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Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain

  • Linda AhnenEmail author
  • Helene Stachel
  • Stefan Kleiser
  • Cornelia Hagmann
  • Jingjing Jiang
  • Alexander Kalyanov
  • Scott Lindner
  • Martin Wolf
  • Salvador Sanchez
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

Imaging brain oxygenation is crucial for preventing brain lesions in preterm infants. Our aim is to build and validate a near-infrared optical tomography (NIROT) sensor for the head of neonates. This sensor, combined with an optoacoustic device, will enable quantitative monitoring of the structural and functional information of the brain. Since the head of preterm infants is small and fragile great care must be taken to produce a comfortable and compact device in which a sufficient number of light sources and detectors can be implemented. Here we demonstrate our first prototype. Heterogeneous silicone phantoms were produced to validate the prototype’s data acquisition, data processing, and image reconstruction. Reconstructed optical properties agree well with the target values. The mechanical performance of the new NIROT sensor prototype confirms its suitability for the clinical application.

Keywords

Near-infrared imaging Silicone sensor Reconstruction Silicone phantoms 3D print technology 

Notes

Acknowledgments

This work was supported by the SwissTransMed project ONIRIUS, Swiss Cancer Research project KFS-3732-08-2015, KFSP Tumor Oxygenation and KFSP Molecular Imaging Network Zurich of the University Zurich, Swiss National Science Foundation (Grant number 139238 and 159490) and by the National Competence Center for Biomedical Imaging.

References

  1. 1.
    Khwaja O, Volpe JJ (2008) Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 93(2):F153–F161CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Beard P (2011) Biomedical photoacoustic imaging. Interface focus 1(4):602–631. doi: 10.1098/rsfs20110028 CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Hebden JC, Austin T (2007) Optical tomography of the neonatal brain. Eur Radiol 17(11):2926–2933CrossRefPubMedGoogle Scholar
  4. 4.
    Barbier A, Boivin A, Yoon W et al (2013) New reference curves for head circumference at birth, by gastational age. Pediatrics 131(4):e1158. doi: 10.1542/peds.2011-3846 CrossRefPubMedGoogle Scholar
  5. 5.
    Ahnen L, Wolf M, Hagmann C et al (2016) Near-infrared image reconstruction of newborns’ brains: robustness to perturbations of the source/detector location. In: Oxygen transport to tissue XXXVII. Springer, New York, pp 377–382CrossRefGoogle Scholar
  6. 6.
    Hueber DM, Fantini S, Cerussi AE, et al (1999) New optical probe designs for absolute (self-calibrating) NIR tissue hemoglobin measurements. In: BiOS’99 international biomedical optics symposium. International Society for Optics and Photonics, pp 618–631Google Scholar
  7. 7.
    Arri SJ, Muehlemann T, Biallas et al (2011) Precision of cerebral oxygenation and he-moglobin concentration measurements in neonates measured by near-infrared spectroscopy. J Biomed Opt 16(4):047005CrossRefPubMedGoogle Scholar
  8. 8.
    Jermyn M, Ghadyani H, Mastanduno MA et al (2013) Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography. J Biomed Opt 18(8):086007. doi: 10.1117/1.JBO.18.8.086007 CrossRefPubMedCentralGoogle Scholar
  9. 9.
    Dehghani H, Eames ME, Yalavarthy PK et al (2009) Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction. Commun Numer Methods Eng 25:711–732CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Linda Ahnen
    • 1
    Email author
  • Helene Stachel
    • 1
  • Stefan Kleiser
    • 1
  • Cornelia Hagmann
    • 1
  • Jingjing Jiang
    • 1
  • Alexander Kalyanov
    • 1
  • Scott Lindner
    • 1
  • Martin Wolf
    • 1
  • Salvador Sanchez
    • 1
  1. 1.Biomedical Optics Research LaboratoryUniversity Hospital ZurichZurichSwitzerland

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