Skip to main content

Nonlinear Estimation of Synaptic Conductances via Piecewise Linear Systems

  • Conference paper
  • First Online:
  • 658 Accesses

Part of the book series: Trends in Mathematics ((RPCRMB,volume 8))

Abstract

We use the piecewise linear McKean model to present a proof-of-concept to address the estimation of synaptic conductances when a neuron is spiking. Using standard techniques of non-smooth dynamical systems, we obtain an approximation of the period in terms of the parameters of the system which allows to estimate the steady synaptic conductance of the spiking neuron. The method gives also fairly good estimations when the synaptic conductances vary slowly in time.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. L.F. Abbott, A network of oscillators. J. Phys. A: Math General 23(16), 3835 (1990)

    Article  MATH  Google Scholar 

  2. S. Coombes, Neuronal networks with gap junctions: a study of piecewise linear planar neuron models. SIAM J. Appl. Dyn. Syst. 7(3), 1101–1129 (2008)

    Article  MathSciNet  MATH  Google Scholar 

  3. S. Coombes, R. Thul, K.C.A. Wedgwood, Nonsmooth dynamics in spiking neuron models. Phys. D 241(22), 2042–2057 (2012)

    Article  MathSciNet  Google Scholar 

  4. G.B. Ermentrout, D.H. Terman, Mathematical Foundations of Neuroscience (Springer, New York, 2010)

    Book  MATH  Google Scholar 

  5. S. Fernández-García, M. Desroches, M. Krupa, F. Clément, A multiple time scale coupling of piecewise linear oscillators. Application to a neuroendocrine system. SIAM J. Appl. Dyn. Syst. 14, 643–673 (2015)

    Article  MathSciNet  MATH  Google Scholar 

  6. A. Guillamon, D.W. McLaughlin, J. Rinzel, Estimation of synaptic conductances. J. Physiol.-Paris 100(1–3), 31–42 (2006)

    Article  Google Scholar 

  7. A. Tonnelier, W. Gerstner, Piecewise linear differential equations and integrate-and-fire neurons: insights from two-dimensional membrane models. Phys. Rev. E 67, 021908 (2003)

    Article  MathSciNet  Google Scholar 

  8. C. Vich, A. Guillamon, Dissecting estimation of conductances in subthreshold regimes. J. Comput. Neurosci. 39(3), 271–287 (2015)

    Article  MathSciNet  Google Scholar 

Download references

Acknowledgements

This work is partially supported by the Spanish Ministry of Economy and Competitiveness through project MTM2015-71509-C2-2-R (AG), by the MCYT/FEDER grant number MTM2014-54275-P (RP, AT and CV) and by the Government of Catalonia under grant 2014-SGR–504 (AG).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Antoni Guillamon .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Guillamon, A., Prohens, R., Teruel, A.E., Vich, C. (2017). Nonlinear Estimation of Synaptic Conductances via Piecewise Linear Systems. In: Colombo, A., Jeffrey, M., Lázaro, J., Olm, J. (eds) Extended Abstracts Spring 2016. Trends in Mathematics(), vol 8. Birkhäuser, Cham. https://doi.org/10.1007/978-3-319-55642-0_16

Download citation

Publish with us

Policies and ethics