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Significance of EGFR Expression in Circulating Tumor Cells

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Isolation and Molecular Characterization of Circulating Tumor Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 994))

Abstract

This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis , and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.

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Authors and Affiliations

  1. GENYO. Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada Av. Ilustration, 114, 18016, Granada, Spain

    María José Serrano, María Jesús Alvarez-Cubero, Diego De Miguel Pérez, Alba Rodríguez-Martínez, Lucas Gonzalez-Herrera, Inmaculada Robles-Fernandez, Jose Luis García Puche & José Antonio Lorente

  2. Integral Oncology Division, Clinical University Hospital, Av. Dr. Olóriz 16, 18012, Granada, Spain

    María José Serrano & José Exposito Hernandez

  3. Faculty of Medicine, Department of Forensic Medicine, University of Granada, Av. de la Investigación, 18071, Granada, Spain

    Diego De Miguel Pérez, Alba Rodríguez-Martínez, Lucas Gonzalez-Herrera & José Antonio Lorente

Authors
  1. María José Serrano
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  2. María Jesús Alvarez-Cubero
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  3. Diego De Miguel Pérez
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  4. Alba Rodríguez-Martínez
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  5. Lucas Gonzalez-Herrera
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  6. Inmaculada Robles-Fernandez
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  7. José Exposito Hernandez
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  8. Jose Luis García Puche
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  9. José Antonio Lorente
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Corresponding author

Correspondence to María José Serrano .

Editor information

Editors and Affiliations

  1. University of California San Francisco, San Francisco, California, USA

    Mark Jesus M. Magbanua

  2. University of California San Francisco, San Francisco, California, USA

    John W. Park

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Serrano, M.J. et al. (2017). Significance of EGFR Expression in Circulating Tumor Cells. In: Magbanua, M., Park, J. (eds) Isolation and Molecular Characterization of Circulating Tumor Cells. Advances in Experimental Medicine and Biology, vol 994. Springer, Cham. https://doi.org/10.1007/978-3-319-55947-6_16

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