An Online Platform for the Automatic Reporting of Multi-parametric Tissue Signatures: A Case Study in Glioblastoma

  • Javier Juan-AlbarracínEmail author
  • Elies Fuster-Garcia
  • Juan M. García-Gómez
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10154)


Glioblastomas are infiltrative and deeply invasive neoplasms characterized by high vascular proliferation and diffuse margins. As a consequence, this lesion presents a high degree of heterogeneity that requires being studied through a multiparametric combination of several imaging sequences. Nowadays few systems are available to perform a relevant multiparametric analysis of this tumour. In this work, we present the study of GBM by means of, an online platform for the automatic reporting of multiparametric tissue signatures. The platform implements two full automated GBM pipelines: (1) the anatomical pipeline, which involves MRI preprocessing and tumour segmentation; and (2) the hemodynamic MTS pipeline, which adds the quantification of perfusion parameters and a nosologic segmentation map of the vascular habitats of the GBM. A radiologic report summarizes the findings of both analysis and provides volumetric and perfusion statistics of each tissue and habitat of the tumour.


Glioblastoma Segmentation Perfusion quantification Vascular habitats On-line service 



This work was partially supported by project TIN2013-43457-R: Caracterización de firmas biológicas de glioblastomas mediante modelos no-supervisados de predicción estructurada basados en biomarcadores de imagen, co-funded by the Ministerio de Economía y Competitividad of Spain; by project DPI2016-80054-R: Biomarcadores dinamicos basados en firmas tisulares multiparametricas para el seguimiento y evaluacion de la respuesta a tratamiento de pacientes con glioblastoma y cancer de prostata; by project Spanish EIT Proof of Concept grant (PoC-2016-SPAIN-07) entitled MULTIBIOIM: Multiparametric nosological images for supporting clinical decisions in solid tumors; by project CON2016-C05 UPV-IISLaFe: Inclusión de las tecnologías de firma tisular y modelos mutiescala para el soporte a la planificación de la radioterapia en el tratamiento del glioblastoma, funded by Instituto de Investigación Sanitaria H. Universitario y Politécnico La Fe; by project CON2014002 UPV-IISLaFe: Empleo de segmentación no supervisada multiparamétrica basada en perfusión RM para la caracterización del edema peritumoral de gliomas y metástasis cerebrales únicas, funded by Instituto de Investigación Sanitaria H. Universitario y Politécnico La Fe; and by Instituto de Aplicaciónes de las Tecnologías de la Información y las Comunicaciones Avanzadas (ITACA). E. Fuster-Garcia acknowledges the financial support from the program PAID- 10-14: Ayudas para la Contratación de Doctores para el Acceso al SECTI founded by the Universitat Politécnica de Valéncia.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Javier Juan-Albarracín
    • 1
    Email author
  • Elies Fuster-Garcia
    • 1
  • Juan M. García-Gómez
    • 1
  1. 1.Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA)Universitat Politècnica de ValènciaValenciaSpain

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