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The Plasma Membrane Calcium Pump (PMCA): Regulation of Cytosolic Ca2+, Genetic Diversities and Its Role in Sub-plasma Membrane Microdomains

  • Joachim Krebs
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 981)

Abstract

In this chapter the four different genes of the mammalian plasma membrane calcium ATPase (PMCA) and their spliced isoforms are discussed with respect to the structural and functional properties of PMCA, the tissue distribution of the different isoforms, including their differences during development. The importance of PMCA for regulating Ca2+ signaling in microdomains under different conditions is also discussed.

Keywords

PMCA Ca2+ signaling Calcium homeostasis Second messenger Ca2+ microdomains CaMKIV Alternative splicing 

Notes

Acknowledgement

Thanks are due to Marek Michalak for critically reading the manuscript.

Conflict of Interest

The author declares no conflict of interests.

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Authors and Affiliations

  1. 1.Max Planck Institute for Biophysical ChemistryGöttingenGermany

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