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Mitochondrial Dynamics in Cardiovascular Medicine pp 521–528Cite as

Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 982))

Abstract

Mounting evidence indicates that mitochondria contain multiple phosphorylation substrates and that protein kinases translocate into mitochondria, suggesting that protein phosphorylation in this organelle could be fundamental for the regulation of its own function. Here we examine the mechanistic role of cellular kinases in the fine regulation of key mitochondrial activities, including mitochondrial quality control, fission/fusion processes, metabolism, and mitophagy.

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Acknowledgements

Dr. Gaetano Santulli, M.D., Ph.D. is supported by the National Institutes of Health (NIH, Grant NIDDK107895).

Author information

Authors and Affiliations

  1. Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy

    Daniela Sorriento, Antonella Fiordelisi & Bruno Trimarco

  2. Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy

    Jessica Gambardella, Michele Ciccarelli & Guido Iaccarino

  3. Columbia University Medical Center, New York, NY, USA

    Jessica Gambardella

  4. Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy

    Gaetano Santulli

  5. Columbia University Medical Center, New York Presbyterian Hospital—Manhattan, New York, NY, USA

    Gaetano Santulli

Authors
  1. Daniela Sorriento
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  2. Jessica Gambardella
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  3. Antonella Fiordelisi
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  4. Bruno Trimarco
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  5. Michele Ciccarelli
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  6. Guido Iaccarino
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  7. Gaetano Santulli
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Correspondence to Gaetano Santulli .

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Editors and Affiliations

  1. Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy

    Gaetano Santulli

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Sorriento, D. et al. (2017). Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness. In: Santulli, G. (eds) Mitochondrial Dynamics in Cardiovascular Medicine. Advances in Experimental Medicine and Biology, vol 982. Springer, Cham. https://doi.org/10.1007/978-3-319-55330-6_26

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