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Rationale for a Combination of Selected Micronutrients to Improve Cognition and Prevent or Slow Down Age-Related Cognitive Impairment

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Sustainable Nutrition in a Changing World

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Abstract

This chapter deals with the question as to whether micronutrients contribute to the maintenance of cognitive function during the aging process. The onset of mild cognitive impairment (MCI) and at least the development of dementia are insidious, and occur years before the loss of cognition becomes apparent. Besides a couple of factors, including genetics and lifestyle, nutrition is claimed as an important factor which interacts with basic pathologies of cognitive decline. In particular, micronutrients (vitamins, trace elements and minerals) can mitigate the risk of cognitive decline, especially in elderly people at risk of deficiencies. Based on epidemiological findings and existing scientific evidence, two major groups of micronutrients will be discussed: homocysteine-lowering vitamins and antioxidants. Cognitive decline, with its early clinical diagnosis mild cognitive impairment (MCI), becomes evident in the age group >60 years. The quality of diet determines survival and health status in free-living elderly people within a European population. High plasma levels of ß-carotene (as a marker for vegetable intake) and α-tocopherol (as a marker for edible plant oils) are especially associated with lower mortality in the elderly (Buijsse et al. 2005). Epidemiological studies demonstrate that with increasing age, the prevalence of nutritional deficiencies increases, in particular deficiencies of antioxidants (ß-carotene, vitamins C, E and selenium and zinc) and B-vitamins (folic acid, B6, B12). Deficiencies of micronutrients however, may contribute to, or even promote, cognitive impairment. Consequently it is suggested that a straightforward strategy to improve micronutrient status may improve cognition or delay the onset of MCI and Alzheimer dementia (AD).

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References

  1. ter Borg S., Verlaan S., Hemsworth J et al Micronutrient intakes and potential inadequacies of community dwelling older adults: a systematic review. BJN 2015; 113:1195–1206

    Google Scholar 

  2. Galan P, Viteri FE, Bertrais S, Czernichow S, Faure H, Arnaud J, Ruffieux D, Chenal S, Arnault N, Favier A, Roussel AM, Hercberg S. Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr. 2005 ;59(10):1181–90.

    Google Scholar 

  3. Faure H, Preziosi P, Roussel AM, Bertrais S, Galan P, Hercberg S, Favier A. Factors influencing blood concentration of retinol, alpha-tocopherol, vitamin C, and beta-carotene in the French participants of the SU.VI.MAX trial. Eur J Clin Nutr. 2006 Jun;60(6):706–17. Epub 2006 Jan 4

    Google Scholar 

  4. Johnson KA, Bernard MA, Funderburg K. Vitamin nutrition in older adults. Clin Geriatr Med. 2002 ;18(4):773–99. Review.

    Google Scholar 

  5. de Lau LM, Refsum H, Smith AD, Johnston C, Breteler MM. Plasma folate concentration and cognitive performance: Rotterdam Scan Study. Am J Clin Nutr. 2007 Sep;86(3):728–34

    Google Scholar 

  6. Akbaraly T, Hininger-Favier I, Carrière I, Arnaud J, Gouriet V, Roussel AM, Berr C. Plasma selenium over time and cognitive decline in the elderly. Epidemiology 2007; 18: 52–58

    Google Scholar 

  7. Hu P, Bretsky P, Crimmins EM, Gurainik JM, Reuben DB, Seeman´TE. Association between serum beta-carotene levels and decline of cognitive function in highfunctioning older persons with or without apolipoprotein E4 alleles: MacArthur Studies of Successful Aging. J Gerontol Med Sci 2006; 61A, 6: 616–620

    Google Scholar 

  8. Maxwell CJ, Hicks MS, Hogan DE, Basran J, Ebly EM. Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement Geriatr Cogn Disord 2005; 20: 45–51

    Google Scholar 

  9. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT et al. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am J Clin Nutr 2005; 81: 508–514

    Google Scholar 

  10. Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT et al. Reduced risk of Alzheimer’s disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 2004; 61: 82–88

    Google Scholar 

  11. Laurin D, Masaki KH, Foley DJ, White LR, Launer IJ. Midlife dietary intake of antioxidants and risk of late-life incident dementia: The Honolulu-Asia Aging Study. Am J Epidemiol 2004; 159: 959–967

    Google Scholar 

  12. Luchsinger JA, Tang MX, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer’s disease. Arch Neurol 2003; 60: 203–208

    Google Scholar 

  13. Gray SL, Hanlon JT, Landerman LR, Artz M, Schmader KE, Fillenbaum GG. Is antioxidant use prospective of cognitive function in the community-dwelling elderly? Am J Geriatr Pharmacother 2003; 1: 3–10

    Google Scholar 

  14. Grodstein F, Chen J, Willet WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr 2003; 77: 975–984

    Google Scholar 

  15. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N et al. Dietary intake of antioxidant nutrients and the risk of incidence Alzheimer’s disease in a biracial community study. JAMA 2002; 287: 3230–3237

    Google Scholar 

  16. Kang JH, Cook N, Manson J, Buring JE, Grodstein F. A randomised trial of vitamin E supplementation and cognitive function in women. Arch Int Med 2006; 166: 2462–2468

    Google Scholar 

  17. Petersen RC, Thomas RG, Grundmen M, Bennett D, Doody R, Ferris S et al. Vitamin E and donepezil for for the treatment of mild cognitive impairment. N Engl J Med 2005; 352: 2379–2388

    Google Scholar 

  18. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study. N Engl J Med 1997; 336: 1216–1222

    Google Scholar 

  19. Wengreen H, Munger R, Zandi P et al. Prospective study of fruit, vegetable and fish in dementia and cognitive function in the Cache County Study on memory, health and aging. J Nutr Health Aging 2006; 10: 209 (Abstract)

    Google Scholar 

  20. Raffaitin C, Letenneur L, Dartigue JF, Alperovitch A, Barberger-Gateau P. Consommation d’aliments riches en antioxydants ou en acides gras et risque de démence chez les sujets de la cohorte des 3 Cité. 6èrnes Journées Francophone de Nutrition, Nice, France, 29 nov – 1er déc 2006. Nutrition et Métabolisme 2006; 20 suppl 2 : 894 (Abtract)

    Google Scholar 

  21. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 2006; 67: 1370–1376

    Google Scholar 

  22. Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB. Fruit and vegetable juices and Alzheimer’s disease: the Kame project. Am J Med 2006; 119: 751–759

    Google Scholar 

  23. Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol 2006; 59: 912–921

    Google Scholar 

  24. Morris MC, Evans DA, Schneider JA, Tangney CC, Bienias JL, Aggarwal NT. Dietary folate and vitamins B12 and B6 not associated with incident Alzheimer’s disease. J Alzheimers Dis 2006; 9: 435–443

    Google Scholar 

  25. Kado D, Karlamangla AS, Huang MH et al. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005; 118: 161–167

    Google Scholar 

  26. Morris MC, Evans DA, Bienias JL et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005; 62: 641–645

    Google Scholar 

  27. Corrada MM, Kawas CH, Hallfrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer’s disease with high folate intake: the Baltimore Longitudinal Study of Aging. Alzheimers Dement 2005; 11–18

    Google Scholar 

  28. Mooijaar SP, Gussekloo J, Frolich M et al. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leider 85-Plus study. Am J Nutr 2005; 82: 866–871

    Google Scholar 

  29. Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A III. High homocyteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005; 82: 627–635

    Google Scholar 

  30. Ravaglia G, Forti P, Maioli F et al. Homocysteine and folate as risk factors fpr dementia and Alzheimer’s disease. Am J Clin Nutr 2005; 82: 636–643

    Google Scholar 

  31. Luchsinger JA, Tang MX, Shea S, Miller J, Grren R, Mayeux R. Plasma homocysteine levels and risk of Alzheimer’s disease. Neurology 2004; 62: 1972–1976

    Google Scholar 

  32. Teunissen CE, Blom AH, van Boxtel MPJ et al. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging 2003; 7: 155–159

    Google Scholar 

  33. Seshardi S, Beiser A, Selhub J, Jacques PF et al. Plasma homocysteine as a risk factor dementia and Alzheimer’s disease. N Engl J Med 2003; 346: 476–483

    Google Scholar 

  34. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B (12) and folate in relation to the development of Alzheimer’s disease. Neurology 2001; 56: 1188–1194

    Google Scholar 

  35. Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of higher folate intake to lower risk of Alzheimer’s disease in the elderly. Arch Neuro, 2007; 64: 86–92

    Google Scholar 

  36. McMahon JA, Green TJ, Skeaff CM, Knight RC, Mann JI, Williams SM. A controlled trial of homocyteine lowering and cognitive performance. N Engl J Med 2006; 354: 2764–2772

    Google Scholar 

  37. Clarke R, Harrison G, Richards S, Vital Trial Collaborative Group. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med 2003; 254: 67–75

    Google Scholar 

  38. Bryan J, Calvaresi E, Hughes D. Short-term folate, vitamin B-12 or vitamin B-6 supplemetation slightly affects memory performance but not mood in women of various ages. J Nutr 2002; 132: 1345–1356

    Google Scholar 

  39. Fioravanti M, Ferrario E, Massaia M, Cappa G, Rivolta G, Grossi E et al. Low folate levels in the cognitive decline of elderly patients and efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr 1997; 26: 1–13

    Google Scholar 

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Authors and Affiliations

  1. Nutrition medicine, Department of Biological Chemistry and Nutrition, Food Security Center, University of Hohenheim, Garbenstraβe 30, 70593, Stuttgart, Germany

    Hans Konrad Biesalski

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  1. Hans Konrad Biesalski
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Correspondence to Hans Konrad Biesalski .

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Editors and Affiliations

  1. Universität Hohenheim, Stuttgart, Baden-Württemberg, Germany

    Hans Konrad Biesalski

  2. Nutritional Sciences, University of Washington, Seattle, Washington, USA

    Adam Drewnowski

  3. Tufts Medical School, Boston, Massachusetts, USA

    Johanna T. Dwyer

  4. Northern Irerland Centre for Food a, University of Ulster Northern Irerland Centre for Food a, Coleraine, United Kingdom

    JJ Strain

  5. DSM Nutritional Products Europe Ltd. , Kaiseraugst, Switzerland

    Peter Weber

  6. DSM Nutritional Products Europe Ltd. , Kaiseraugst, Switzerland

    Manfred Eggersdorfer

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Biesalski, H.K. (2017). Rationale for a Combination of Selected Micronutrients to Improve Cognition and Prevent or Slow Down Age-Related Cognitive Impairment. In: Biesalski, H., Drewnowski, A., Dwyer, J., Strain, J., Weber, P., Eggersdorfer, M. (eds) Sustainable Nutrition in a Changing World. Springer, Cham. https://doi.org/10.1007/978-3-319-55942-1_6

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