Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain
Imaging brain oxygenation is crucial for preventing brain lesions in preterm infants. Our aim is to build and validate a near-infrared optical tomography (NIROT) sensor for the head of neonates. This sensor, combined with an optoacoustic device, will enable quantitative monitoring of the structural and functional information of the brain. Since the head of preterm infants is small and fragile great care must be taken to produce a comfortable and compact device in which a sufficient number of light sources and detectors can be implemented. Here we demonstrate our first prototype. Heterogeneous silicone phantoms were produced to validate the prototype’s data acquisition, data processing, and image reconstruction. Reconstructed optical properties agree well with the target values. The mechanical performance of the new NIROT sensor prototype confirms its suitability for the clinical application.
KeywordsNear-infrared imaging Silicone sensor Reconstruction Silicone phantoms 3D print technology
This work was supported by the SwissTransMed project ONIRIUS, Swiss Cancer Research project KFS-3732-08-2015, KFSP Tumor Oxygenation and KFSP Molecular Imaging Network Zurich of the University Zurich, Swiss National Science Foundation (Grant number 139238 and 159490) and by the National Competence Center for Biomedical Imaging.
- 6.Hueber DM, Fantini S, Cerussi AE, et al (1999) New optical probe designs for absolute (self-calibrating) NIR tissue hemoglobin measurements. In: BiOS’99 international biomedical optics symposium. International Society for Optics and Photonics, pp 618–631Google Scholar