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Progress for Antiviral Development in Latin America

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Human Virology in Latin America

Abstract

This chapter summarizes the main contributions for antiviral development from scientists in Latin America in the last decade. Antiviral research in this region has been mainly focused on the search for alternative therapeutic agents for herpes simplex virus infections and the development of antiviral strategies to handle neglected viral diseases that represent a serious threat for local public health. The antiviral potential of natural extracts and compounds isolated from a vast diversity of plants, algae, and other natural sources has also been explored. Similarly, the study of the efficacy and mode of action of a variety of synthetic compounds reveals the ongoing progress for antiviral research in the region. In addition, approaches based on host factors as antiviral targets and the use of bioinformatics methods that allow structure-based design of viral inhibitors have strongly emerged during the last years as powerful tools used by Latin-American researchers for the development of novel antiviral strategies.

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References

  1. Abrantes JL, Barbosa J, Cavalcanti D et al (2010) The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle. Planta Med 76:339–344

    Article  CAS  PubMed  Google Scholar 

  2. Acosta EG, Bruttomesso AC, Bisceglia J et al (2008) Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junín virus replication in vitro. Virus Res 135(2):203–212

    Article  CAS  PubMed  Google Scholar 

  3. Acosta EG, Castilla V, Damonte EB (2009) Alternative infectious entry pathways for dengue virus serotypes into mammalian cells. Cell Microbiol 11:1533–1549

    Article  CAS  PubMed  Google Scholar 

  4. Acosta EG, Castilla V, Damonte EB (2012) Differential requirements in endocytic trafficking for dengue virus penetration. PLoS One 7:e44835

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Acosta EG, Piccini LE, Talarico LB et al (2014) Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells. Virus Res 184:39–43

    Article  CAS  PubMed  Google Scholar 

  6. Albarnaz JD, De Oliveira LC, Torres AA et al (2014) MEK/ERK activation plays a decisive role in yellow fever virus replication: implication as an antiviral therapeutic target. Antiviral Res 111:82–92

    Article  CAS  PubMed  Google Scholar 

  7. Alché LE, Barquero AA, Sanjuan NA, Coto CE (2002) An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains herpes simplex virus type 1 propagation. Phytother Res 16(4):348–352

    Article  PubMed  CAS  Google Scholar 

  8. Allonso D, Andrade IS, Conde JN et al (2015) Dengue virus NS1 protein modulates cellular energy metabolism by increasing glyceraldehyde-3-phosphate dehydrogenase activity. J Virol 89(23):11871–11883

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Alvarez AL, del Barrio G, Kourí V et al (2009) In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis. Phytomedicine 16(10):960–966

    Article  CAS  PubMed  Google Scholar 

  10. Argenta DF, Silva IT, Bassani VL et al (2015) Antiherpes evaluation of soybean isoflavonoids. Arch Virol 160(9):2335–2342

    Article  CAS  PubMed  Google Scholar 

  11. Artuso MC, Ellenberg PC, Scolaro LA et al (2009) Inhibition of Junín virus replication by small interfering RNAs. Antiviral Res 84:31–37

    Article  CAS  PubMed  Google Scholar 

  12. Assunção-Miranda I, Cruz-Oliveira C, Neris RL et al (2016) Inactivation of dengue and yellow fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX. J Appl Microbiol 120(3):790–804

    Article  PubMed  CAS  Google Scholar 

  13. Avila L, Perez M, Sanchez-Duffhues G et al (2010) Effects of diterpenes from latex of Euphorbia lactea and Euphorbia laurifolia on human immunodeficiency virus type 1 reactivation. Phytochemistry 71(2-3):243–248

    Article  CAS  PubMed  Google Scholar 

  14. Barquero AA, Michelini FM, Alché LE (2006) 1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-kappaB modulating properties. Biochem Biophys Res Commun 344(3):955–962

    Article  CAS  PubMed  Google Scholar 

  15. Bernardino AM, Azevedo AR, Pinheiro LC et al (2012) Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines. Org Med Chem Lett 2(1):3

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Bertol JW, Rigotto C, de Pádua RM et al (2011) Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Res 92(1):73–80

    Article  CAS  PubMed  Google Scholar 

  17. Betancur-Galvis LA, Morales GE, Forero JE, Roldan J (2002) Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus. Mem Inst Oswaldo Cruz 97(4):541–546

    Article  CAS  PubMed  Google Scholar 

  18. Bettega JM, Teixeira H, Bassani VL et al (2004) Evaluation of the antiherpetic activity of standardized extracts of Achyrocline satureioides. Phytother Res 18(10):819–823

    Article  CAS  PubMed  Google Scholar 

  19. Bidone J, Argenta DF, Kratz J et al (2015) Antiherpes activity and skin/mucosa distribution of flavonoids from Achyrocline satureioides extract incorporated into topical nanoemulsions. Biomed Res Int 2015:238010

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Boechat Fda C, Sacramento CQ, Cunha AC et al (2015) 1,2,3-Triazolyl-4-oxoquinolines: a feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza A and B viruses. Bioorg Med Chem 23(24):7777–7784

    Article  PubMed  CAS  Google Scholar 

  21. Borges MC, Castro LA, Fonseca BA (2013) Chloroquine use improves dengue-related symptoms. Mem Inst Oswaldo Cruz 108(5):596–599

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Brunetti JE, Scolaro LA, Castilla V (2015) The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a host factor required for dengue virus and Junín virus multiplication. Virus Res 203:84–91

    Article  CAS  PubMed  Google Scholar 

  23. Bueno CA, Alché LE, Barquero AA (2010) 1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity. Biochem Biophys Res Commun 393(1):32–37

    Article  CAS  PubMed  Google Scholar 

  24. Bueno CA, Michelini FM, Pertino MW et al (2015) Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway. Med Microbiol Immunol 204(5):575–584

    Article  CAS  PubMed  Google Scholar 

  25. Cabarcas-Montalvo M, Maldonado-Rojas W, Montes-Grajales D et al (2016) Discovery of antiviral molecules for dengue: in silico search and biological evaluation. Eur J Med Chem 110:87–97

    Article  CAS  PubMed  Google Scholar 

  26. Cáceres PJ, Carlucci MJ, Damonte EB et al (2000) Carrageenans from chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity. Phytochemistry 53:81–86

    Article  PubMed  Google Scholar 

  27. Cardozo FT, Camelini CM, Mascarello A et al (2011) Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia. Antiviral Res 92:108–114

    Article  CAS  PubMed  Google Scholar 

  28. Cardozo FT, Larsen IV, Carballo EV et al (2013) In vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide. Antimicrob Agents Chemother 57:2541–2549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Carlucci MJ, Ciancia M, Matulewicz MC et al (1999) Antiherpetic activity and mode of action of natural carrageenans of diverse structural types. Antiviral Res 43:93–102

    Article  CAS  PubMed  Google Scholar 

  30. Carlucci MJ, Scolaro LA, Noseda MD et al (2004) Protective effect of a natural carrageenan on genital herpes simplex virus infection in mice. Antiviral Res 64:137–141

    Article  CAS  PubMed  Google Scholar 

  31. Carmo AC, Yamasaki LH, Figueiredo CA et al (2015) Discovery of a new antiviral protein isolated from Lonomia obliqua analysed by bioinformatics and real-time approaches. Cytotechnology 67:1011–1022

    Article  CAS  PubMed  Google Scholar 

  32. Carneiro B, Braga AC, Batista MN et al (2015) Evaluation of canonical siRNA and Dicer substrate RNA for inhibition of hepatitis C virus genome replication: a comparative study. PLoS One 10(2):e0117742

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  33. Carvalho CA, Sousa IP Jr, Silva JL et al (2014) Inhibition of Mayaro virus infection by bovine lactoferrin. Virology 452-453:297–302

    Article  CAS  PubMed  Google Scholar 

  34. Cassolato JEF, Noseda MD, Pujol CA et al (2008) Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma. Carbohydr Res 343:3085–3095

    Article  CAS  PubMed  Google Scholar 

  35. Castilla V, Ramírez J, Coto CE (2010) Plant and animal steroids a new hope to search for antiviral agents. Curr Med Chem 17(18):1858–1873

    Article  CAS  PubMed  Google Scholar 

  36. Castilla V, Piccini LE, Damonte EB (2015) Dengue virus entry and trafficking: perspectives as antiviral target for prevention and therapy. Future Virol 10:625–645

    Article  CAS  Google Scholar 

  37. Ceballos-Olvera I, Chávez-Salinas S, Medina F et al (2010) JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology 396:30–36

    Article  CAS  PubMed  Google Scholar 

  38. Cecilio AB, Caldas S, Oliveira RA et al (2013) Molecular characterization of Lys49 and Asp49 phospholipases A2 from snake venom and their antiviral activities against dengue virus. Toxins (Basel) 5:1780–1798

    Article  CAS  Google Scholar 

  39. Chaves Valadão AL, Abreu CM, Dias JZ et al (2015) Natural plant alkaloid (emetine) inhibits HIV-1 replication by interfering with reverse transcriptase activity. Molecules 20(6):11474–11489

    Article  PubMed  CAS  Google Scholar 

  40. Cirne-Santos CC, Souza TM, Teixeira VL et al (2008) The dolabellane diterpene dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme. Antiviral Res 77:64–71

    Article  CAS  PubMed  Google Scholar 

  41. Corrêa NB, Penna FJ, Lima FM et al (2011) Treatment of acute diarrhea with Saccharomyces boulardii in infants. J Pediatr Gastroenterol Nutr 53:497–501

    PubMed  Google Scholar 

  42. Cosenza VA, Navarro DA, Pujol CA et al (2015) Partial and total C-6 oxidation of gelling carrageenans. Modulation of the antiviral activity with the anionic character. Carbohydr Polym 128:199–206

    Article  CAS  PubMed  Google Scholar 

  43. da Costa EC, Amorim R, da Silva FC et al (2013) Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication. PLoS One 8(12):e82504

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. da Cunha EF, Matos KS, Ramalho TC (2013) QSAR and docking studies of HCV NS3 serine protease inhibitors. Med Chem 9(6):774–805

    Article  PubMed  CAS  Google Scholar 

  45. da Silva AS, Raposo JV, Pereira TC et al (2016) Effects of RNA interference therapy against herpes simplex virus type 1 encephalitis. Antivir Ther 21(3):225–235

    Google Scholar 

  46. Dávola ME, Alonso F, Cabrera GM et al (2012) Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins. Biochem Biophys Res Commun 427(1):107–112

    Article  PubMed  CAS  Google Scholar 

  47. Dávola ME, Mazaira GI, Galigniana MD et al (2015) Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of herpes simplex virus type 1. Antiviral Res 122:55–63

    Article  PubMed  CAS  Google Scholar 

  48. de Almeida H, Bastos IM, Ribeiro BM (2013) New binding site conformations of the dengue virus NS3 protease accessed by molecular dynamics simulation. PLoS One 8(8):e72402

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  49. de Godoi AM, Faccin-Galhardi LC, Lopes N et al (2015) Characterization and antiherpetic activity of native and chemically sulfated polysaccharide from Adenanthera pavonina. Curr Pharm Biotechnol 16(11):1024–1031

    Article  PubMed  CAS  Google Scholar 

  50. de Souza LM, Sassaki GL, Romanos MT et al (2012) Structural characterization and anti-HSV-1 and HSV-2 activity of glycolipids from the marine algae Osmundaria obtusiloba isolated from Southeastern Brazilian coast. Mar Drugs 10:918–931

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. dos Santos AE, Kuster RM, Yamamoto KA et al (2014) Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity. Parasit Vectors 7:130

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  52. Duarte MER, Noseda DG, Noseda MD et al (2001) Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro. Phytomedicine 8:53–58

    Article  CAS  PubMed  Google Scholar 

  53. Duarte MER, Cauduro JP, Noseda MD et al (2004) The structure of the agaran sulfate from Acantophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. Carbohydr Res 339:335–347

    Article  CAS  PubMed  Google Scholar 

  54. Espada SF, Faccin-Galhardi LC, Rincao VP et al (2015) Antiviral activity of Trichilia catigua bark extracts for herpesvirus and poliovirus. Curr Pharm Biotechnol 16(8):724–732

    Article  CAS  PubMed  Google Scholar 

  55. Farias KJ, Machado PR, de Almeida RF Jr et al (2014) Chloroquine interferes with dengue-2 virus replication in U937 cells. Microbiol Immunol 58(6):318–326

    Article  CAS  PubMed  Google Scholar 

  56. Farias KJ, Machado PR, Muniz JA et al (2015) Antiviral activity of chloroquine against dengue virus type 2 replication in Aotus monkeys. Viral Immunol 28(3):161–169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Feldman SC, Reynaldi S, Stortz CA et al (1999) Antiviral properties of fucoidan fractions from Leathessia difformis. Phytomedicine 6:335–340

    Article  CAS  PubMed  Google Scholar 

  58. Fernández Romero JA, Del Barrio AG, Romeu Alvarez B et al (2003) In vitro antiviral activity of Phyllanthus orbicularis extracts against herpes simplex virus type 1. Phytother Res 17(8):980–982

    Article  PubMed  Google Scholar 

  59. Figueiredo ML, Figueiredo MT (2014) Emerging alphaviruses in the Americas: Chikungunya and Mayaro. Rev Soc Bras Med Trop 47:677–683

    Article  PubMed  Google Scholar 

  60. García CC, Talarico LB, Almeida NV et al (2003) Virucidal activity of essential oils from aromatic plants of San Luis, Argentina. Phytother Res 17(9):1073–1075

    Article  PubMed  CAS  Google Scholar 

  61. García CC, Djavani M, Topisirovic I et al (2006) Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds. J Gen Virol 87(Pt 5):1217–1228

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  62. García C, Ellenberg P, Artuso M et al (2009) Characterization of Junín virus particles inactivated by a zinc finger-reactive compound. Virus Res 143(1):106–113

    Article  PubMed  CAS  Google Scholar 

  63. García CC, Topisirovic I, Djavani M et al (2010) An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein. Biochem Biophys Res Commun 393(4):625–630

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  64. García CC, Sepúlveda CS, Damonte EB (2011) Novel therapeutic targets for arenavirus hemorrhagic fevers. Future Virol 6:27–44

    Article  Google Scholar 

  65. Giovannoni F, Damonte EB, García CC (2015) Cellular promyelocytic leukemia p protein is an important dengue virus restriction factor. PLoS One 10(5):e0125690

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  66. Gómez LA, Stashenko E, Ocazionez RE (2013) Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus. Nat Prod Commun 8(2):249–252

    PubMed  Google Scholar 

  67. Govea-Salas M, Rivas-Estilla AM, Rodríguez-Herrera R et al (2016) Gallic acid decreases hepatitis C virus expression through its antioxidant capacity. Exp Ther Med 11(2):619–624

    CAS  PubMed  Google Scholar 

  68. Grandy G, Medina M, Soria R et al (2010) Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children. BMC Infect Dis 10:253

    Article  PubMed  PubMed Central  Google Scholar 

  69. Greco KN, Mendonça RM, Moraes RH et al (2009) Antiviral activity of the hemolymph of Lonomia obliqua (Lepidoptera: Saturniidae). Antiviral Res 84:84–90

    Article  CAS  PubMed  Google Scholar 

  70. Guimarães TR, Quiroz CG, Borges CR et al (2013) Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae). Mar Drugs 11:4176–4192

    Article  CAS  Google Scholar 

  71. Guimarães AP, de Souza FR, Oliveira AA et al (2014) Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox. Eur J Med Chem 91:72–90

    Article  PubMed  CAS  Google Scholar 

  72. Guzmán MG, Harris E (2015) Dengue. Lancet 385:453–465

    Article  PubMed  Google Scholar 

  73. Haddad R, Kashima S, Rodrigues ES et al (2011) Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cells. J Virol Methods 173(1):92–98

    Article  CAS  PubMed  Google Scholar 

  74. Herrero Uribe L, Chaves Olarte E, Tamayo Castillo G (2004) In vitro antiviral activity of Chamaecrista nictitans (Fabaceae) against herpes simplex virus: biological characterization of mechanisms of action. Rev Biol Trop 52(3):807–816

    PubMed  Google Scholar 

  75. Iglesias NG, Mondotte JA, Byk LA et al (2015) Dengue virus uses a non-canonical function of the host GBF1-Arf-COPI system for capsid protein accumulation on lipid droplets. Traffic 16:962–977

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Jardim AC, Igloi Z, Shimizu JF et al (2015) Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro. Antiviral Res 115:39–47

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Linero FN, Scolaro LA (2009) Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro. Virus Res 145:166–170

    Article  CAS  PubMed  Google Scholar 

  78. Linero FN, Sepúlveda CS, Giovannoni F et al (2012) Host cell factors as antiviral targets in arenavirus infection. Viruses 4:1569–1591

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. López-Martínez R, Ramírez-Salinas GL, Correa-Basurto J et al (2013) Inhibition of influenza A virus infection in vitro by peptides designed in silico. PLoS One 8(10):e76876

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Lucero BD, Gomes CR, Frugulhetti IC et al (2006) Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogues. Bioorg Med Chem Lett 16(4):1010–1013

    Article  CAS  PubMed  Google Scholar 

  81. Lückemeyer DD, Müller VD, Moritz MI et al (2012) Effects of Ilex paraguariensis A. St. Hil. (yerba mate) on herpes simplex virus types 1 and 2 replication. Phytother Res 26(4):535–540

    Google Scholar 

  82. Maeto CA, Knott ME, Linero FN et al (2011) Differential effect of acute and persistent Junín virus infections on the nucleo-cytoplasmic trafficking and expression of heterogeneous nuclear ribonucleoproteins type A and B. J Gen Virol 92:2181–2190

    Article  CAS  PubMed  Google Scholar 

  83. Márquez-Escobar VA, Tirado-Mendoza R, Noyola DE et al (2015) HRA2pl peptide: a fusion inhibitor for human metapneumovirus produced in tobacco plants by transient transformation. Planta (Berl) 242(1):69–76

    Article  CAS  Google Scholar 

  84. Martínez MG, Prado Acosta M, Candurra NA, Ruzal SM (2012) S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection. Biochem Biophys Res Commun 422:590–595

    Article  PubMed  CAS  Google Scholar 

  85. Martínez-Gutierrez M, Castellanos JE, Gallego-Gómez JC (2011) Statins reduce dengue virus production via decreased virion assembly. Intervirol 54:202–216

    Article  CAS  Google Scholar 

  86. Mateu CG, Recalde MP, Artuso MC et al (2011) Emergence of herpes simplex virus-1 syncytial variants with altered virulence for mice after selection with a natural carrageenan. Sex Transm Dis 38:555–561

    PubMed  Google Scholar 

  87. Matsuhiro B, Conte AF, Damonte EB et al (2005) Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta). Carbohydr Res 340:2392–2402

    Article  CAS  PubMed  Google Scholar 

  88. Mazzucco MB, Talarico LE, Vatansever S et al (2015) Antiviral activity of an N-allyl acridone against dengue virus. J Biomed Sci 22:29

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  89. Mello JF, Botelho N, Souza AM et al (2015) Computational studies of benzoxazinone derivatives as antiviral agents against herpesvirus type 1 protease. Molecules 20(6):10689–10704

    Article  PubMed  CAS  Google Scholar 

  90. Mendes GS, Soares AR, Sigiliano L et al (2011) In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales). Molecules 16:8437–8450

    Article  CAS  PubMed  Google Scholar 

  91. Mendes GS, Duarte ME, Colodi FG et al (2014) Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis. Carbohydr Polym 101:313–323

    Article  CAS  PubMed  Google Scholar 

  92. Meneses R, Ocazionez RE, Martínez JR, Stashenko EE (2009) Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro. Ann Clin Microbiol Antimicrob 8:8

    Article  PubMed  PubMed Central  Google Scholar 

  93. Miceli LA, Teixeira VL, Castro HC et al (2013) Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase. Mar Drugs 11:4127–4143

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  94. Michelini FM, Berra A, Alché LE (2008) The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice. J Steroid Biochem Mol Biol 108(1-2):164–170

    Article  CAS  PubMed  Google Scholar 

  95. Michelini FM, Zorrilla P, Robello C et al (2013) Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog. Bioorg Med Chem 21(2):560–568

    Article  CAS  PubMed  Google Scholar 

  96. Muller VD, Soares RO, dos Santos NN Jr et al (2014) Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope. PLoS One 9:e112351

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  97. Olaya Galán NN, Ulloa Rubiano JC, Velez Reyes FA et al (2016) In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production. J Appl Microbiol 120:1041–1051

    Article  PubMed  CAS  Google Scholar 

  98. Ono L, Wollinger W, Rocco I et al (2003) In vitro and in vivo antiviral properties of sulfated galactomannans against yellow fever virus (BeH111 strain) and dengue 1 virus (Hawaii strain). Antiviral Res 60(3):201–208

    Article  CAS  PubMed  Google Scholar 

  99. Ortega-Berlanga B, Musiychuk K, Shoji Y et al (2016) Engineering and expression of a RhoA peptide against respiratory syncytial virus infection in plants. Planta (Berl) 243(2):451–458

    Article  CAS  Google Scholar 

  100. Pacca CC, Severino AS, Mondini A et al (2009) RNA interference inhibits yellow fever virus replication in vitro and in vivo. Virus Genes 38(2):224–231

    Article  CAS  PubMed  Google Scholar 

  101. Pardo-Vargas A, de Barcelos OI, Stephens PR et al (2014) Dolabelladienols A-C, new diterpenes isolated from Brazilian brown alga Dictyota pfaffii. Mar Drugs 12:4247–4259

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  102. Pereira AC, Soares-Martins JA, Leite FG et al (2012) SP600125 inhibits orthopoxviruses replication in a JNK1/2-independent manner: Implication as a potential antipoxviral. Antiviral Res 93(1):69–77

    Article  CAS  PubMed  Google Scholar 

  103. Pereira HS, Leão-Ferreira LR, Moussatché N et al (2004) Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1). Antiviral Res 64:69–76

    CAS  PubMed  Google Scholar 

  104. Petrera E, Coto CE (2009) Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection. Phytother Res 23(12):1771–1777

    Article  CAS  PubMed  Google Scholar 

  105. Petrera E, Coto CE (2014a) Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2. Phytother Res 28(1):104–109

    Article  CAS  PubMed  Google Scholar 

  106. Petrera E, Níttolo AG, Alché LE (2014b) Antiviral action of synthetic stigmasterol derivatives on herpes simplex virus replication in nervous cells in vitro. Biomed Res Int 2014:947560

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  107. Piccini LE, Castilla V, Damonte EB (2015) Dengue-3 virus entry into Vero cells: role of clathrin-mediated endocytosis in the outcome of infection. PLoS One 10:e1140824

    Article  CAS  Google Scholar 

  108. Piccirillo E, Merget B, Sotriffer CA et al (2016) Conformational flexibility of DENV NS2B/NS3pro: from the inhibitor effect to the serotype influence. J Comput Aided Mol Des 30:251

    Google Scholar 

  109. Pires de Mello CP, Sardoux NS, Terra L et al (2016) Aminomethyl naphthoquinones and HSV-1: in vitro and in silico evaluations of potential antivirals. Antivir Ther. 21(6):507–515

    Google Scholar 

  110. Piret J, Boivin G (2011) Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence and management. Antimicrob Agents Chemother 55:459–472

    Article  CAS  PubMed  Google Scholar 

  111. Plouguerné E, de Souza LM, Sassaki GL et al (2013) Antiviral sulfoquinovosyldiacylglycerols (SQDGs) from the Brazilian brown seaweed Sargassum vulgare. Mar Drugs 11:4628–4640

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  112. Ponce NMA, Pujol CA, Damonte EB et al (2003) Fucoidans from the brown seaweed Adenocystis utricularis: extraction methods, antiviral activity and structural studies. Carbohydr Res 338:153–165

    Article  CAS  PubMed  Google Scholar 

  113. Puerta-Guardo H, Mosso C, Medina F et al (2010) Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains. J Gen Virol 91:394–403

    Article  CAS  PubMed  Google Scholar 

  114. Puerta-Guardo H, Medina F, De la Cruz Hernández SI et al (2012) The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res 94(1):57–61

    Article  CAS  PubMed  Google Scholar 

  115. Pujol CA, Estévez JM, Carlucci MJ et al (2002) Novel dl-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. Antivir Chem Chemother 13:83–89

    Article  CAS  PubMed  Google Scholar 

  116. Quintana VM, Torres NI, Wachsman MB et al (2014) Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin. J Appl Microbiol 117:1253–1259

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Ríos-Ibarra C, Lozano-Sepúlveda S, Muñoz-Espinosa L et al (2014) Downregulation of inducible nitric oxide synthase (iNOS) expression is implicated in the antiviral activity of acetylsalicylic acid in HCV-expressing cells. Arch Virol 159(12):3321–3328

    Article  PubMed  CAS  Google Scholar 

  118. Rodríguez ME, Brunetti JE, Wachsman MB et al (2014) Raf/MEK/ERK pathway activation is required for Junín virus replication. J Gen Virol 95:799–805

    Article  PubMed  CAS  Google Scholar 

  119. Rodriguez MC, Merino EC, Pujol CA et al (2005) Galactans from cystocarpic plants of the red seaweed Callophyllis variegata (Kallymeniaceae, Gigartinales). Carbohydr Res 340:2742–2751

    Article  CAS  PubMed  Google Scholar 

  120. Romanos MT, Andrada-Serpa MJ, Mourão PA et al (2002) A sulphated fucan from the Laminaria abyssalis inhibits the human T cell lymphotropic virus type 1-induced syncytium formation in HeLa cells. Antivir Chem Chemother 13:219–221

    Article  CAS  PubMed  Google Scholar 

  121. Romanutti C, Bruttomesso AC, Castilla V et al (2010) Anti-adenovirus activity of epiandrosterone and dehydroepiandrosterone derivatives. Chemotherapy 56(2):158–165

    Article  CAS  PubMed  Google Scholar 

  122. Ruffa MJ, Wagner ML, Suriano M et al (2004) Inhibitory effect of medicinal herbs against RNA and DNA viruses. Antivir Chem Chemother 15(3):153–159

    Article  CAS  PubMed  Google Scholar 

  123. Sacramento CQ, Marttorelli A, Fintelman-Rodrigues N et al (2015) Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutinin. PLoS One 10:e139236

    Google Scholar 

  124. Samsa MM, Mondotte JA, Iglesias NG et al (2009) Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog 5(10):e1000632

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  125. Sepúlveda CS, García CC, Damonte EB (2010) Inhibition of arenavirus infection by thiuram and aromatic disulfides. Antiviral Res 87(3):329–337

    Article  PubMed  CAS  Google Scholar 

  126. Sepúlveda CS, García CC, Fascio ML et al (2012) Inhibition of Junín virus RNA synthesis by an antiviral acridone derivative. Antiviral Res 93(1):16–22

    Article  PubMed  CAS  Google Scholar 

  127. Sepúlveda CS, García CC, Levingston Macleod JM et al (2013) Targeting of arenavirus RNA synthesis by a carboxamide-derivatized aromatic disulfide with virucidal activity. PLoS One 8(11):e81251

    Article  PubMed  PubMed Central  Google Scholar 

  128. Shukla D, Spear PG (2001) Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry. J Clin Invest 108:503–510

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Silva IT, Costa GM, Stoco PH et al (2010) In vitro antiherpes effects of a C-glycosylflavonoid-enriched fraction of Cecropia glaziovii Sneth. Lett Appl Microbiol 51(2):143–148

    CAS  PubMed  Google Scholar 

  130. Soares AR, Abrantes JL, Lopes Souza TM et al (2007) In vitro antiviral effect of meroditerpenes isolated from the Brazilian seaweed Stypopodium zonale (Dictyotales). Planta Med 73:1221–1224

    Article  CAS  PubMed  Google Scholar 

  131. Soares JA, Leite FG, Andrade LG et al (2009) Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication. J Virol 83(13):6883–6899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Soto-Acosta R, Bautista-Carbajal P, Syed GH et al (2014) Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus. Antiviral Res 109:132–140

    Article  CAS  PubMed  Google Scholar 

  133. Souza TM, Abrantes JL, de A Epifanio R et al (2007a) The alkaloid 4-methylaaptamine isolated from the sponge Aaptos aaptos impairs herpes simplex virus type 1 penetration and immediate-early protein synthesis. Planta Med 73:200–205

    Article  CAS  PubMed  Google Scholar 

  134. Souza TM, De Souza MC, Ferreira VF et al (2007b) The chloroxoquinolinic derivative 6-chloro-1,4-dihydro-4-oxo-1-(beta-d-ribofuranosyl) quinoline-3-carboxylic acid inhibits HSV-1 adsorption by impairing its adsorption on HVEM. Arch Virol 152(7):1417–1424

    Article  CAS  PubMed  Google Scholar 

  135. Souza TM, De Souza MC, Ferreira VF et al (2008) Inhibition of HSV-1 replication and HSV DNA polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-d-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone. Antiviral Res 77(1):20–27

    Article  CAS  PubMed  Google Scholar 

  136. Souza TM, Rodrigues DQ, Ferreira VF et al (2009) Characterization of HIV-1 enzyme reverse transcriptase inhibition by the compound 6-chloro-1,4-dihydro-4-oxo-1-(beta-d-ribofuranosyl) quinoline-3-carboxylic acid through kinetic and in silico studies. Curr HIV Res 7(3):327–335

    Article  CAS  PubMed  Google Scholar 

  137. Spindola KC, Simas NK, Salles TS et al (2014) Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae). Parasit Vectors 7:537

    Article  PubMed  PubMed Central  Google Scholar 

  138. Talarico LB, Pujol CA, Zibetti RG et al (2005) The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell. Antiviral Res 66:103–110

    Article  CAS  PubMed  Google Scholar 

  139. Talarico LB, Damonte EB (2007) Interference in dengue virus adsorption and uncoating by carrageenans. Virology 363:473–485

    Article  CAS  PubMed  Google Scholar 

  140. Talarico LB, Damonte EB (2016) Characterization of in vitro dengue virus resistance to carrageenan. J Med Virol 88:1120–1129

    Article  CAS  PubMed  Google Scholar 

  141. Téllez MA, Téllez AN, Vélez F, Ulloa J (2015) In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae). BMC Complement Altern Med 15(1):428

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  142. Tischer PC, Talarico LB, Noseda MD et al (2006) Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus. Carbohydr Polym 63:459–465

    Article  CAS  Google Scholar 

  143. Toledo KA, Fermino ML, Andrade Cde C et al (2014) Galectin-1 exerts inhibitory effects during DENV-1 infection. PLoS One 9(11):e112474

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  144. Torres J, López R, Cetina A et al (2012b) Prediction of antiviral peptides derived from viral fusion proteins potentially active against herpes simplex and influenza A viruses. Bioinformation 8(18):870–874

    Article  Google Scholar 

  145. Torres NI, Castilla V, Bruttomesso AC et al (2012a) In vitro antiviral activity of dehydroepiandrosterone, 17 synthetic analogs and ERK modulators against herpes simplex virus type 1. Antiviral Res 95:37–48

    Article  CAS  PubMed  Google Scholar 

  146. Torres NI, Noll KS, Xu S et al (2013) Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1. Probiotics Antimicrob Proteins 5:26–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  147. Trinchero J, Ponce NM, Córdoba OL et al (2009) Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis. Phytother Res 23:707–712

    Article  CAS  PubMed  Google Scholar 

  148. Trujillo-Murillo K, Rincón-Sánchez AR, Martínez-Rodríguez H et al (2008) Acetylsalicylic acid inhibits hepatitis C virus RNA and protein expression through cyclooxygenase 2 signaling pathways. Hepatology 47(5):1462–1472

    Article  CAS  PubMed  Google Scholar 

  149. Vargas JE, Puga R, de Faria PJ et al (2015) A network flow approach to predict protein targets and flavonoid backbones to treat respiratory syncytial virus infection. Biomed Res Int 2015:301635

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  150. Visintini Jaime MF, Redko F, Muschietti LV et al (2013) In vitro antiviral activity of plant extracts from Asteraceae medicinal plants. Virol J 10:245

    Article  PubMed  PubMed Central  Google Scholar 

  151. Wachsman MB, Castilla V, Talarico LB et al (2004) Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one in vitro. Int J Antimicrob Agents 23(5):524–526

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Research in the authors’ laboratory was supported by Agencia Nacional de Promoción Científica y Tecnológica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), and Universidad de Buenos Aires (UBA), Argentina. C.S.S., C.C.G., and E.B.D. are members of Research Career from CONICET.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

    Viviana Castilla, Cybele C. García & Elsa B. Damonte

  2. IQUIBICEN-CONICET, Ciudad Universitaria, Pabellón 2, Piso 4, 1428, Buenos Aires, Argentina

    Claudia S. Sepúlveda, Cybele C. García & Elsa B. Damonte

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  1. Viviana Castilla
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  2. Claudia S. Sepúlveda
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  3. Cybele C. García
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  4. Elsa B. Damonte
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Correspondence to Elsa B. Damonte .

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Editors and Affiliations

  1. Instituto Politécnico Nacional, Center for Research and Advances Studies, Mexico City, Mexico

    Juan Ernesto Ludert

  2. Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela

    Flor H. Pujol

  3. Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay

    Juan Arbiza

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Castilla, V., Sepúlveda, C.S., García, C.C., Damonte, E.B. (2017). Progress for Antiviral Development in Latin America. In: Ludert, J., Pujol, F., Arbiza, J. (eds) Human Virology in Latin America. Springer, Cham. https://doi.org/10.1007/978-3-319-54567-7_22

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