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Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders

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Mitochondrial Dynamics in Cardiovascular Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 982))

Abstract

Mitochondrial dynamics play a critical role in cellular responses and physiological process. However, their dysregulation leads to a functional degradation, which results in a diverse array of common disorders, including cardiovascular disease. In this background, the mitochondrial ubiquitin ligase has been attracting substantial research interest in recent years. Mitochondrial ubiquitin ligase is localized in the mitochondrial outer membrane, where it plays an essential role in the regulation of mitochondrial dynamics and apoptosis. In this chapter, we provide a comprehensive overview of the functions of mitochondrial ubiquitin ligases identified hitherto, with a special focus on cardiovascular disorders.

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Authors and Affiliations

  1. Institute of Translational Medicine, Qingdao University, 38 Dengzhou, Qingdao, People’s Republic of China

    Tao Yu, Yinfeng Zhang & Pei-feng Li

Authors
  1. Tao Yu
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  2. Yinfeng Zhang
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  3. Pei-feng Li
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Corresponding author

Correspondence to Pei-feng Li .

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Editors and Affiliations

  1. Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy

    Gaetano Santulli

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© 2017 Springer International Publishing AG

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Yu, T., Zhang, Y., Li, Pf. (2017). Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders. In: Santulli, G. (eds) Mitochondrial Dynamics in Cardiovascular Medicine. Advances in Experimental Medicine and Biology, vol 982. Springer, Cham. https://doi.org/10.1007/978-3-319-55330-6_17

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