Skip to main content

Nonsmooth Maps and the Fast-Slow Dynamics of Sleep-Wake Regulation: Part I

  • Conference paper
  • First Online:
Book cover Extended Abstracts Spring 2016

Part of the book series: Trends in Mathematics ((RPCRMB,volume 8))

  • 653 Accesses

Abstract

Sleep-wake regulation is an example of a system with multiple timescales, with switching between sleep and wake states occurring in minutes but the states of wake or sleep usually existing for some hours. Here, we discuss some general features of models of sleep-wake regulation. We show that some typical models of sleep-wake regulation can be reduced to one-dimensional maps with discontinuities, and show that this reduction is useful in understanding some of the dynamical behaviour seen in sleep-wake models.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. S.N. Archer, E.E. Laing, C.S. Möller-Levet, D.R. van der Veen, G. Bucca, A.S. Lazar, N. Santhi, A. Slak, R. Kabiljo, M. von Schantz, C.P. Smith, D.J. Dijk, Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc. Natl. Acad. Sci. 111, E682–E691 (2014)

    Article  Google Scholar 

  2. F.P. Cappuccio, L. D’Elia, P. Strazzullo, M.A. Miller, Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33, 585–592 (2010)

    Article  Google Scholar 

  3. S. Daan, D.G.M. Beersma, A.A. Borbély, Timing of human sleep: recovery process gated by a circadian pacemaker. Am. J. Physiol. 246, R161–R178 (1984)

    Google Scholar 

  4. A. Granados, L. AlsedĂ , M. Krupa, The period adding and incrementing bifurcations: from rotation theory to applications. Preprint, arXiv:1407.1895

  5. C.S. Möller-Levet, S.N. Archer, G. Bucca, E. Laing, A. Slak, R. Kabiljo, J. Lo, N. Santhi, M. von Schantz, C.P. Smitth, D.J. Dijk, Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc. Natl. Acad. Sci. 110, E1132–E1141 (2013)

    Article  Google Scholar 

  6. M. Nakao, M. Yamamoto, Bifurcation properties of the two process model. Psychiatry Clin. Neurosci. 52, 131–133 (1998)

    Article  Google Scholar 

  7. A.C. Skeldon, D.J. Dijk, G. Derks, Mathematical models for sleep-wake dynamics: comparison of the two-process model and a mutual inhibition neuronal model. PLoS ONE 10, e103877 (2014)

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank the Centre de Recerca MatemĂ tica for the opportunity to work with each other and other participants of the intensive programme on Advances in Nonsmooth Dynamics. ACS and GD are indebted to Prof. Derk-Jan Dijk of the Surrey Sleep Research Centre at the University of Surrey for introducing them to the area of mathematical modelling of sleep-wake regulation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anne C. Skeldon .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Skeldon, A.C., Derks, G. (2017). Nonsmooth Maps and the Fast-Slow Dynamics of Sleep-Wake Regulation: Part I. In: Colombo, A., Jeffrey, M., Lázaro, J., Olm, J. (eds) Extended Abstracts Spring 2016. Trends in Mathematics(), vol 8. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-55642-0_30

Download citation

Publish with us

Policies and ethics