Skip to main content
  • 430 Accesses

Abstract

Though there are many potential comorbidities with OB and OV, youth with ASD or ND have specific medical considerations that impact their health and their weight status. Frequency of sleep disturbances and disorders is high in this population. Assessing and treating sleep issues have benefits that extend to multiple areas of a youth’s life including behavioral and emotional functioning and increasing health behaviors. ASD and ND youth also have the potential of being prescribed medications that can cause weight gain. Healthcare providers need to carefully analyze the best option for symptom reduction without negative health impacts. Though there is some promising data to support the use of metformin to offset the weight gain and metabolic changes of psychotropic medications (particularly SGAs), there is not adequate evidence to support this currently.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Allik, H., Larsson, J.-O., & Smedje, H. (2006). Insomnia in school-age children with Asperger syndrome or high-functioning autism. BMC Psychiatry, 6, 18. doi:10.1186/1471-244X-6-18

  • Aman, M. G., Bukstein, O. G., Gadow, K. D., Arnold, L. E., Molina, B. S. G., McNamara, N. K., …, Findling, R. L. (2014). What does risperidone add to parent training and stimulant for severe aggression in child attention-deficit/hyperactivity disorder? Journal of the American Academy of Child and Adolescent Psychiatry, 53(1), 47–60.e1. doi:10.1016/j.jaac.2013.09.022

  • Andersen, I. M., Kaczmarska, J., McGrew, S. G., & Malow, B. A. (2008). Melatonin for insomnia in children with autism spectrum disorders. Journal of Child Neurology, 23(5), 482–485. doi:10.1177/0883073807309783

  • Angriman, M., Caravale, B., Novelli, L., Ferri, R., & Bruni, O. (2015). Sleep in children with neurodevelopmental disabilities. Neuropediatrics, 46(3), 199–210. doi:10.1055/s-0035-1550151

  • Appleton, R. E., Jones, A. P., Gamble, C., Williamson, P. R., Wiggs, L., Montgomery, P., …, Gringras, P. (2012). The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: A randomised, double-blind, placebo-controlled, parallel study (MENDS). Health Technology Assessment (Winchester, England), 16(40), i–239. doi:10.3310/hta16400

  • Arman, S., Sadramely, M. R., Nadi, M., & Koleini, N. (2008). A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. Saudi Medical Journal, 29(8), 1130–1134.

    PubMed  Google Scholar 

  • Arora, T., & Taheri, S. (2015). Associations among late chronotype, body mass index and dietary behaviors in young adolescents. International Journal of Obesity (2005), 39(1), 39–44. doi:10.1038/ijo.2014.157

  • Austeng, M. E., Øverland, B., Kværner, K. J., Andersson, E.-M., Axelsson, S., Abdelnoor, M., et al. (2014). Obstructive sleep apnea in younger school children with down syndrome. International Journal of Pediatric Otorhinolaryngology, 78(7), 1026–1029. doi:10.1016/j.ijporl.2014.03.030

  • Barlow, S. E. (2007). Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: Summary report. Pediatrics, 120(Suppl 4), S164–S192. doi:10.1542/peds.2007-2329C

  • Beck, M. H., Cataldo, M., Slifer, K. J., Pulbrook, V., & Guhman, J. K. (2005). Teaching children with attention deficit hyperactivity disorder (ADHD) and autistic disorder (AD) how to swallow pills. Clinical Pediatrics, 44(6), 515–526.

    Article  PubMed  Google Scholar 

  • Becker, S. P., Froehlich, T. E., & Epstein, J. N. (2016). Effects of methylphenidate on sleep functioning in children with attention-deficit/hyperactivity disorder. Journal of Developmental and Behavioral Pediatrics: JDBP, 37(5), 395–404. doi:10.1097/DBP.0000000000000285

  • Beherec, L., Lambrey, S., Quilici, G., Rosier, A., Falissard, B., & Guillin, O. (2011). Retrospective review of clozapine in the treatment of patients with autism spectrum disorder and severe disruptive behaviors. Journal of Clinical Psychopharmacology, 31(3), 341–344. doi:10.1097/JCP.0b013e318218f4a1

  • Bendz, L. M., & Scates, A. C. (2010). Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. The Annals of Pharmacotherapy, 44(1), 185–191. doi:10.1345/aph.1M365

  • Braam, W., Didden, R., Smits, M. G., & Curfs, L. M. G. (2008). Melatonin for chronic insomnia in Angelman syndrome: A randomized placebo-controlled trial. Journal of Child Neurology, 23(6), 649–654. doi:10.1177/0883073808314153

  • Broder-Fingert, S., Brazauskas, K., Lindgren, K., Iannuzzi, D., & Van Cleave, J. (2014). Prevalence of overweight and obesity in a large clinical sample of children with autism. Academic Pediatrics, 14(4), 408–414. doi:10.1016/j.acap.2014.04.004

  • Bruni, O., Verrillo, E., Novelli, L., & Ferri, R. (2010). Prader-Willi syndrome: Sorting out the relationships between obesity, hypersomnia, and sleep apnea. Current Opinion in Pulmonary Medicine, 16(6), 568–573. doi:10.1097/MCP.0b013e32833ef547

  • Butler, J. V., Whittington, J. E., Holland, A. J., Boer, H., Clarke, D., & Webb, T. (2002). Prevalence of, and risk factors for, physical ill-health in people with Prader-Willi syndrome: A population-based study. Developmental Medicine and Child Neurology, 44(4), 248–255.

    Article  PubMed  Google Scholar 

  • Calarge, C. A., Acion, L., Kuperman, S., Tansey, M., & Schlechte, J. A. (2009). Weight gain and metabolic abnormalities during extended risperidone treatment in children and adolescents. Journal of Child and Adolescent Psychopharmacology, 19(2), 101–109. doi:10.1089/cap.2008.007

  • Calarge, C. A., Nicol, G., Schlechte, J. A., & Burns, T. L. (2014). Cardiometabolic outcomes in children and adolescents following discontinuation of long-term risperidone treatment. Journal of Child and Adolescent Psychopharmacology, 24(3), 120–129. doi:10.1089/cap.2013.0126

  • Caldwell, B. A., & Redeker, N. S. (2015). Maternal stress and psychological status and sleep in minority preschool children. Public Health Nursing (Boston, Mass.), 32(2), 101–111. doi:10.1111/phn.12104

  • Chaput, J.-P., Leduc, G., Boyer, C., Bélanger, P., LeBlanc, A. G., Borghese, M. M., et al. (2014). Electronic screens in children’s bedrooms and adiposity, physical activity and sleep: Do the number and type of electronic devices matter? Canadian Journal of Public Health = Revue Canadienne De Santé Publique, 105(4), e273–e279.

    PubMed  Google Scholar 

  • Churchill, S. S., Kieckhefer, G. M., Bjornson, K. F., & Herting, J. R. (2015). Relationship between sleep disturbance and functional outcomes in daily life habits of children with down syndrome. Sleep, 38(1), 61–71. doi:10.5665/sleep.4326

  • Cohen, D., Bonnot, O., Bodeau, N., Consoli, A., & Laurent, C. (2012). Adverse effects of second-generation antipsychotics in children and adolescents: A Bayesian meta-analysis. Journal of Clinical Psychopharmacology, 32(3), 309–316. doi:10.1097/JCP.0b013e3182549259

  • Cohen, S., Conduit, R., Lockley, S. W., Rajaratnam, S. M., & Cornish, K. M. (2014). The relationship between sleep and behavior in autism spectrum disorder (ASD): A review. Journal of Neurodevelopmental Disorders, 6(1), 44. doi:10.1186/1866-1955-6-44

  • Correll, C. U. (2008). Assessing and maximizing the safety and tolerability of antipsychotics used in the treatment of children and adolescents. The Journal of Clinical Psychiatry, 69(Suppl 4), 26–36.

    PubMed  Google Scholar 

  • Correll, C. U., Manu, P., Olshanskiy, V., Napolitano, B., Kane, J. M., & Malhotra, A. K. (2009). Cardiometabolic risk of second-generation antipsychotics during first-time use in children and adolescents. JAMA : The Journal of the American Medical Association, 302(16), 1765–1773. doi:10.1001/jama.2009.1549

  • Coury, D. L., Anagnostou, E., Manning-Courtney, P., Reynolds, A., Cole, L., McCoy, R., …, Perrin, J. M. (2012). Use of psychotropic medication in children and adolescents with autism spectrum disorders. Pediatrics, 130(Suppl 2), S69–S76. doi:10.1542/peds.2012-0900D

  • Creasey, N., & Finlay, F. (2013). Question 2: Do weighted blankets improve sleep in children with an autistic spectrum disorder? Archives of Disease in Childhood, 98(11), 919–920. doi:10.1136/archdischild-2013-305011

  • Curtin, C., Anderson, S. E., Must, A., & Bandini, L. (2010). The prevalence of obesity in children with autism: A secondary data analysis using nationally representative data from the National Survey of Children’s Health. BMC Pediatrics, 10, 11. doi:10.1186/1471-2431-10-11

  • Danilovich, N., Mastrandrea, L. D., Cataldi, L., & Quattrin, T. (2014). Methylphenidate decreases fat and carbohydrate intake in obese teenagers. Obesity (Silver Spring, Md.), 22(3), 781–785. doi:10.1002/oby.20574

  • de Jong, E., Stocks, T., Visscher, T. L. S., HiraSing, R. A., Seidell, J. C., & Renders, C. M. (2012). Association between sleep duration and overweight: The importance of parenting. International Journal of Obesity (2005), 36(10), 1278–1284. doi:10.1038/ijo.2012.119

  • de Vinck-Baroody, O., Shui, A., Macklin, E. A., Hyman, S. L., Leventhal, J. M., & Weitzman, C. (2015). Overweight and obesity in a sample of children with autism spectrum disorder. Academic Pediatrics. doi:10.1016/j.acap.2015.03.008

  • DiFeo, N., Meltzer, L. J., Beck, S. E., Karamessinis, L. R., Cornaglia, M. A., Traylor, J., …, Marcus, C. L. (2012). Predictors of positive airway pressure therapy adherence in children: A prospective study. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 8(3), 279–286. doi:10.5664/jcsm.1914

  • Dittmann, R. W., Cardo, E., Nagy, P., Anderson, C. S., Bloomfield, R., Caballero, B., …, Coghill, D. (2013). Efficacy and safety of lisdexamfetamine dimesylate and atomoxetine in the treatment of attention-deficit/hyperactivity disorder: A head-to-head, randomized, double-blind, phase IIIb study. CNS Drugs, 27(12), 1081–1092. doi:10.1007/s40263-013-0104-8

  • Domecq, J. P., Prutsky, G., Leppin, A., Sonbol, M. B., Altayar, O., Undavalli, C., …, Murad, M. H. (2015). Clinical review: Drugs commonly associated with weight change: A systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 100(2), 363–370. doi:10.1210/jc.2014-3421

  • Egan, A. M., Dreyer, M. L., Odar, C. C., Beckwith, M., & Garrison, C. B. (2013). Obesity in young children with autism spectrum disorders: Prevalence and associated factors. Childhood Obesity (Print), 9(2), 125–131. doi:10.1089/chi.2012.0028

  • Elliott, J. P., Cherpes, G., Kamal, K., Chopra, I., Harrison, C., Riedy, M., …, Kalarchian, M. (2015). Relationship between antipsychotics and weight in patients with Prader-Willi syndrome. Pharmacotherapy, 35(3), 260–268. doi:10.1002/phar.1558

  • Engelhardt, C. R., Mazurek, M. O., & Sohl, K. (2013). Media use and sleep among boys with autism spectrum disorder, ADHD, or typical development. Pediatrics, 132(6), 1081–1089. doi:10.1542/peds.2013-2066

  • Fadini, C. C., Lamônica, D. A., Fett-Conte, A. C., Osório, E., Zuculo, G. M., Giacheti, C. M., et al. (2015). Influence of sleep disorders on the behavior of individuals with autism spectrum disorder. Frontiers in Human Neuroscience, 9, 347. doi:10.3389/fnhum.2015.00347

  • Fleischhaker, C., Heiser, P., Hennighausen, K., Herpertz-Dahlmann, B., Holtkamp, K., Mehler-Wex, C., …, Warnke, A. (2008). Weight gain in children and adolescents during 45 weeks treatment with clozapine, olanzapine and risperidone. Journal of Neural Transmission (Vienna, Austria: 1996), 115(11), 1599–1608. doi:10.1007/s00702-008-0105-9

  • Foley, L. S., Maddison, R., Jiang, Y., Marsh, S., Olds, T., & Ridley, K. (2013). Presleep activities and time of sleep onset in children. Pediatrics, 131(2), 276–282. doi:10.1542/peds.2012-1651

  • Francazio, S. K., Fahrenkamp, A. J., D’Auria, A. L., Sato, A. F., & Flessner, C. A. (2015). Parent psychopathology as a mediator of the relationship between anxiety and sleep problems in children. Families, Systems, & Health, 33(2), 146–154. doi:10.1037/fsh0000119

  • Garaulet, M., Ortega, F. B., Ruiz, J. R., Rey-López, J. P., Béghin, L., Manios, Y., …, Moreno, L. A. (2011). Short sleep duration is associated with increased obesity markers in European adolescents: Effect of physical activity and dietary habits. The HELENA study. International Journal of Obesity (2005), 35(10), 1308–1317. doi:10.1038/ijo.2011.149

  • Garg, J., Arun, P., & Chavan, B. S. (2014). Comparative short term efficacy and tolerability of methylphenidate and atomoxetine in attention deficit hyperactivity disorder. Indian Pediatrics, 51(7), 550–554.

    Article  PubMed  Google Scholar 

  • Garstang, J., & Wallis, M. (2006). Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child: Care, Health and Development, 32(5), 585–589. doi:10.1111/j.1365-2214.2006.00616.x

  • Goldman, S. E., Richdale, A. L., Clemons, T., & Malow, B. A. (2012). Parental sleep concerns in autism spectrum disorders: Variations from childhood to adolescence. Journal of Autism and Developmental Disorders, 42(4), 531–538. doi:10.1007/s10803-011-1270-5

  • Gringras, P., Green, D., Wright, B., Rush, C., Sparrowhawk, M., Pratt, K., …, Wiggs, L. (2014). Weighted blankets and sleep in autistic children—A randomized controlled trial. Pediatrics, 134(2), 298–306. doi:10.1542/peds.2013-4285

  • Gurbuz, F., Gurbuz, B. B., Celik, G. G., Yildirim, V., Ucakturk, S. A., Seydaoglu, G., …, Yuksel, B. (2016). Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder. Journal of Pediatric Endocrinology & Metabolism: JPEM, 29(1), 85–92. doi:10.1515/jpem-2015-0171

  • Heussler, H., Chan, P., Price, A. M. H., Waters, K., Davey, M. J., & Hiscock, H. (2013). Pharmacological and non-pharmacological management of sleep disturbance in children: An Australian Paediatric Research Network survey. Sleep Medicine, 14(2), 189–194. doi:10.1016/j.sleep.2012.09.023

  • Hirata, I., Mohri, I., Kato-Nishimura, K., Tachibana, M., Kuwada, A., Kagitani-Shimono, K., …, Taniike, M. (2015). Sleep problems are more frequent and associated with problematic behaviors in preschoolers with autism spectrum disorder. Research in Developmental Disabilities, 49–50, 86–99. doi:10.1016/j.ridd.2015.11.002

  • Ho, A. Y., & Dimitropoulos, A. (2010). Clinical management of behavioral characteristics of Prader-Willi syndrome. Neuropsychiatric Disease and Treatment, 6, 107–118.

    PubMed  PubMed Central  Google Scholar 

  • Hollway, J. A., Aman, M. G., & Butter, E. (2013). Correlates and risk markers for sleep disturbance in participants of the Autism Treatment Network. Journal of Autism and Developmental Disorders, 43(12), 2830–2843. doi:10.1007/s10803-013-1830-y

  • Ievers-Landis, C. E., Storfer-Isser, A., Rosen, C., Johnson, N. L., & Redline, S. (2008). Relationship of sleep parameters, child psychological functioning, and parenting stress to obesity status among preadolescent children. Journal of Developmental and Behavioral Pediatrics: JDBP, 29(4), 243–252. doi:10.1097/DBP.0b013e31816d923d

  • Ivan, D. L., & Cromwell, P. (2014). Clinical practice guidelines for management of children with down syndrome: Part II. Journal of Pediatric Health Care: Official Publication of National Association of Pediatric Nurse Associates & Practitioners, 28(3), 280–284. doi:10.1016/j.pedhc.2013.05.003

  • Jambhekar, S. K., Com, G., Tang, X., Pruss, K. K., Jackson, R., Bower, C., …, Ward, W. (2013). Role of a respiratory therapist in improving adherence to positive airway pressure treatment in a pediatric sleep apnea clinic. Respiratory Care, 58(12), 2038–2044. doi:10.4187/respcare.02312

  • Jerrell, J. M. (2010). Neuroendocrine-related adverse events associated with antidepressant treatment in children and adolescents. CNS Neuroscience & Therapeutics, 16(2), 83–90. doi:10.1111/j.1755-5949.2009.00106.x

  • Jeste, S. S. (2011). The neurology of autism spectrum disorders. Current Opinion in Neurology, 24(2), 132–139. doi:10.1097/WCO.0b013e3283446450

  • Ji, N. Y., & Findling, R. L. (2016). Pharmacotherapy for mental health problems in people with intellectual disability. Current Opinion in Psychiatry, 29(2), 103–125. doi:10.1097/YCO.0000000000000233

  • Johnson, C. R., Turner, K. S., Foldes, E., Brooks, M. M., Kronk, R., & Wiggs, L. (2013). Behavioral parent training to address sleep disturbances in young children with autism spectrum disorder: A pilot trial. Sleep Medicine, 14(10), 995–1004. doi:10.1016/j.sleep.2013.05.013

  • Kawabe, K., Horiuchi, F., Oka, Y., & Ueno, S.-I. (2014). The melatonin receptor agonist ramelteon effectively treats insomnia and behavioral symptoms in autistic disorder. Case Reports in Psychiatry, 2014, 561071. doi:10.1155/2014/561071

  • Kim, H.-W., Kim, S.-O., Shon, S., Lee, J.-S., Lee, H.-J., & Choi, J.-H. (2014). Effect of methylphenidate on height and weight in Korean children and adolescents with attention-deficit/hyperactivity disorder: A retrospective chart review. Journal of Child and Adolescent Psychopharmacology, 24(8), 448–453. doi:10.1089/cap.2014.0025

  • Klein, D. J., Cottingham, E. M., Sorter, M., Barton, B. A., & Morrison, J. A. (2006). A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. The American Journal of Psychiatry, 163(12), 2072–2079. doi:10.1176/ajp.2006.163.12.2072

  • Kohlstadt, I., & Wharton, G. (2013). Clinician uptake of obesity-related drug information: A qualitative assessment using continuing medical education activities. Nutrition Journal, 12, 44. doi:10.1186/1475-2891-12-44

  • Kotagal, S., & Broomall, E. (2012). Sleep in children with autism spectrum disorder. Pediatric Neurology, 47(4), 242–251. doi:10.1016/j.pediatrneurol.2012.05.007

  • Krakowiak, P., Goodlin-Jones, B., Hertz-Picciotto, I., Croen, L. A., & Hansen, R. L. (2008). Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: A population-based study. Journal of Sleep Research, 17(2), 197–206. doi:10.1111/j.1365-2869.2008.00650.x

  • Krill, R. A., & Kumra, S. (2014). Metabolic consequences of second-generation antipsychotics in youth: Appropriate monitoring and clinical management. Adolescent Health, Medicine and Therapeutics, 5, 171–182. doi:10.2147/AHMT.S49807

  • Landhuis, C. E., Poulton, R., Welch, D., & Hancox, R. J. (2008). Childhood sleep time and long-term risk for obesity: A 32-year prospective birth cohort study. Pediatrics, 122(5), 955–960. doi:10.1542/peds.2007-3521

  • Lee, H. H., Park, H. A., Kang, J. H., Cho, Y. G., Park, J. K., Lee, R., …, Kim, O. H. (2012). Factors related to body mass index and body mass index change in Korean children: Preliminary results from the obesity and metabolic disorders cohort in childhood. Korean Journal of Family Medicine, 33(3), 134–143. doi:10.4082/kjfm.2012.33.3.134

  • Liu, X., Forbes, E. E., Ryan, N. D., Rofey, D., Hannon, T. S., & Dahl, R. E. (2008). Rapid eye movement sleep in relation to overweight in children and adolescents. Archives of General Psychiatry, 65(8), 924–932. doi:10.1001/archpsyc.65.8.924

  • Lumeng, J. C., Somashekar, D., Appugliese, D., Kaciroti, N., Corwyn, R. F., & Bradley, R. H. (2007). Shorter sleep duration is associated with increased risk for being overweight at ages 9 to 12 years. Pediatrics, 120(5), 1020–1029. doi:10.1542/peds.2006-3295

  • Martinez, S. M., Tschann, J. M., Greenspan, L. C., Deardorff, J., Penilla, C., Flores, E., …, Butte, N. F. (2014). Is it time for bed? Short sleep duration increases risk of obesity in Mexican American children. Sleep Medicine, 15(12), 1484–1489. doi:10.1016/j.sleep.2014.09.009

  • Martinez-Raga, J., Knecht, C., & de Alvaro, R. (2015). Profile of guanfacine extended release and its potential in the treatment of attention-deficit hyperactivity disorder. Neuropsychiatric Disease and Treatment, 11, 1359–1370. doi:10.2147/NDT.S65735

  • Maski, K. P., Jeste, S. S., & Spence, S. J. (2011). Common neurological co-morbidities in autism spectrum disorders. Current Opinion in Pediatrics, 23(6), 609–615. doi:10.1097/MOP.0b013e32834c9282

  • May, T., Cornish, K., Conduit, R., Rajaratnam, S. M. W., & Rinehart, N. J. (2015). Sleep in high-functioning children with autism: Longitudinal developmental change and associations with behavior problems. Behavioral Sleep Medicine, 13(1), 2–18. doi:10.1080/15402002.2013.829064

  • McIntyre, R. S., & Jerrell, J. M. (2008). Metabolic and cardiovascular adverse events associated with antipsychotic treatment in children and adolescents. Archives of Pediatrics & Adolescent Medicine, 162(10), 929–935. doi:10.1001/archpedi.162.10.929

  • Miller, J. L., Linville, T. D., & Dykens, E. M. (2014). Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: A pilot study. Journal of Pediatric Endocrinology & Metabolism: JPEM, 27(1–2), 23–29. doi:10.1515/jpem-2013-0116

  • Millikovsky-Ayalon, M., Atzaba-Poria, N., & Meiri, G. (2015). The role of the father in child sleep disturbance: Child, parent, and parent-child relationship. Infant Mental Health Journal, 36(1), 114–127. doi:10.1002/imhj.21491

  • Montgomery, P., & Wiggs, L. (2015). Definitions of sleeplessness in children with attention-deficit hyperactivity disorder (ADHD): Implications for mothers’ mental state, daytime sleepiness and sleep-related cognitions. Child: Care, Health and Development, 41(1), 139–146. doi:10.1111/cch.12165

  • Nadeau, J. M., Arnold, E. B., Keene, A. C., Collier, A. B., Lewin, A. B., Murphy, T. K., et al. (2015). Frequency and clinical correlates of sleep-related problems among anxious youth with autism spectrum disorders. Child Psychiatry and Human Development, 46(4), 558–566. doi:10.1007/s10578-014-0496-9

  • Papadopoulos, N., Sciberras, E., Hiscock, H., Mulraney, M., McGillivray, J., & Rinehart, N. (2015). The efficacy of a brief behavioral sleep intervention in school-aged children with ADHD and comorbid autism spectrum disorder. Journal of Attention Disorders. doi:10.1177/1087054714568565

  • Phillips, K. L., Schieve, L. A., Visser, S., Boulet, S., Sharma, A. J., Kogan, M. D., …, Yeargin-Allsopp, M. (2014). Prevalence and impact of unhealthy weight in a national sample of US adolescents with autism and other learning and behavioral disabilities. Maternal and Child Health Journal, 18(8), 1964–1975. doi:10.1007/s10995-014-1442-y

  • Prashad, P. S., Marcus, C. L., Maggs, J., Stettler, N., Cornaglia, M. A., Costa, P., …, Barg, F. K. (2013). Investigating reasons for CPAP adherence in adolescents: A qualitative approach. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 9(12), 1303–1313. doi:10.5664/jcsm.3276

  • Pringsheim, T., Lam, D., Ching, H., & Patten, S. (2011a). Metabolic and neurological complications of second-generation antipsychotic use in children: A systematic review and meta-analysis of randomized controlled trials. Drug Safety, 34(8), 651–668. doi:10.2165/11592020-000000000-00000

  • Pringsheim, T., Panagiotopoulos, C., Davidson, J., Ho, J., & Canadian Alliance for Monitoring Effectiveness and Safety of Antipsychotics in Children (CAMESA) guideline group. (2011b). Evidence-based recommendations for monitoring safety of second-generation antipsychotics in children and youth. Paediatrics & Child Health, 16(9), 581–589.

    Google Scholar 

  • Reekie, J., Hosking, S. P. M., Prakash, C., Kao, K.-T., Juonala, M., & Sabin, M. A. (2015). The effect of antidepressants and antipsychotics on weight gain in children and adolescents. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 16(7), 566–580. doi:10.1111/obr.12284

  • Rimmer, J. H., Yamaki, K., Lowry, B. M. D., Wang, E., & Vogel, L. C. (2010). Obesity and obesity-related secondary conditions in adolescents with intellectual/developmental disabilities. Journal of Intellectual Disability Research: JIDR, 54(9), 787–794. doi:10.1111/j.1365-2788.2010.01305.x

  • Rojo, L. E., Gaspar, P. A., Silva, H., Risco, L., Arena, P., Cubillos-Robles, K., et al. (2015). Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacological Research, 101, 74–85. doi:10.1016/j.phrs.2015.07.022

  • Saenz, J., Yaugher, A., & Alexander, G. M. (2015). Sleep in infancy predicts gender specific social-emotional problems in toddlers. Frontiers in Pediatrics, 3, 42. doi:10.3389/fped.2015.00042

  • Safavi, P., Dehkordi, A. H., & Ghasemi, N. (2016). Comparison of the effects of methylphenidate and the combination of methylphenidate and risperidone in preschool children with attention-deficit hyperactivity disorder. Journal of Advanced Pharmaceutical Technology & Research, 7(4), 144–148. doi:10.4103/2231-4040.191425

  • Sahin, S., Yuce, M., Alacam, H., Karabekiroglu, K., Say, G. N., & Salıs, O. (2014). Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor in children and adolescents with attention deficit and hyperactivity disorder. International Journal of Psychiatry in Clinical Practice, 18(4), 280–287. doi:10.3109/13651501.2014.940054

  • Schneider, C., Corrigall, R., Hayes, D., Kyriakopoulos, M., & Frangou, S. (2014a). Systematic review of the efficacy and tolerability of clozapine in the treatment of youth with early onset schizophrenia. European Psychiatry: The Journal of the Association of European Psychiatrists, 29(1), 1–10. doi:10.1016/j.eurpsy.2013.08.001

  • Schneider, C., Taylor, D., Zalsman, G., Frangou, S., & Kyriakopoulos, M. (2014b). Antipsychotics use in children and adolescents: An on-going challenge in clinical practice. Journal of Psychopharmacology (Oxford, England), 28(7), 615–623. doi:10.1177/0269881114533599

  • Sedky, K., Bennett, D. S., & Pumariega, A. (2014). Prader Willi syndrome and obstructive sleep apnea: Co-occurrence in the pediatric population. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 10(4), 403–409. doi:10.5664/jcsm.3616

  • Sikora, D. M., Johnson, K., Clemons, T., & Katz, T. (2012). The relationship between sleep problems and daytime behavior in children of different ages with autism spectrum disorders. Pediatrics, 130(Suppl 2), S83–S90. doi:10.1542/peds.2012-0900F

  • Souders, M. C., Mason, T. B. A., Valladares, O., Bucan, M., Levy, S. E., Mandell, D. S., …, Pinto-Martin, J. (2009). Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep, 32(12), 1566–1578.

    Google Scholar 

  • Stagi, S., Lapi, E., Romano, S., Bargiacchi, S., Brambilla, A., Giglio, S., …, de Martino, M. (2015). Determinants of vitamin d levels in children and adolescents with down syndrome. International Journal of Endocrinology, 2015, 896758. doi:10.1155/2015/896758

  • Sung, M., Chin, C. H., Lim, C. G., Liew, H. S. A., Lim, C. S., Kashala, E., et al. (2014). What’s in the pipeline? Drugs in development for autism spectrum disorder. Neuropsychiatric Disease and Treatment, 10, 371–381. doi:10.2147/NDT.S39516

  • Takaesu, Y., Komada, Y., & Inoue, Y. (2012). Melatonin profile and its relation to circadian rhythm sleep disorders in Angelman syndrome patients. Sleep Medicine, 13(9), 1164–1170. doi:10.1016/j.sleep.2012.06.015

  • Tian, Z., Ye, T., Zhang, X., Liu, E., Wang, W., Wang, P., …, Yu, Z. (2010). Sleep duration and hyperglycemia among obese and nonobese children aged 3 to 6 years. Archives of Pediatrics & Adolescent Medicine, 164(1), 46–52. doi:10.1001/archpediatrics.2009.233

  • Tudor, M. E., Walsh, C. E., Mulder, E. C., & Lerner, M. D. (2015). Pain as a predictor of sleep problems in youth with autism spectrum disorders. Autism: The International Journal of Research and Practice, 19(3), 292–300. doi:10.1177/1362361313518994

  • Wachob, D., & Lorenzi, D. G. (2015). Brief report: Influence of physical activity on sleep quality in children with Autism. Journal of Autism and Developmental Disorders, 45(8), 2641–2646. doi:10.1007/s10803-015-2424-7

  • Weiss, A., Xu, F., Storfer-Isser, A., Thomas, A., Ievers-Landis, C. E., & Redline, S. (2010). The association of sleep duration with adolescents’ fat and carbohydrate consumption. Sleep, 33(9), 1201–1209.

    PubMed  PubMed Central  Google Scholar 

  • Wiggs, L., & Stores, G. (1998). Behavioural treatment for sleep problems in children with severe learning disabilities and challenging daytime behaviour: Effect on sleep patterns of mother and child. Journal of Sleep Research, 7(2), 119–126.

    Article  PubMed  Google Scholar 

  • Wing, Y. K., Li, S. X., Li, A. M., Zhang, J., & Kong, A. P. S. (2009). The effect of weekend and holiday sleep compensation on childhood overweight and obesity. Pediatrics, 124(5), e994–e1000. doi:10.1542/peds.2008-3602

  • Wirojanan, J., Jacquemont, S., Diaz, R., Bacalman, S., Anders, T. F., Hagerman, R. J., et al. (2009). The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine, 5(2), 145–150.

    Google Scholar 

  • Wozniak, J., Mick, E., Waxmonsky, J., Kotarski, M., Hantsoo, L., & Biederman, J. (2009). Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorder. Journal of Child and Adolescent Psychopharmacology, 19(5), 539–545. doi:10.1089/cap.2009.0042

  • Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson-Day, B., Allgar, V., …, Miles, J. (2011). Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: A randomised controlled crossover trial. Journal of Autism and Developmental Disorders, 41(2), 175–184. doi:10.1007/s10803-010-1036-5

  • Yahia, S., El-Farahaty, R. M., El-Hawary, A. K., El-Hussiny, M. A., Abdel-Maseih, H., El-Dahtory, F., et al. (2012). Leptin, insulin and thyroid hormones in a cohort of Egyptian obese down syndrome children: A comparative study. BMC Endocrine Disorders, 12, 22. doi:10.1186/1472-6823-12-22

  • Yamaki, K., Rimmer, J. H., Lowry, B. D., & Vogel, L. C. (2011). Prevalence of obesity-related chronic health conditions in overweight adolescents with disabilities. Research in Developmental Disabilities, 32(1), 280–288. doi:10.1016/j.ridd.2010.10.007

  • Zuckerman, K. E., Hill, A. P., Guion, K., Voltolina, L., & Fombonne, E. (2014). Overweight and obesity: Prevalence and correlates in a large clinical sample of children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 44(7), 1708–1719. doi:10.1007/s10803-014-2050-9

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adelle M. Cadieux .

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Cadieux, A.M. (2017). Medical Comorbidities, Medications, and Sleep. In: Assessing and Treating Pediatric Obesity in Neurodevelopmental Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-55924-7_6

Download citation

Publish with us

Policies and ethics