Abstract
Long intergenic noncoding RNAs (lincRNAs) are generally long transcripts of more than 200 nucleotide (nt) that lack a coding sequence (CDS) or open reading frame (ORF); now the functions of plant lincRNAs remain largely unknown. In this chapter, we describe a computational pipeline to identify the function of lincRNAs based on the relationship between miRNAs and lincRNAs. In our method, lincRNA–mRNA co-expression networks and the ceRNA hypothesis are used to infer the function of lincRNAs as miRNA targets and lincRNAs as miRNA decoys, respectively.
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References
Addo-Quaye C, Miller W, Axtell MJ (2009) CleaveLand: a pipeline for using degradome data to find cleaved small RNA targets. Bioinformatics 25:130–131
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
Boerner S, McGinnis KM (2012) Computational identification and functional predictions of long noncoding RNA in Zea mays. PLoS One 7:e43047
Conesa A, Gotz S, Garcia-Gomez JM et al (2005) Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21:3674–3676
Ding Y, Tao Y, Zhu C (2013) Emerging roles of microRNAs in the mediation of drought stress response in plants. J Exp Bot 64:3077–3086
Fan C, Hao Z, Yan J, Li G (2015) Genome-wide identification and functional analysis of lincRNAs acting as miRNA targets or decoys in maize. BMC Genomics 16:793
Franco-Zorrilla JM, Valli A, Todesco M et al (2007) Target mimicry provides a new mechanism for regulation of microRNA activity. Nat Genet 39:1033–1037
Guttman M, Rinn JL (2012) Modular regulatory principles of large non-coding RNAs. Nature 482:339–346
Hao Z, Fan C, Cheng T et al (2015) Genome-wide identification, characterization and evolutionary analysis of long intergenic noncoding RNAs in cucumber. PLoS One 10:e0121800
Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559
Li L, Eichten SR, Shimizu R et al (2014) Genome-wide discovery and characterization of maize long non-coding RNAs. Genome Biol 15:R40
Liang H, Zhang J, Zen K et al (2013) Nuclear microRNAs and their unconventional role in regulating non-coding RNAs. Protein Cell 4:325–330
Liu J, Jung C, Xu J et al (2012) Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell 24:4333–4345
Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: insights into functions. Nat Rev Genet 10:155–159
Ponting CP, Oliver PL, Reik W (2009) Evolution and functions of long noncoding RNAs. Cell 136:629–641
Rhoades MW, Reinhart BJ, Lim LP et al (2002) Prediction of plant microRNA targets. Cell 110:513–520
Salmena L, Poliseno L, Tay Y et al (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146:353–358
Shannon P, Markiel A, Ozier O et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498–2504
Wu HJ, Wang ZM, Wang M et al (2013) Widespread long noncoding RNAs as endogenous target mimics for microRNAs in plants. Plant Physiol 161:1875–1884
Zhang W, Han Z, Guo Q et al (2014) Identification of maize long non-coding RNAs responsive to drought stress. PLoS One 9:e98958
Zhu QH, Wang MB (2012) Molecular functions of long non-coding RNAs in plants. Genes 3:176–190
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Li, G., Hao, Z., Fan, C., Wu, X. (2017). Genome-Wide Function Analysis of lincRNAs as miRNA Targets or Decoys in Plant. In: Rajewsky, N., Jurga, S., Barciszewski, J. (eds) Plant Epigenetics. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-55520-1_8
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DOI: https://doi.org/10.1007/978-3-319-55520-1_8
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