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The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains

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Book cover Membrane Dynamics and Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 981))

Abstract

In this chapter the four different genes of the mammalian plasma membrane calcium ATPase (PMCA) and their spliced isoforms are discussed with respect to the structural and functional properties of PMCA, the tissue distribution of the different isoforms, including their differences during development. The importance of PMCA for regulating Ca2+ signaling in microdomains under different conditions is also discussed.

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Acknowledgement

Thanks are due to Marek Michalak for critically reading the manuscript.

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The author declares no conflict of interests.

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    Joachim Krebs

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    Joachim Krebs

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Krebs, J. (2017). The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains. In: Krebs, J. (eds) Membrane Dynamics and Calcium Signaling. Advances in Experimental Medicine and Biology, vol 981. Springer, Cham. https://doi.org/10.1007/978-3-319-55858-5_1

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