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Relation Between Cognitive Function and Baseline Concentrations of Hemoglobin in Prefrontal Cortex of Elderly People Measured by Time-Resolved Near-Infrared Spectroscopy

  • Y. Murayama
  • Y. Sato
  • L. Hu
  • A. Brugnera
  • A. Compare
  • Kaoru SakataniEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

We evaluated relationship between cognitive function and cerebral blood oxygenation (CBO) of the prefrontal cortex (PFC) at rest in 113 adults (age 72.3 ± 12.0 years). We employed a two channel time-resolved near-infrared spectroscopy (TRS), which allows non-invasive measurements of baseline concentrations of oxyhemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb), total-hemoglobin (t-Hb) (μM) and oxygen saturation (SO2, %) of the bilateral PFC without any tasks. We examined cognitive functions using the Mini-Mental State Examination (MMSE) (range from 0 to 30) and the Touch M which evaluates working memory function semi-automatically on a touchscreen (range from 0 to 100); the mean MMSE and Touch M scores of all subjects were 24.8 ± 4.6 (mean ± SD; range 11–30) and 41.3 ± 22.1 (range 1–100), respectively. Employing Pearson's correlation analysis, we evaluated correlation between the TRS parameters and cognitive function. We found a significant positive correlation between the MMSE scores and SO2 (r = 0.24, p < 0.02). In addition, we observed significant positive correlations between Touch M scores and baseline concentrations of oxy-Hb (r = 0.26, p < 0.02), total-Hb (r = 0.23, p < 0.05), and SO2 (r = 0.23, p < 0.05). TRS allowed us to evaluate the relation between CBO in the PFC at rest and cognitive function.

Keywords

TRS NIRS Dementia Alzheimer’s disease Cognitive function 

Notes

Acknowledgments

This research was supported in part by the Strategic Research Foundation Grant-aided Project for Private Universities (S1411017) and a Grant-in-Aid for Exploratory Research (25560356) from the Ministry of Education, Culture, Sports, Sciences, and Technology of Japan. Furthermore, this research was supported through grants from Iing Co., Ltd. (Tokyo, Japan) and Southern Tohoku Hospital (Fukushima, Japan).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Y. Murayama
    • 1
    • 2
  • Y. Sato
    • 1
    • 2
  • L. Hu
    • 1
    • 2
  • A. Brugnera
    • 1
    • 2
  • A. Compare
    • 1
    • 2
  • Kaoru Sakatani
    • 1
    • 2
    Email author
  1. 1.NEWCAT Research Institute, Department of Electrical and Electronics Engineering, College of EngineeringKoriyamaJapan
  2. 2.Department of Human & Social ScienceUniversity of BergamoBergamoItaly

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