S. (eds) Ultraviolet Light in Human Health, Diseases and Environment. Advances in Experimental Medicine and Biology, vol 996. Springer, Cham. https://doi.org/10.1007/978-3-319-56017-5_2
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DOI: https://doi.org/10.1007/978-3-319-56017-5_2
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