Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model

  • Liangjie Yin
  • Lauren Vaught
  • Paul OkunieffEmail author
  • Katherine Casey-Sawicki
  • Sadasivan Vidyasagar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)


Nausea and diarrhea are common yet inconsistent side effects of abdominal and pelvic irradiation. Their frequency, chronicity, and severity vary greatly, and the reasons for inter-subject variability are unknown. We studied the potential for radiation-induced changes in amino acid absorption and mucosal barrier function to lead to gastrointestinal toxicity. We found profound and prolonged changes in the absorption and secretion of several electrolytes and nutrients, caused by changes in transporter function, after radiation doses as low as 1 to 3 Gy. After identifying absorbed and non-absorbed amino acids, we demonstrated the role of a beneficial amino acid drink to alleviate radiation-related gastrointestinal symptoms in a mouse model.


Radiation Nausea Gastrointestinal toxicity Pica model Amino acids 



This research was supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and Entrinsic Health Solutions (P0018160). Drs. Vidyasagar and Okunieff have shares in Entrinsic Health Solutions and hold scientific advisor positions within the company.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Liangjie Yin
    • 1
  • Lauren Vaught
    • 1
  • Paul Okunieff
    • 1
    Email author
  • Katherine Casey-Sawicki
    • 1
  • Sadasivan Vidyasagar
    • 1
  1. 1.Department of Radiation OncologyUniversity of Florida College of MedicineGainesvilleUSA

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