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Relation Between EEG Activity and Brain Oxygenation in Preterm Neonates

  • Alexander CaicedoEmail author
  • Liesbeth Thewissen
  • Anne Smits
  • Gunnar Naulaers
  • Karel Allegaert
  • Sabine Van Huffel
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

This study investigates the relationship between brain oxygenation, assessed by means of near infrared spectroscopy (NIRS), and brain function, assessed by means of electroencephalography (EEG). Using NIRS signals measuring the regional cerebral oxygen saturation (rScO2) and computing the fractional tissue oxygen extraction (FTOE), we compared how these variables relate to different features extracted from the EEG, such as the inter-burst interval (IBI) duration and amplitude, the amplitude of the EEG, and the amplitude of the burst. A cohort of 22 neonates undergoing sedation by propofol was studied and a regression of the NIRS-derived values to the different EEG features was made. We found that higher values of FTOE were related to higher values of EEG amplitude. These results might be of used in the monitoring of proper brain function in neonates.

Keywords

Propofol EEG NIRS Flow-metabolic coupling 

Notes

Acknowledgments

Alexander Caicedo is a postdoctoral fellow of the research foundation Flanders (FWO). Bijzonder Onderzoeksfonds KU Leuven (BOF). This research was also supported by: Center of Excellence (CoE) #: PFV/10/002 (OPTEC). Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (FWO), project #: G.0427.10 N (Integrated EEG-fMRI), G.0108.11 (Compressed Sensing), G.0869.12 N (Tumor imaging), G.0A5513N (Deep brain stimulation). Agentschap voor Innovatie door Wetenschap en Technologie (IWT), project #: TBM 080658-MRI (EEG-fMRI), TBM 110697-NeoGuard. iMinds Medical Information Technologies. Dotatie-Strategisch basis onderzoek (SBO- 2015). ICON: NXT_Sleep. Belgian Federal Science Policy Office. IUAP #P7/19/ (DYSCO, `Dynamical systems, control and optimization’, 2012-2017). Belgian Foreign Affairs-Development Cooperation. VLIR UOS programs (2013-2019). EU: European Union’s Seventh Framework Programme (FP7/2007-2013): EU MC ITN TRANSACT 2012, #316679, ERASMUS EQR: Community service engineer, #539642-LLP-1-2013. Other EU: INTERREG IVB NWE programme #RECAP 209G. European Research Council: ERC Advanced Grant, #339804 BIOTENSORS This paper reflects only the authors’ views and the Union is not liable for any use that may be made of the contained information. The research activities are further facilitated by the agency for innovation by Science and Technology in Flanders (IWT) through the SAFEPEDRUG project (IWT/SBO 130033).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Alexander Caicedo
    • 1
    • 2
    Email author
  • Liesbeth Thewissen
    • 3
  • Anne Smits
    • 3
    • 4
  • Gunnar Naulaers
    • 3
  • Karel Allegaert
    • 3
  • Sabine Van Huffel
    • 1
    • 2
  1. 1.Department of Electrical EngineeringSTADIUS-ESAT, KU LeuvenLeuvenBelgium
  2. 2.imecLeuvenBelgium
  3. 3.Department of Development and RegenerationKU LeuvenLeuvenBelgium
  4. 4.Intensive Care and Department of SurgeryErasmus MC Sophia Children’s HospitalRotterdamThe Netherlands

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