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Irreversible Electroporation in Clinical Practice pp 191–200Cite as

Irreversible Electroporation for Perihilar Cholangiocarcinoma (Klatskin Tumors)

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Abstract

The overall prognosis for patients with perihilar cholangiocarcinoma (PHC) is dismal. Resection of the tumor remains the only curative treatment, but only 10–20% of patients have resectable disease at the time of diagnosis [1]. The majority of patients present with locally advanced disease or lymph node metastases upon presentation or during exploratory laparotomy which makes resection not amenable. As the prognosis of patients with locally advanced PHC (LAPHC) or PHC with lymph node metastases in the palliative setting is significantly better compared to patients with organ metastases [2], ablative therapies may be of use for symptom palliation and potential survival benefit. Unfortunately, current ablative techniques for LAPHC are limited by serious side effects. These limitations may be overcome by irreversible electroporation (IRE), of which the safety and feasibility have been demonstrated in the presence of main bile ducts and large vascular structures [3–5].

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Authors and Affiliations

  1. Department of Experimental Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands

    Eva Roos, Robert-Jan Coelen & Thomas M. van Gulik

  2. Department of Interventional Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Laurien G. P. H. Vroomen

  3. Department of Surgery, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands

    Eran van Veldhuisen

  4. Department of Radiology and Nuclear Medicine, VU University Medical Center, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Martijn R. Meijerink

Authors
  1. Eva Roos
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  2. Laurien G. P. H. Vroomen
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  3. Eran van Veldhuisen
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  4. Robert-Jan Coelen
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  5. Thomas M. van Gulik
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  6. Martijn R. Meijerink
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Correspondence to Martijn R. Meijerink .

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Editors and Affiliations

  1. Department of Radiology and Nuclear Medicine, VU University Amsterdam, Amsterdam, The Netherlands

    Martijn R. Meijerink

  2. Department of Radiology and Nuclear Medicine, VU University Amsterdam, Amsterdam, Noord-Holland, The Netherlands

    Hester J. Scheffer

  3. Vascular and Interventional Radiology, Miami University Hospital and Clinics, Miami, Florida, USA

    Govindarajan Narayanan

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Roos, E., Vroomen, L.G.P.H., van Veldhuisen, E., Coelen, RJ., van Gulik, T.M., Meijerink, M.R. (2018). Irreversible Electroporation for Perihilar Cholangiocarcinoma (Klatskin Tumors). In: Meijerink, M., Scheffer, H., Narayanan, G. (eds) Irreversible Electroporation in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-55113-5_12

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  • DOI: https://doi.org/10.1007/978-3-319-55113-5_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55112-8

  • Online ISBN: 978-3-319-55113-5

  • eBook Packages: MedicineMedicine (R0)

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