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Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury

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Mitochondrial Dynamics in Cardiovascular Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 982))

Abstract

Ischemic heart disease remains the leading cause of death worldwide. Mitochondria are the power plant of the cardiomyocyte, generating more than 95% of the cardiac ATP. Complex cellular responses to myocardial ischemia converge on mitochondrial malfunction which persists and increases after reperfusion, determining the extent of cellular viability and post-ischemic functional recovery. In a quest to ameliorate various points in pathways from mitochondrial damage to myocardial necrosis, exhaustive pharmacologic and genetic tools have targeted various mediators of ischemia and reperfusion injury and procedural techniques without applicable success. The new concept of replacing damaged mitochondria with healthy mitochondria at the onset of reperfusion by auto-transplantation is emerging not only as potential therapy of myocardial rescue, but as gateway to a deeper understanding of mitochondrial metabolism and function. In this chapter, we explore the mechanisms of mitochondrial dysfunction during ischemia and reperfusion, current developments in the methodology of mitochondrial transplantation, mechanisms of cardioprotection and their clinical implications.

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Acknowledgments 

This work was supported by: The Richard A. and Susan F. Smith Foundation, President’s Innovation Award, Boston Children’s Hospital, Michael B. Klein and Family, the Sidman Family Foundation, the Bulens/Capozzi Foundation, the Boston Children’s Hospital Anesthesia Foundation, the Kenneth C. Griffin Charitable Research Fund and the Boston Investment Council. This work in part was funded by NIH 5T32HL007734 fellowship to Dr. Shin.

Disclosures 

Dr. McCully, Dr. Cowan and Dr. del Nido have patents pending for the isolation and usage of mitochondria. There are no other conflicts of interest by any of the authors. The authors attest they had full freedom to explore the data, analyze the results independent from any sponsor and that they had sole authority to make the final decision to submit the material for publication.

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Authors and Affiliations

  1. Department of Cardiac Surgery, Boston Children’s Hospital, Boston, MA, USA

    Borami Shin MD

  2. Department of Anesthesiology, Division of Cardiac Anesthesia Research, Harvard Medical School, Boston Children’s Hospital, Boston, MA, USA

    Douglas B. Cowan PhD

  3. Division of Cardiovascular Critical Care, Harvard Medical School, Boston Children’s Hospital, Boston, MA, USA

    Sitaram M. Emani MD

  4. Department of Cardiac Surgery, William E. Ladd Professor of Child Surgery, Harvard Medical School, Boston Children’s Hospital, Boston, MA, USA

    Pedro J. del Nido MD

  5. Department of Cardiac Surgery, Harvard Medical School, Boston Children’s Hospital, Boston, USA

    James D. McCully PhD

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  1. Borami Shin MD
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  2. Douglas B. Cowan PhD
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  3. Sitaram M. Emani MD
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  4. Pedro J. del Nido MD
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  5. James D. McCully PhD
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Correspondence to James D. McCully PhD .

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  1. Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy

    Gaetano Santulli

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Shin, B., Cowan, D.B., Emani, S.M., del Nido, P.J., McCully, J.D. (2017). Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury. In: Santulli, G. (eds) Mitochondrial Dynamics in Cardiovascular Medicine. Advances in Experimental Medicine and Biology, vol 982. Springer, Cham. https://doi.org/10.1007/978-3-319-55330-6_31

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