Abstract
Children with chronic kidney disease (CKD) are at high risk of developing mineral and bone disorders (MBD). CKD-MBD comprise altered calcium and phosphate homeostasis, abnormal synthesis and secretion of parathyroid hormone (PTH) and vitamin D and alterations in bone metabolism and function. The growing skeleton is particularly vulnerable; optimal control of bone and mineral homeostasis is essential to prevent debilitating skeletal complications, achieve adequate growth and preserve long-term cardiovascular health. Optimal control of bone and mineral metabolism remains one of the major challenges in the treatment of paediatric patients with CKD.
This chapter discusses CKD-MBD problems at different ages and stages of CKD. Currently used biochemical and radiological diagnostic tools are presented, and therapeutic algorithms based on recent paediatric guidelines are discussed.
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Shroff, R. (2017). Chronic Kidney Disease – Mineral and Bone Disorder. In: Warady, B., Schaefer, F., Alexander, S. (eds) Pediatric Dialysis Case Studies. Springer, Cham. https://doi.org/10.1007/978-3-319-55147-0_24
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DOI: https://doi.org/10.1007/978-3-319-55147-0_24
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