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Wound Treatment by Stem Cells

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Pancreas, Kidney and Skin Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Various experimental or clinical studies in the literature have demonstrated the benefits of stem cells, especially mesenchymal stem cells. This chapter will focus on existing stem cell technologies and their applications in the treatment of wound healing. To understand mechanisms of stem cells in wound healing, we will go over the structure of most commonly wounded tissues, namely, skin, which consist of epithelia and connective tissue. Then we will explain wound healing process with three stages as inflammation, proliferation, and remodeling and the roles of tissue components during wound healing. Treatment of wounds is directly related with the cause, location, and degree of the wound. Therefore, we will describe common wound types with causes under two categories as acute and chronic. We will explain stem cell types which play an important role in tissue regeneration and wound healing in adult life owing to their high competency and self-renewal features. Here, we will give examples of various studies on various wound types with or without underlying diseases. Finally, we will describe recently developed methods such as the use of cells' own products, exosomes, and demonstrate the results of exosome therapies on chronic wounds with most recent examples on human trials.

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Acknowledgements

Authors thank Prof. Dr. Murat AKSOY from Liv Hospital, Istanbul, for his sharing of patient photographs.

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Authors and Affiliations

  1. Department of Biophysics, Istanbul University, Istanbul Faculty of Medicine, 34093, Capa-Istanbul, Turkey

    Leyla Türker Şener & Işil Albeniz

  2. Department of Histology and Embryology, Istinye University Hospital, Faculty of Medicine, 34093, Topkapı-Istanbul, Turkey

    Hakan Darici & Erdal Karaöz

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  1. Leyla Türker Şener
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  2. Hakan Darici
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  3. Işil Albeniz
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  4. Erdal Karaöz
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Correspondence to Erdal Karaöz .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Şener, L.T., Darici, H., Albeniz, I., Karaöz, E. (2017). Wound Treatment by Stem Cells. In: Pham, P. (eds) Pancreas, Kidney and Skin Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-55687-1_10

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