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nTMS in Pediatrics: Special Issues and Solutions

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Navigated Transcranial Magnetic Stimulation in Neurosurgery

Abstract

Neurosurgical treatment of pediatric patients harbors specific considerations. Neocortical resective surgery is unique in the challenges of operating in the proximity of eloquent cortex, and in some diseases, such as focal intractable epilepsy, an appreciable fraction of neocortical resections are destined to be in the pediatric population. Using nTMS for motor and language mapping is becoming increasingly valued in pediatric presurgical planning. The nTMS technique has demonstrable utility for obtaining the information needed for localization of motor and language function in children, with minimal associated health risks and very little difficulty on behalf of the operator.

 This chapter outlines the special considerations for nTMS in pediatric patients, including modifications to equipment setups, stimulation intensities, and potential influence of antiepileptic medications. It moreover outlines the differences of nTMS compared to other functional mapping techniques in the pediatric population and provides practical information on how to work with children of any age in order to obtain optimal mapping results.

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References

  • Bahn MM, et al. Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation. AJR. American journal of roentgenology 1997;169(2):575–79.

    Google Scholar 

  • Beers CA, Federico P. Functional MRI applications in epilepsy surgery. Can J Neurol Sci 2012;39(3):271–85.

    Google Scholar 

  • Berg AT, et al. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes a prospective cohort study. Neurology. 2012;79(13):1384–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Branco DM, et al. Functional MRI of memory in the hippocampus: Laterality indices may be more meaningful if calculated from whole voxel distributions. Neuroimage 2006;32(2):592–602.

    Google Scholar 

  • Clusmann H, et al. Analysis of different types of resection for pediatric patients with temporal lobe epilepsy. Neurosurgery. 2004;54(4):847–60.

    Article  PubMed  Google Scholar 

  • Dorfmüller G, et al. Outcome of surgery in children with focal cortical dysplasia younger than 5 years explored by stereo-electroencephalography. Childs Nerv Syst. 2014;30(11):1875–83.

    Article  PubMed  Google Scholar 

  • Duchowny MS. Surgery for intractable epilepsy: issues and outcome. Pediatrics. 1989;84(5):886–94.

    CAS  PubMed  Google Scholar 

  • Eyre JA, et al. Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology. 2001;57(9):1543–54.

    Article  CAS  PubMed  Google Scholar 

  • Garrett MC, Nader P, Linda ML. Use of language mapping to aid in resection of gliomas in eloquent brain regions. Neurosurgery clinics of North America 2012;23(3):497–506.

    Google Scholar 

  • Giulioni M, et al. Seizure outcome of epilepsy surgery in focal epilepsies associated with temporomesial glioneuronal tumors: lesionectomy compared with tailored resection: Clinical article. J Neurosurg. 2009;111(6):1275–82.

    Article  PubMed  Google Scholar 

  • Griessenauer CJ, Salam S, Hendrix P, et al. Hemispherectomy for treatment of refractory epilepsy in the pediatric age group: a systematic review. J Neurosurg Pediatr. 2015;15:34–44.

    Article  PubMed  Google Scholar 

  • Hertz-Pannier L, et al. Noninvasive assessment of language dominance in children and adolescents with functional MRI A preliminary study. Neurology. 1997;48(4):1003–12.

    Article  CAS  PubMed  Google Scholar 

  • Holmes GL. Intractable epilepsy in children. Epilepsia 1996;37(s3):14–27.

    Google Scholar 

  • Kaye HL, et al. Neurophysiological evidence of preserved connectivity in tuber tissue. Epilepsy Behav Case Rep. 2016.

    Google Scholar 

  • Kaye HL, Gersner R, Pascual-Leone A, Boes A, Peters JM, Rotenberg A. Motor mapping by transcranial magnetic stimulation reveals a pathologically preserved immature motor lateralization in patients with intractable focal epilepsy. In: American academy of neurology annual meeting. 2017.

    Google Scholar 

  • Koh TH, Eyre JA. Maturation of corticospinal tracts assessed by electromagnetic stimulation of the motor cortex. Arch Dis Child. 1988;63(11):1347–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwan A, Ng WH, Otsubo H, Ochi A, Snead OC III, Tamber MS, et al. Hemispherectomy for the control of intractable epilepsy in childhood: comparison of 2 surgical techniques in a single institution. Neurosurgery. 2010;67(2 Suppl Operative):429–36.

    PubMed  Google Scholar 

  • Lin K-L, Pascual-Leone A. Transcranial magnetic stimulation and its applications in children. Chang Gung Med J. 2002;25(7):424–36.

    PubMed  Google Scholar 

  • Loddenkemper T, Harold HM, and Gabriel M. Complications during the Wada test. Epilepsy & Behavior 2008;13(3):551–53.

    Google Scholar 

  • Loring DW, Meador KJ, Lee GP, King DW. Amobarbital effects and lateralized brain function: the Wada test. New York: Springer-Verlag; 1992.

    Book  Google Scholar 

  • Loring DW, Meador KJ, Lee GP, et al. Wada memory performance predicts seizure outcome following anterior temporal lobectomy. Neurology. 1994;44:2322–4.

    Article  CAS  PubMed  Google Scholar 

  • Macedoni-Lukšič M, Jereb B, Todorovski L. Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. Pediatr Hematol Oncol. 2003;20(2):89–101.

    Article  PubMed  Google Scholar 

  • Paulus W, et al. State of the art: pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation. Brain stimulation 2008;1(3):151–63.

    Google Scholar 

  • Perry MS, Duchowny M. Surgical management of intractable childhood epilepsy: curative and palliative procedures. Semin Pediatr Neurol. 2011;18(3):195–202.

    Article  PubMed  Google Scholar 

  • Pohlmann-Eden B, et al. The first seizure and its management in adults and children. BMJ. 2006;332(7537):339.

    Article  PubMed  PubMed Central  Google Scholar 

  • Price CJ, Crinion J, Friston KJ. Design and analysis of fMRI studies with neurologically impaired patients. J Magn Reson Imaging. 2006;23(6):816–26.

    Article  PubMed  Google Scholar 

  • Saneto RP, Elaine W. Surgically treatable epilepsy syndromes in infancy and childhood. Epilepsy Surgery: Principles and Controversies. CRC Press, 2005;121–41.

    Google Scholar 

  • Souweidane MM, et al. Brain mapping in sedated infants and young children with passive-functional magnetic resonance imaging. Pediatr Neurosurg. 1999;30(2):86–92.

    Article  CAS  PubMed  Google Scholar 

  • Spencer DC, Morrell MJ, Risinger MW. The role of the intracarotid amobarbital procedure in evaluation of patients for epilepsy surgery. Epilepsia. 2000;41(3):320–5.

    Article  CAS  PubMed  Google Scholar 

  • Sperling MR, Saykin AJ, Glosser G, et al. Predictors of outcome after anterior temporal lobectomy: the intracarotid amobarbital test. Neurology. 1994;44:2325–30.

    Article  CAS  PubMed  Google Scholar 

  • Szaflarski JP, et al. Practice guideline summary: use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017;88(4):395–402.

    Article  PubMed  Google Scholar 

  • Weiner HL, et al. Epilepsy surgery for children with tuberous sclerosis complex. J Child Neurol. 2004;19(9):687–9.

    PubMed  Google Scholar 

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Correspondence to Alexander Rotenberg M.D., Ph.D. .

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Kaye, H.L., Rotenberg, A. (2017). nTMS in Pediatrics: Special Issues and Solutions. In: M. Krieg, S. (eds) Navigated Transcranial Magnetic Stimulation in Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-54918-7_12

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  • DOI: https://doi.org/10.1007/978-3-319-54918-7_12

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