Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment

  • Carlos EnrichEmail author
  • Carles Rentero
  • Elsa Meneses-Salas
  • Francesc Tebar
  • Thomas Grewal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 981)


Despite the discovery of annexins 40 years ago, we are just beginning to understand some of the functions of these still enigmatic proteins. Defined and characterized by their ability to bind anionic membrane lipids in a Ca2+-dependent manner, each annexin has to be considered a multifunctional protein, with a multitude of cellular locations and diverse activities. Underlying causes for this considerable functional diversity include their capability to associate with multiple cytosolic and membrane proteins. In recent years, the increasingly recognized establishment of membrane contact sites between subcellular compartments opens a new scenario for annexins as instrumental players to link Ca2+ signalling with the integration of membrane trafficking in many facets of cell physiology. In this chapter, we review and discuss current knowledge on the contribution of annexins in the biogenesis and functioning of the late endocytic compartment, affecting endo- and exocytic pathways in a variety of physiological consequences ranging from membrane repair, lysosomal exocytosis, to cell migration.


Annexins AnxA6 Late endosomes Lysosomes Cholesterol Ca2+-signaling Membrane trafficking 



We would like to thank all members of our laboratories, past and present, for their invaluable contributions and apologize to all those researchers whose work could not be discussed owing to space limitations. C.E. was supported by grants from the Ministerio de Economía y Competitividad (BFU2015–66785-P and CSD2009–00016) and Fundació Marató TV3 (PI042182), Spain. T.G. was supported by the University of Sydney (U7042, U7113, RY253, U3367), Sydney, Australia.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Carlos Enrich
    • 1
    • 2
    Email author
  • Carles Rentero
    • 1
    • 2
  • Elsa Meneses-Salas
    • 1
    • 2
  • Francesc Tebar
    • 1
    • 2
  • Thomas Grewal
    • 3
  1. 1.Departament de Biomedicina, Unitat de Biologia Cel·lular, Centre de Recerca Biomèdica (CELLEX)Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)BarcelonaSpain
  2. 2.Facultat de Medicina i Ciències de la SalutUniversitat de BarcelonaBarcelonaSpain
  3. 3.Faculty of PharmacyUniversity of SydneySydneyAustralia

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