Abstract
In living organisms different developmental and environmental stimuli can trigger Ca2+ transients of specific signature that can modulate gene expression and metabolism. Mitochondria play an important role in shaping intracellular calcium dynamics. Recently, several molecular players involved in mitochondrial Ca2+ signalling have been identified both in animals and plants, including those of the mitochondrial Ca2+ uniporter complex, MCUC. In he present review the significance of mitochondrial Ca2+ control is discussed in the light of the cytosolic calcium signalling and of specific metabolic and energetic needs of different organisms.
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Acknowledgments
The authors are grateful for financial support by the Italian Association for Cancer Research (15544 to I.S. and 10016 to R.R.), the Italian Ministry (Progetti di Rilevanza Nazionale PRIN 2015795S5W to I.S.), the French Muscular Dystrophy Association (19471 to A.R.), and the European Research Council (ERC mitoCalcium no. 294777 to R.R.).
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Checchetto, V., De Stefani, D., Raffaello, A., Rizzuto, R., Szabo, I. (2017). Molecular Players of Mitochondrial Calcium Signaling: Similarities and Different Aspects in Various Organisms. In: Rostovtseva, T. (eds) Molecular Basis for Mitochondrial Signaling. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-55539-3_2
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