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Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization

  • Boris Epel
  • Matt Maggio
  • Charles Pelizzari
  • Howard J. HalpernEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

Modern standards for radiation treatment do not take into account tumor oxygenation for radiation treatment planning. Strong correlation between tumor oxygenation and radiation treatment success suggests that oxygen-guided radiation therapy (OGRT) may be a promising enhancement of cancer radiation treatment. We have developed an OGRT protocol for rodents. Electron paramagnetic resonance (EPR) imaging is used for recording oxygen maps with high spatial resolution and excellent accuracy better than 1 torr. Radiation is delivered with an animal intensity modulated radiation therapy (IMRT) XRAD225Cx micro-CT/ therapy system. The radiation plan is delivered in two steps. First, a uniform 15% tumor control dose (TCD15) is delivered to the whole tumor. In the second step, an additional booster dose amounting to the difference between TCD98 and TCD15 is delivered to radio-resistant, hypoxic tumor regions. Delivery of the booster dose is performed using a multiport conformal beam protocol. For radiation beam shaping we used individual radiation blocks 3D-printed from tungsten infused ABS polymer. Calculation of beam geometry and the production of blocks is performed next to the EPR imager, immediately after oxygen imaging. Preliminary results demonstrate the sub-millimeter precision of the radiation delivery and high dose accuracy. The efficacy of the radiation treatment is currently being tested on syngeneic FSa fibrosarcoma tumors grown in the legs of C3H mice.

Keywords

Electron paramagnetic resonance Oxygen imaging Radiation delivery Cancer treatment Image guided radiotherapy 

Notes

Acknowledgments

This study was supported by NIH grants P41 EB002034 and R01 CA98575.

References

  1. 1.
    Leibel SA, Fuks Z, Zelefsky MJ, Hunt M, Burman CM, Mageras GS, Chui CS, Jackson A, Amols HI, Ling CC (2003) Technological advances in external-beam radiation therapy for the treatment of localized prostate cancer. Semin Oncol 30:596–615CrossRefPubMedGoogle Scholar
  2. 2.
    Mundt A, Roeske J (2005) Intensity modulated radiation therapy. B.C.Decker, HamiltonGoogle Scholar
  3. 3.
    Vaupel P, Mayer A (2007) Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metast Rev 26:225–239CrossRefGoogle Scholar
  4. 4.
    Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88–91CrossRefPubMedGoogle Scholar
  5. 5.
    Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT (2009) Hypoxia and radiation therapy: past history, ongoing research, and future promise. Curr Mol Med 9:442–458CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509–4515PubMedGoogle Scholar
  7. 7.
    Elas M, Magwood JM, Butler B, Li C, Wardak R, Barth ED, Epel B, Rubinstein S, Pelizzari CA, Weichselbaum RR, Halpern HJ (2013) EPR oxygen images predict tumor control by a 50% tumor control radiation dose. Cancer Res 73:5328–5335CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Epel B, Bowman MK, Mailer C, Halpern HJ (2014) Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance. Magnet Reson Med 72:362–368CrossRefGoogle Scholar
  9. 9.
    Epel B, Halpern H (2013) Electron paramagnetic resonance oxygen imaging in vivo. Electron Paramag Res 23:180–208CrossRefGoogle Scholar
  10. 10.
    Epel B, Sundramoorthy SV, Mailer C, Halpern HJ (2008) A versatile high speed 250-MHz pulse imager for biomedical applications. Conc Magn Reson B 33B:163–176CrossRefGoogle Scholar
  11. 11.
    Haney CR, Fan X, Parasca AD, Karczmar GS, Halpern HJ, Pelizzari CA (2008) Immobilization using dental material casts facilitates accurate serial and multimodality small animal imaging. Conc Magn Reson B 33B:138–144CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Boris Epel
    • 1
  • Matt Maggio
    • 1
  • Charles Pelizzari
    • 1
  • Howard J. Halpern
    • 1
    Email author
  1. 1.Center for EPR Imaging In Vivo Physiology; Department of Radiation and Cellular OncologyUniversity of ChicagoChicagoUSA

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