Abstract
A promising branch of translational medicine is Regenerative Medicine (RegMed). RegMed aims to improve health and quality of life by restoring, maintaining or enhancing tissues and functions of organs. In order to achieve this, RegMed utilizes several approaches. Among these, cell-based therapy represents the central focus of RegMed. Several cellular types have been considered for the investigation and application of regenerative cell therapy in disease organs. and bone marrow (BM)-derived endothelial progenitor cells (BM EPCs) are emerging as potential candidates. Here, particular emphasis is given to the description of their biological features, for understanding their relevance and potential in this field, as well as the related limitations in this and in successive chapters.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abraham E, Marincola FM, Chen ZN, Wang XD (2012) Clinical and translationalmedicine: integrative and practical science. Clin Trans Med 1:1
Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815–1822
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T et al (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964–967
Atala A (2012) Tissue engineering of reproductive tissues and organs. Fertil Steril 98:21–29
Balistreri CR (2015) Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk determinants. Vascul Pharmacol 74:1–10. doi:10.1016/j.vph.2015.09.006
Balistreri CR, Buffa S, Pisano C, Lio D, Ruvolo G, Mazzesi G (2015) Are endothelial progenitor cells the real solution for cardiovascular diseases? Focus on controversies and perspectives. BioMed Research International, Egypt Article ID 835934; 1–18
Balistreri CR, Madonna R, Melino G, Caruso C (2016) The emerging role of Notch pathway in ageing: focus on the related mechanisms in age-related diseases. Ageing Res Rev 29:50–65. doi:10.1016/j.arr.2016.06.004
Boyle AJ, Schulman SP, Hare JM, Oettgen P (2006) Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair Ready for the Next Step. Circulation 114:339–352
Broxmeyer HE (2010) Cord blood hematopoietic stem cell transplantation. 2010 May 26. StemBook [Internet]. Harvard Stem Cell Institute, Cambridge; 2008. Available from http://www.ncbi.nlm.nih.gov/books/NBK44751/
Caliceti C, Nigro P, Rizzo P, Ferrari R (2014) ROS, Notch, and Wnt signaling pathways: crosstalk between three major regulators of cardiovascular biology. Biomed Res Int. 2014:318714. doi:10.1155/2014/318714
Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP (2004) Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 1(94):92–95
Duda DG, Cohen KS, Scadden DT, Jain RK (2007) A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat Protoc 2:805–810
Feyen DA, Gaetani R, Doevendans PA, Sluijter JP (2016) Stem cell-based therapy: Improving myocardial cell delivery. Advanced drug delivery reviews 106:104–115 pii:S0169-409X(16)30133–8
Gersh BJ, Simari RD, Behfar A, Terzic CM, Terzic A (2009) Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc 84:876–892. doi:10.1016/S0025-6196(11)60505-3
Ito H, Rovira II, Bloom ML, Takeda K, Ferrans VJ, Quyyumi AA, Finkel T (1999) Endothelial progenitor cells as putative targets for angiostatin. Cancer Res 59:5875–5877
Karcher JR, Hoffmann BR, Liu P, Liu Y, Liang M, Greene AS (2015) Genome-wide epigenetic and proteomic analysis reveals altered Notch signaling in EPC dysfunction. Physiological Rep 3(4):e12358. doi:10.14814/phy2.123 pii
Kwon SM, Alev C, Asahara T (2009) The role of notch signaling in endothelial progenitor cell biology. Trends Cardiovasc Med 19:170–173. doi:10.1016/j.tcm.2009.10.002
Li DW, Liu ZQ, Wei J, Liu Y, Hu LS (2012) Contribution of endothelial progenitor cells to neovascularization. Int J Mol Med 30:1000–1006. doi:10.3892/ijmm.2012.1108
Lindroos B, Suuronen R, Miettinen S (2011) The potential of adipose stem cells in regenerative medicine. Stem Cell Rev. 7:269–291. doi:10.1007/s12015-010-9193-7
Ma F, Morancho A, Montaner J, Rosell A (2015) Endothelial progenitor cells and revascularization following stroke. Brain research 1623:150–159. doi:10.1016/j.brainres.2015.02.010 pii: S0006-8993(15)00094-3
Mason C, Dunnill P (2008a) A brief definition of regenerative medicine. Regen Med. 3:1–5. doi:10.2217/17460751.3.1.1
Mason C, Dunnill P (2008b) The crucial linkage required between regenerative medicine bioprocessors and clinicians. Regen Med. 3:435–442. doi:10.2217/17460751.3.4.435
Medina RJ, O’Neill CL, Sweeney M, Guduric-Fuchs J, Gardiner TA, Simpson DA, Stitt AW (2010) Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med Genomics 3:18. doi:10.1186/1755-8794-3-18
Murray IR, West CC, Hardy WR, James AW, Park TS, Nguyen A, Tawonsawatruk T, Lazzari L, Soo C, Péault B (2014) Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci 71:1353–1374. doi:10.1007/s00018-013-1462-6
Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, Muskheli V, Pabon L, Reinecke H, Murry CE (2007) Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J. 21:1345–1357
Okano H, Nakamura M, Yoshida K, Okada Y, Tsuji O, Nori S, Ikeda E, Yamanaka S, Miura K (2013) Steps toward safe cell therapy using induced pluripotent stem cells. Circ Res 112:523–533
Pelosi E, Castelli G, Testa U (2014) Endothelial progenitors. Blood Cells Mol Dis 52:186–194. doi:10.1016/j.bcmd.2013.11.004
Pittenger MF, Martin BJ (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95:9–20
Pompilio G, Cannata A, Peccatori F, Bertolini F, Nascimbene A, Capogrossi MC, Biglioli P (2004) Autologous peripheral blood stem cell transplantation for myocardial regeneration: a novel strategy for cell collection and surgical injection. Ann Thorac Surg 78:1808–1812
Porada CD, Atala AJ, Almeida-Porada G (2015) The hematopoietic system in the context of regenerative medicine. Methods 99:30057–30058. doi:10.1016/j.ymeth.2015.08.015 pii: S1046–2023
Povsic TJ, Najjar SS, Prather K, Zhou J, Adams SD, Zavodni KL, Kelly F, Melton LG, Hasselblad V, Heitner JF, Raman SV, Barsness GW, Patel MR, Kim RJ, Lakatta EG, Harrington RA, Rao SV (2013) EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy. J Thromb Thrombolysis 36:375–383. doi:10.1007/s11239-013-0944-6
Qu K, Wang Z, Lin XL, Zhang K, He XL, Zhang H (2015) MicroRNAs: Key regulators of endothelial progenitor cell functions. Clin Chim Acta 448:65–73. doi:10.1016/j.cca.2015.06.017
Rajasekar P, O’Neill CL, Eeles L, Stitt AW, Medina RJ (2015) Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. J Diabetes Res. 2015:436879. doi:10.1155/2015/436879
Resch T, Pircher A, Kähler CM, Pratschke J, Hilbe W (2012) Endothelial progenitor cells: current issues on characterization and challenging clinical applications. Stem Cell Rev. 8:926–939. doi:10.1007/s12015-011-9332-9
Rouchi AH, Mahdavi-Mazdeh M (2015) Regenerative medicine in organ and tissue transplantation: shortly and practically achievable? Int J Organ Trans Med 6(3):93–98
Sherman W, Martens TP, Viles-Gonzalez JF, Siminiak T (2006) Catheter-based delivery of cells to the heart. Nat Clin Pract Cardiovasc Med. 3(Suppl 1):S57–S64
Sieveking DP, Buckle A, Celermajer DS, Ng MK (2008) Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay. J Am Coll Cardiol 51(6):660–668. doi:10.1016/j.jacc.2007.09.059
Stoltz JF, de Isla N, Li YP, Bensoussan D, Zhang L, Huselstein C et al (2015) Stem cells and regenerative medicine: myth or reality of the 21th century. Stem Cells Int. 2015:734731. doi:10.1155/2015/734731
Thomas ED, Epstein RB (1965) Bone marrow transplantation in acute leukemia. Cancer Res 25:1521–1524
Urbich C, Dimmeler S (2004) Endothelial progenitor cells functional characterization. Trends Cardiovasc Med 14:318–322
Van Craenenbroeck EM, Van Craenenbroeck AH, van Ierssel S, BruyndonckxL Hoymans VY, Vrints CJ et al (2013) Quantification of circulatingCD34+/KDR+/CD45dim endothelial progenitor cells: analytical considerations. Int J Cardiol 167:1688–1695. doi:10.1016/j.ijcard.2012.10.047
van Ierssel SH, Jorens PG, Van Craenenbroeck EM, Conraads VM (2014) The endothelium, a protagonist in the pathophysiology of critical illness: focus on cellular markers. Biomed Res Int. 2014:985813. doi:10.1155/2014/985813
Wang X (2012) A new vision of definition, commentary, and understanding in clinical and translational medicine. ClinTransl Med 1:5. doi:10.1186/2001-1326-1-5
Watt SM, Gullo F, van der Garde M, Markeson D, Camicia R, Khoo CP, Zwaginga JJ (2013) The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull 108:25–53. doi:10.1093/bmb/ldt031
Wojakowski W, Landmesser U, Bachowski R, Jadczyk T, Tendera M (2012) Mobilization of stem and progenitor cells in cardiovascular diseases. Leukemia 26:23–33. doi:10.1038/leu.2011.184
Acknowledgements
I gratefully thank Dr Crapanzano who contributed in preparing some figures for this chapter.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Balistreri, C.R. (2017). From Regenerative Medicine to Endothelial Progenitor Cells as Potential Candidates. In: Endothelial Progenitor Cells. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-319-55107-4_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-55107-4_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-55106-7
Online ISBN: 978-3-319-55107-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)