Abstract
This chapter reviews a publication from our group. It is the first publication of a combined meta-analysis of different classes of study designs. The real data example of 39,505 patients as used, showed, that combining the data from 10 observational and 7 randomized controlled trials provided more power of the pooled outcome, and a larger body of data enabling to consider a secondary outcome, i.e., excess in mortality.
Furthermore, it provided no publication bias, no lack of robustness, and little and clinically unimportant heterogeneity.
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Reference
More information of the meta-analysis of randomized controlled trials is in the Chap. 6, that of the meta-analysis of observational studies is in the Chap. 8.
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Cleophas, T.J., Zwinderman, A.H. (2017). Meta-analysis of Observational Plus Randomized Studies. In: Modern Meta-Analysis. Springer, Cham. https://doi.org/10.1007/978-3-319-55895-0_7
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DOI: https://doi.org/10.1007/978-3-319-55895-0_7
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Online ISBN: 978-3-319-55895-0
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