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Inter-individual Differences in Exercise-Induced Spatial Working Memory Improvement: A Near-Infrared Spectroscopy Study

  • Yudai YamazakiEmail author
  • Daisuke Sato
  • Koya Yamashiro
  • Atsuhiro Tsubaki
  • Yui Yamaguchi
  • Nana Takehara
  • Atsuo Maruyama
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

Acute aerobic exercise at a mild intensity improves cognitive function. However, the response to exercise exhibits inter-individual differences, and the mechanisms underlying these differences remain unclear. The objective of this study was to determine potential factors in the brain that underlie differential responses to exercise in terms of cognitive improvement using functional near-infrared spectroscopy. Fourteen healthy subjects participated in these experiments. Participants performed a low intensity cycling exercise at 30% maximal oxygen uptake (VO2peak) for 10 min and performed a spatial memory task before and after exercising (5 and 30 min). The spatial memory task comprised two levels of difficulty (low: 1-dot EXERCISE, high: 3-dot EXERCISE). Cortical oxy-hemoglobin (O2Hb) levels were recorded using near-infrared spectroscopy during both the exercise and the spatial memory task phases. Regions of interests included the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), and frontopolar area (FPA). The participants were divided into two groups depending on whether they were responders (improved task reaction time) or non-responders (no improvement). Subsequently, we analyzed the group characteristics and differences in the change in O2Hb levels during exercise and spatial working memory tasks. Acute mild exercise significantly improved mean reaction times in the 1-dot memory task but not in the 3-dot task across the participants. In the 1-dot EXERCISE, 10 subjects were responders and four subjects were non-responders, whereas in the 3-dot EXERCISE, seven subjects were non-responders. In responders, during exercise, we found higher O2Hb levels in the right VLPFC response for the 1-dot memory task. Acute mild exercise caused inter-individual differences in spatial memory improvement, which were associated with changes in O2Hb activity in the prefrontal area during the exercise phase but not during the actual spatial memory task. Therefore, individuals who respond with higher reactivity to mild intensity exercise in the VLPFC might obtain larger spatial working memory improvements following exercise than non-responders.

Keywords

Aerobic exercise Low intensity Spatial working memory Inter-individual difference Functional near-infrared spectroscopy 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Yudai Yamazaki
    • 1
    Email author
  • Daisuke Sato
    • 1
  • Koya Yamashiro
    • 1
  • Atsuhiro Tsubaki
    • 1
  • Yui Yamaguchi
    • 2
  • Nana Takehara
    • 1
  • Atsuo Maruyama
    • 1
  1. 1.Institute for Human Movement and Medical SciencesNiigata University of Health and WelfareNiigataJapan
  2. 2.Analytical and Measuring Instruments DivisionShimadzu CorporationKyotoJapan

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