Abstract
Background: Marijuana is the most widely used illicit substance in the USA and self-reported use has remained steady over the past decade. Numerous publications examine the influence of marijuana use on various facets of human physiology including neurocognitive function, immune function, and illness symptom control, each discussing marijuana’s influence in a narrow or compartmentalized fashion. However, there is a scant literature discussing the empirical and clinical implications of the intersection of these constructs. The primary objective of this review is to review and synthesize this disparate literature and propose future research directions. Thus, this review examines the literature that relates the influence of marijuana to: (1) neurocognitive function; (2) immune function; (3) treatment uses; and (4) propose future directions.
Methods: Clinical and nonclinical empirical studies were collected and utilized to inform this review. The authors used PubMed search engine as the primary mechanism used to identify relevant articles.
Conclusion: Given the legalization efforts of recreational marijuana use, there is a need to discuss health and treatment effects of marijuana use from a more comprehensive, psychoneuroimmunological or biopsychosocial framework. We will discuss the need for an interdisciplinary research and future steps regarding the examination of marijuana use.
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References
Substance Abuse and Mental Health Services Administration: Substance Abuse and Mental Health Services Administration, Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. (SMA) 14-4863. Rockville, MD (2014)
National Institute on Drug Abuse: Marijuana Retrieved from http://www.drugabuse.gov/publications/drugfacts/marijuana on August 6, 2015
Vincent, B.J., McQuiston, D.J., Einhorn, L.H., Nagy, C.M., Brames, M.J.: Review of cannabinoids and their antiemetic effectiveness. Drugs. 25, 52–62 (1983)
Li, H.L.: An archaeological and historical account of cannabis in China. Econ. Bot. 28(4), 437–448 (1973)
Ben Amar, M.: Cannabinoids in medicine: a review of their therapeutic potential. J. Ethnopharmacol. 105(1), 1–25 (2006)
Pacula, R.L.: Marijuana use and policy: What we know and have yet to learn. NBER Reporter Online, (Winter 2004/05), 22–24 (2004)
Hall, W., Degenhardt, L.: Adverse health effects of non-medical cannabis use. Lancet. 374(9698), L1383–L1391 (2009)
Hall, W.D., Lynskey, M.: Is cannabis a gateway drug? Testing hypotheses about the relationship between cannabis use and the use of other illicit drugs. Drug Alcohol Rev. 24(1), 39–48 (2005)
Morral, A.R., McCaffrey, D.F., Paddock, S.M.: Reassessing the marijuana gateway effect. Addiction. 97(12), 1493–1504 (2002)
Raphael, B., Wooding, S., Stevens, G., Connor, J.: Comorbidity: cannabis and complexity. J. Psychiatr. Pract. 11(3), 161–176 (2005)
Tan, W.C., Lo, C., Jong, A., Xing, L., FitzGerald, M.J., Vollmer, W.M., Buist, S.A., Sin, D.D., Vancouver Burden of Obstructive Lung Disease (BOLD) Research Group: Marijuana and chronic obstructive lung disease: a population-based study. Can. Med. Assoc. J. 180(8), 814–820 (2009)
Lundvquist, T.: Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions. Pharmacol. Biochem. Behav. 81, 319–330 (2005)
Cousijn, J., Wiers, R.W., Ridderinkhof, K.R., Brink, W., Veltman, D.J., Porrino, L.J., Goudriaan, A.E.: Individual differences in decision making and reward processing predict changes in cannabis use: a prospective functional magnetic resonance imaging study. Addict. Biol. 18(6), 1013–1023 (2013)
Klein, T.W., Friedman, H., Specter, S.: Marijuana, immunity and infection. J. Neuroimmunol. 83(1), 102–115 (1998)
Jemmott, J.B., Locke, S.E.: Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: how much do we know? Psychol. Bull. 95(1), 78 (1984)
Maier, S.F., Watkins, L.R.: Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol. Rev. 105(1), 83 (1998)
Suls, J., Rothman, A.: Evolution of the biopsychosocial model: prospects and challenges for health psychology. Health Psychol. 23(2), 119 (2004)
ElSohly, M.A.: Marijuana and The Cannabinoids. Humana Press, Totowa, New Jersey (2007)
Rom, S., Persidsky, Y.: Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation. J. NeuroImmune Pharmacol. 8(3), 608–620 (2013)
Bhattacharyya, S., Fusar-Poli, P., Borgwardt, S., et al.: Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. Arch. Gen. Psychiatry. 66(4), 442–451 (2009)
Schoeler, T., Bhattacharyya, S.: The effect of cannabis use on memory function: an update. Subst. abuse Rehabil. 4, 11–27 (2013)
Crane, N.A., Schuster, R.M., Fusar-Poli, P., Gonzalez, R.: Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences. Neuropsychol. Rev. 23(2), 117–137 (2013)
Fernández-Serrano, M.J., PĂ©rez-GarcĂa, M., Verdejo-GarcĂa, A.: What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance? Neurosci. Biobehav. Rev. 35(3), 377–406 (2011)
Wright, M.J., Vandewater, S.A., Taffe, M.A.: Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ9tetrahydrocannabinol. Br. J. Pharmacol. 170(7), 1365–1373 (2013)
Thames, A.D., Arbid, N., Sayegh, P.: Cannabis use and neurocognitive functioning in a non-clinical sample of users. Addict. Behav. 39(5), 994–999 (2014)
Behan, B., Connolly, C.G., Datwani, S., Doucet, M., Ivanovic, J., Morioka, R., Stone, A., Watts, R., Smyth, B., Garavan, H.: Response inhibition and elevated parietal-cerrebellar correlations in chronic adolescent cannabis users. Neuropharmacology. 84, 131–137 (2014)
Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R., Rice, K.C.: Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. U. S. A. 87(5), 1932–1936 (1990)
Vik, P.W., Cellucci, T., Jarchow, A., Hedt, J.: Cognitive impairment in substance abuse. Psychiatr. Clin. N. Am. 27(1), 97–109 (2004)
Gonzalez, R.: Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. Neuropsychol. Rev. 17, 347–361 (2007)
Ranganathan, M., D’Souza, D.C.: The acute effects of cannabinoids on memory in humans: a review. Psychopharmacology. 188, 425–444 (2006)
Mathew, R.J., Wilson, W.H.: Substance abuse and cerebral blood flow. Am. J. Psychiatry. 148, 292–305 (1991)
Mathew, R.J., Wilson, W.H., Coleman, R.E., Turkington, T.G., DeGrado, T.R.: Marijuana intoxication and brain activation in marijuana smokers. Life Sci. 60(23), 2075–2089 (1997)
Mathew, R.J., Wilson, W.H., Chiu, N.Y., Turkington, T.G., Coleman, R.E.: Regional cerebral blood flow and depersonalization after tetrahydrocannabinol adminstration. Acta Psychiatr. Scand. 100, 67–75 (1999a)
Mathew, R.J., Wilson, W.H., Turkington, T.G., Coleman, R.E.: Cerebellar activity and disturbed time sense after THC. Brain Res. 797, 183–189 (1999b)
Volkow, N.D., Gillespie, H., Mullani, N., Tancredi, L., Grant, C., Valentine, A., Holister, L.: Brain glucose metabolism in chronic marijuana users at baseline and during intoxication. Psychiatr. Res. Neuroimaging. 67, 29–38 (1996)
Block, R.I., O’Leary, D.S., Hichwa, R.D., Augustinack, J.C., Boles Ponto, L.L., Ghoneim, M.M., Arndt, S., Hurtig, R.R., Watkins, G.L., Hall, J.A., Nathan, P.E.: Effects of frequent marijuana use on memory-related regional cerebral blood flow. Pharmacol. Biochem. Behav. 72, 237–250 (2002)
Eldreth, D.A., Matochik, J.A., Cadet, J.L., Bolla, K.I.: Abnormal brain activity in prefrontal brain regions in abstinent marijuana users. NeuroImage. 23(3), 914–920 (2004)
Jager, G., Block, R.I., Luijten, M., Ramsey, N.F.: Cannabis use and memory brain function in adolescent boys: a cross-sectional multicenter functional magnetic resonance imaging study. J. Am. Acad. Child Adolesc. Psychiatry. 49, 561–572 (2010)
Kanayama, G., Rogowska, J., Pope, H.G., Gruber, S.A., Yurgelynn-Todd, D.A.: Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology. 176, 239–247 (2004)
Tapert, S.F., Schweinsburg, A.D., Drummond, S.P., Paulus, M.P., Brown, S.A., Yang, T.T., Frank, L.R.: Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology. 194, 173–183 (2007)
Bossong, M.G., Jager, G., Bhattacharyya, S., Allen, P.: Acute and non-acute effects of Cannabis on human memory function: a critical review of neuroimaging studies. Curr. Pharm. Des. 20(13), 2114–2125 (2014)
Abdullaez, Y., Posner, M.I., Nunnally, R., Dishion, T.J.: Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. Behav. Brain Res. 215, 45–47 (2010)
Medina, K.L., Schweinsburg, A.D., Cohen-Zion, M., Nagel, B.J., Tapert, S.F.: Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. Neurotoxicol. Teratol. 29, 141–152 (2007)
Solowij, N., Michie, P.T., Fox, A.M.: Differential impairments of selective attention due to frequency and duration of cannabis use. Biol. Psychiatry. 15, 731–739 (1995)
Solowij, N., Stephens, R., Roffman, R., Babor, T., Kadden, R., Miller, M., Christiansen, K., McRee, B., Vendetti, J., The Marijuana Project Research Group: Cognitive functioning of long-term heavy cannabis users seeking treatment. J. Am. Med. Assoc. 287, 1123–1131 (2002)
Dougherty, D.M., Mathias, C.W., Dawes, M.A., Furr, R.M., Charles, N.E., Liguori, A., Shannon, E.E., Acheson, A.: Impulsivity, attention, memory, and decision-making among adolescent marijuana users. Psychopharmacology. 226(2), 307–319 (2013)
Hanson, K.L., Winward, J.L., Schweinsburg, A.D., Medina, K.L., Brown, S.A., Tapert, S.F.: Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addict. Behav. 35, 970–976 (2010)
Harvey, M.A., Sellman, J.D., Porter, R.J., Frampton, C.M.: The relationship between non-acute adolescent cannabis use and cognition. Drug Alcohol Rev. 26, 309–319 (2007)
Lisdahl, K.M., Price, J.S.: Increased marijuana use and gender predict poorer cognitive functioning in adolescents and emerging adults. J. Int. Neuropsychol. Soc. 18, 678–688 (2012)
Mathias, C.W., Blumenthal, T.D., Dawes, M.A., Liguori, A., Richard, D.M., Bray, B., Tong, W., Dougherty, D.M.: Failure to sustain prepulse inhibition in adolescent marijuana users. Drug Alcohol Depend. 116, 110–116 (2011)
McHale, S., Hunt, N.: Executive function deficits in short-term abstinent cannabis users. Hum. Psychopharmacol. Clin. Exp. 23, 409–415 (2008)
Tapert, S.F., Granholm, E., Leedy, N.G., Brown, S.A.: Substance use and withdrawal: neuropsychological functioning over 8 years in youth. J. Int. Neuropsychol. Soc. 8, 873–883 (2002)
Battisti, R.A., Roodenrys, S., Johnstone, S.J., Pesa, N., Hermens, D.F., Solowij, N.: Chronic cannabis user show altered neurophysiological functioning on Stroop task conflict resolution. Psychopharmacology. 212, 613–624 (2010)
Day, A.M., Metrik, J., Spillane, N.S., Kahler, C.W.: Working memory and impulsivity predict marijuana-related problems among frequent users. Drug Alcohol Depend. 131(1), 171–174 (2013)
Gonzalez, R., Schuster, R.M., Mermelstein, R.J., Vassileva, J., Martin, E.M., Diviak, K.R.: Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders. J. Clin. Exp. Neuropsychol. 34, 962–976 (2012)
Grant, J.E., Chamberlain, S.R., Schreiber, L., Odlaug, B.L.: Neuropsychological deficits associated with cannabis use in young adults. Drug Alcohol Depend. 121, 159–162 (2012)
Pope, H.G., Yurgelun-Todd, D.: The residual cognitive effects of heavy marijuana use in college students. J. Am. Med. Assoc. 275, 521–527 (1996)
Schuster, R.M., Crane, N.A., Mermelstein, R., Gonzalez, R.: The influence of inhibitory control and episodic memory on the risky sexual behavior of young adult cannabis users. J. Int. Neuropsychol. Soc. 18, 827–833 (2012)
Solowij, N., Jones, K.A., Rozman, M.E., Davis, S.M., Ciarrochi, J., Heaven, P.C., Pesa, N., Lubman, D.I., Yücel, M.: Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents. Psychopharmacology. 219, 575–586 (2012)
Kalant, H.: Adverse effects of cannabis on health: an update of the literature since 1996. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 28(5), 849–863 (2004)
Lyketsos, C.G., Garrett, E., Liang, K.Y., Anthony, J.C.: Cannabis use and cognitive decline in persons under 65 years of age. Am. J. Epidemiol. 149(9), 749–800 (1999)
Pope Jr., H.G., Gruber, A.J., Hudson, J.I., Huestis, M.A., Yurgelun-Todd, D.: Neurpsychological performance in long-term cannabis users. Arch. Gen. Psychiatry. 58(10), 909–915 (2001)
Bolla, K.I., Brown, K., Eldreth, D., Tate, K., Cadet, J.L.: Dose-related neurocognitive effects of marijuana use. Neurology. 59(9), 1337–1343 (2002)
Wagner, D., Becker, B., Gouzoulis-Mayfrank, E., Daumann, J.: Interactions between specific parameters of cannabis use and verbal memory. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 34, 871–876 (2010)
Becker, B., Wagner, D., Gouzoulis-Mayfrank, E.S., Daumann, J.: The impact of early-onset cannabis use on functional brain correlates of working memory. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 34, 837–845 (2010)
Rieder, S.A., Chauhan, A., Singh, U., Nagarkatti, M., Nagarkatti, P.: Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. 215(8), 598–605 (2010)
Suárez-Pinilla, P., López-Gil, J., Crespo-Facorro, B.: Immune system: a possible nexus between cannabinoids and psychosis. Brain Behav. Immun. 40, 269–282 (2014)
Klein, T.W., Newton, C., Larsen, K., Lu, L., Perkins, I., Nong, L., Friedman, H.: The cannabinoid system and immune modulation. J. Leukoc. Biol. 74(4), 486–496 (2003)
Crowe, M.S., Nass, S.R., Gabella, K.M., Kinsey, S.G.: The endocannabinoid system modulates stress, emotionality, and inflammation. Brain Behav. Immun. 42, 1–5 (2014)
Herbert, T.B., Cohen, S.: Stress and immunity in humans: a meta-analytic review. Psychosom. Med. 55(4), 364–379 (1993)
Pestonjamasp, V.K., Burstein, S.H.: Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. Biochim. Biophys. Acta (BBA) Lipids Lipid Metab. 1394(2), 249–260 (1998)
Croxford, J.L., Yamamura, T.: Cannabinids and the immune system: potential for the treatment of inflammatory diseases? J. Neuroimmunol. 165, 3–18 (2005)
Munro, S., Thomas, K.L., Abu-Shaar, M.: Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365, 61–65 (1993)
Miller, A.M., Stella, N.: CB2 receptor mediated migration of immune cells: it can go either way. Br. J. Pharmacol. 153(2), 299–308 (2008)
Malfait, A.M., Gallily, R., Sumariwalla, P.F., Malik, A.S., Andreakos, E., Mechoulam, R., Feldmann, M.: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. 97(17), 9561–9566 (2000)
Klein, T.W., Newton, C., Friedman, H.: Cannabinoid receptors and immunity. Immunol. Today. 19(8), 373–381 (1998)
Specter, S., Lancz, G., Hazelden, J.: Marijuana and immunity: tetrahydrocannabinol mediated inhibition of lymphocyte blastogenesis. Int. J. Immunopharmacol. 12(3), 261–267 (1990)
Baldwin, G.C., Tashkin, D.P., Buckley, D.M., Park, A.N., Dubinett, S.M., Roth, M.D.: Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am. J. Respir. Crit. Care Med. 156(5), 1606–1613 (1997)
Keen II, L., Turner, A.D.: Differential effects of self-reported lifetime marijuana use on interleukin-1 alpha and tumor necrosis factor in African American adults. J. Behav. Med. 38, 527–534 (2015)
Keen, L., Pereira, D., Latimer, W.: Self-reported lifetime marijuana use and interleukin-6 levels in middle-aged African Americans. Drug Alcohol Depend. 140, 156–160 (2014)
Kozela, E., Juknat, A., Kaushansky, N., Rimmerman, N., Ben-Nun, A., Vogel, Z.: Cannabinoids decrease the 17th inflammatory autoimmune phenotype. J. NeuroImmune Pharmacol. 8(5), 1265–1276 (2013)
Roth, M.D., Arora, A., Barsky, S.H., Kleerup, E.C., Simmons, M., Tashkin, D.P.: Airway inflammation in young marijuana and tobacco smokers. Am. J. Respir. Crit. Care Med. 157(3), 928–937 (1998)
Pacifici, R., Zuccaro, P., Pichini, S., Roset, P.N., Poudevida, S., Farré, M., Segura, J., de la Torre, R.: Modulation of the immune system in cannabis users. JAMA. 289(15), 1929–1931 (2003)
Pacifici, R., Zuccaro, P., Farré, M., Poudevida, S., Abanades, S., Pichini, S., Langohr, K., Segura, J., De La Torre, R.: Combined immunomodulating properties of 3, 4-methylenedioxymethamphetamine (MDMA) and cannabis in humans. Addiction. 102(6), 931–936 (2007)
Roth, M.D., Whittaker, K., Salehi, K., Tashkin, D.P., Baldwin, G.C.: Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers. J. Neuroimmunol. 147(1), 82–86 (2004)
Monnet-Tschudi, F., Hazekamp, A., Perret, N., Zurich, M.G., Mangin, P., Giroud, C., Honegger, P.: Delta-9-tetrahydrocannabinol accumulation, metabolism and cell-type-specific adverse effects in aggregating brain cell cultures. Toxicol. Appl. Pharmacol. 228(1), 8–16 (2008)
Kozela, E., Pietr, M., Juknat, A., Rimmerman, N., Levy, R., Vogel, Z.: Cannabinoids Δ9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-κB and interferon-β/STAT proinflammatory pathways in BV-2 microglial cells. J. Biol. Chem. 285(3), 1616–1626 (2010)
Roth, M.D., Baldwin, G.C., Tashkin, D.P.: Effects of delta-9-tetrahydrocannabinol on human immune function and host defense. Chem. Phys. Lipids. 121(1), 229–239 (2002)
Ongrandi, J., Spector, S., Horvath, A., Friedman, H.: Combined in vitro effect of marijuana and retrovirus on the activity of mouse natural killer cells. Pathol. Oncol. Res. 4(3), 191–199 (1998)
Ngaotepprutaram, T., Kaplan, B.L., Kaminski, N.E.: Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ 9-tetrahydrocannabinol in human CD4+ T cells. Toxicol. Appl. Pharmacol. 273(1), 209–218 (2013)
Srivastava, M.D., Srivastava, B.I.S., Brouhard, B.: Δ 9 Tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology. 40(3), 179–185 (1998)
Yuan, M., Kiertscher, S.M., Cheng, Q., Zoumalan, R., Tashkin, D.P., Roth, M.D.: Δ 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J. Neuroimmunol. 133(1), 124–131 (2002)
Klein, T.W., Newton, C., Larsen, K., Chou, J., Perkins, I., Lu, L., Nong, L., Friedman, H.: Cannabinoid receptors and T helper cells. J. Neuroimmunol. 147(1), 91–94 (2004)
Roth, M.D., Castaneda, J.T., Kiertscher, S.M.: Exposure to Δ9-tetrahydrocannabinol impairs the differentiation of human monocyte-derived dendritic cells and their capacity for T cell activation. J. NeuroImmune Pharmacol. 10(2), 333–343 (2015)
Fischer-Stenger, K., Pettit, D.D., Cabral, G.A.: Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events. J. Pharmacol. Exp. Ther. 267(3), 1558–1565 (1993)
Kusher, D.I., Dawson, L.O., Taylor, A.C., Djeu, J.Y.: Effect of the psychoactive metabolite of marijuana delta9-tetrahydrocannabinol (thc), on the synthesis of tumor necrosis factor by human large granular lymphocites. Cell. Immunol. 154, 99–108 (1994)
Snella, E., Pross, S., Friedman, H.: Relationship of aging and cytokines to the immunomodulation by delta-9-tetrahydrocannabinol on murine lymphoid cells. Int. J. Immunopharmacol. 17(12), 1045–1054 (1995)
Wang, M., Richards, A.L., Friedman, H., Djeu, J.Y.: Selective inhibition of natural killer but not natural cytotoxic activity in a cloned cell line by delta-9-tetrahydrocannabinol. J. Leukoc. Biol. 50(2), 192–197 (1991)
Newton, C.A., Klein, T.W., Friedman, H.: Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect. Immun. 62(9), 4015–4020 (1994)
Massi, P., Sacerdote, P., Ponti, W., Fuzio, D., Manfredi, B., Viganó, D., Rubino, T., Bardotti, M., Parolaro, D.: Immune function alterations in mice tolerant to Δ 9-tetrahydrocannabinol: functional and biochemical parameters. J. Neuroimmunol. 92(1), 60–66 (1998)
Klein, T.W., Newton, C.A., Nakachi, N., Friedman, H.: Δ9-tetrahydrocannabinol treatment suppresses immunity and early IFN-γ, IL-12, and IL-12 receptor β2 responses to Legionella pneumophila infection. J. Immunol. 164(12), 6461–6466 (2000)
Newton, C.A., Lu, T., Nazian, S.J., Perkins, I., Friedman, H., Klein, T.W.: The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J. Leukoc. Biol. 76(4), 854–861 (2004)
Gaffal, E., Cron, M., Glodde, N., Tüting, T.: Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy. 68(8), 994–1000 (2013)
Zhu, L.X., Sharma, S., Stolina, M., Gardner, B., Roth, M.D., Tashkin, D.P., Dubinett, S.M.: Δ-9-Tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J. Immunol. 165(1), 373–380 (2000)
Chang, Y.H., Lee, S.T., Lin, W.W.: Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. J. Cell. Biochem. 81(4), 715–723 (2001)
Lu, T., Newton, C., Perkins, I., Friedman, H., Klein, T.W.: Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J. Pharmacol. Exp. Ther. 319(1), 269–276 (2006)
Verhoeckx, K.C., Korthout, H.A., van Meeteren-Kreikamp, A.P., Ehlert, K.A., Wang, M., van der Greef, J., Rodenburg, R.J., Witkamp, R.F.: Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB 1 and CB 2 receptor coupled pathways. Int. Immunopharmacol. 6(4), 656–665 (2006)
McKallip, R.J., Nagarkatti, M., Nagarkatti, P.S.: Δ-9-Tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J. Immunol. 174(6), 3281–3289 (2005)
Ramarathinam, L., Pross, S., Plescia, O., Newton, C., Widen, R., Friedman, H.: Differential immunologic modulatory effects of tetrahydrocannabinol as a function of age. Mech. Ageing Dev. 96(1), 117–126 (1997)
Alshaarawy, O., Anthony, J.C.: Cannabis smoking and serum C-reactive protein: a quantile regressions approach based on NHANES 2005–2010. Drug Alcohol Depend. 147, 203–207 (2015)
Muniyappa, R., Sable, S., Ouwerkerk, R., Mari, A., Gharib, A.M., Walter, M., Courville, A., Hall, G., Chen, K.Y., Volkow, N.D., Kunos, G.: Metabolic effects of chronic cannabis smoking. Diabetes Care. 36(8), 2415–2422 (2013)
Costello, E.J., Copeland, W.E., Shanahan, L., Worthman, M., Angold, A.: C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis. Drug Alcohol Depend. 133(2), 712–717 (2013)
Rajavashisth, T.B., Shaheen, M., Norris, K.C., Pan, D., Sinha, S.K., Ortega, J., Friedman, T.C.: Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2(1), e000494 (2012)
Ugen, K.E., Nyland, S.B.: Injecting drugs of abuse and immunity: implications for HIV vaccine testing and efficacy. Semin. Immunopathol. 28(3), 281–287 (2006)
Cescon, D.W., Page, A.V., Richardson, S., Moore, M.J., Boerner, S., Gold, W.L.: Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer. J. Clin. Oncol. 26(13), 2214–2215 (2008)
Ruchlemer, R., Amit-Kohn, M., Raveh, D., Hanuš, L.: Inhaled medicinal cannabis and the immunocompromised patient. Support. Care Cancer. 23(3), 819–822 (2015)
Szyper-Kravitz, M., Lang, R., Manor, Y., Lahav, M.: Early invasive pulmonary aspergillosis in a leukemia patient linked to aspergillus contaminated marijuana smoking. Leuk. Lymphoma. 42(6), 1433–1437 (2001)
Cabral, G.A., Pettit, D.A.D.: Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J. Neuroimmunol. 83(1), 116–123 (1998)
Huemer, H.P., Lassnig, C., Bernhard, D., Sturm, S., Nowotny, N., Kitchen, M., Pavlic, M.: Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus. Immunobiology. 216(6), 670–677 (2011)
Lee, M.A.: The Discovery of the Endocannabinoid system. Retrieved from http://www.beyondthc.com/wp-content/uploads/2012/07/eCBSystemLee.pdf (2010)
Fischer, B., Murphy, Y., Kurdyak, P., Goldner, E., Rehm, J.: Medical Marijuana Programs-why might they matter for public health and why should we better understand their impacts? Prev. Med. Rep. 2, 53–56 (2015)
Philipsen, N., Butler, R.D., Simon-Waterman, C., Artis, J.: Medical marijuana: a primer on ethics, evidence, and politics. J. Nurse Pract. 10(9), 633–640 (2014)
Klein, T.W.: Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat. Rev. Immunol. 5(5), 400–411 (2005)
Klein, T.W., Cabral, G.A.: Cannabinoid-induced immune suppression and modulation of antigen-presenting cells. J. NeuroImmune Pharmacol. 1(1), 50–64 (2006)
Sylvestre, D.L., Clements, B.J., Malibu, Y.: Cannabis use improves retention and virological outcomes in patients treated for hepatitis C. Eur. J. Gastroenterol. Hepatol. 18(10), 1057–1063 (2006)
Lorente, M., Torres, S., Salazar, M., Carracedo, A., Hernández-Tiedra, S., RodrĂguez-FornĂ©s, F., Garcia-Taboada, E., MelĂ©ndez, B., Mollejo, M., Campos-Martin, Y., Lakatosh, S.A.: Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 18(6), 959–973 (2011)
Naftali, T., Lev, L.B., Yablecovitch, D., Half, E., Konikoff, F.M.: Treatment of Crohn’s disease with cannabis: an observational study. Isr. Med. Assoc. J. 13(8), 455–458 (2011)
Waldman, M., Hochhauser, E., Fishbein, M., Aravot, D., Shainberg, A., Sarne, Y.: An ultra-low dose of tetrahydrocannabinol provides cardioprotection. Biochem. Pharmacol. 85(11), 1626–1633 (2013)
Maier, S.F., Watkins, L.R., Fleshner, M.: Psychoneuroimmunology: the interface between behavior, brain, and immunity. Am. Psychol. 49(12), 1004 (1994)
Schreiner, A.M., Dunn, M.E.: Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis. Exp. Clin. Psychopharmacol. 20, 420–429 (2012)
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This project was supported by grant #P20 MD000512 from National Center on Minority Health and Health Disparities.
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Drs. Keen II, Turner, Pereira, Callender, and Campbell contributed to the literature search and writing/editing of this article and have approved the final article.
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Keen, L., Turner, A.D., Pereira, D., Callender, C., Campbell, A. (2017). The Psychoneuroimmunological Influences of Recreational Marijuana. In: Toni, B. (eds) New Trends and Advanced Methods in Interdisciplinary Mathematical Sciences. STEAM-H: Science, Technology, Engineering, Agriculture, Mathematics & Health. Springer, Cham. https://doi.org/10.1007/978-3-319-55612-3_5
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