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Adenoviruses: Biology and Epidemiology

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Human Virology in Latin America

Abstract

Adenoviruses (AdVs) are ubiquitous infectious agents distributed worldwide. First isolated from human adenoids by Rowe and colleagues in 1953 (Rowe et al. Proc Soc Exp Biol Med 84:570–573, 1953) and identified as causative agents of acute respiratory infections by Hilleman and Werner in 1954 (Hilleman and Werner. Proc Soc Exp Biol Med 85:183–188, 1954), these viruses were later shown to induce tumors in newborn hamsters by Trentin and colleagues in 1962. These discoveries established human AdVs as important human pathogens as well as a model system for the study of oncogenesis (Trentin et al. Science 137:835–841, 1962). Advances in the knowledge of the biology of AdVs after more than six decades of research have turned these viruses into tools for the development of gene therapy vectors and more recently as oncolytic agents for combined anticancer therapies. Human AdVs are estimated to be associated with a small proportion of acute respiratory morbidity in healthy adults and to be responsible for about 5% to 10% of respiratory illness in children.

The work of clinical virologists In Latin America has established AdV infections as major contributors to the etiology of pediatric respiratory disease requiring hospitalization. Diagnostic approaches of variable sensitivity have been utilized for the detection of AdV in clinical specimens, resulting in a wide variety of reported incidence figures. Overall, AdVs have been detected as the second or third most predominant respiratory virus among hospitalized children, frequently associated with severe clinical presentations requiring mechanical ventilation and resulting in pulmonary sequelae or a fatal outcome. Data are scarce for many counties and still missing for a few.

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Authors and Affiliations

  1. Lovelace Respiratory Research Institute, Albuquerque, NM, USA

    Adriana E. Kajon

  2. Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico

    Ramón A. Gonzalez

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  2. Ramón A. Gonzalez
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Correspondence to Adriana E. Kajon .

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Editors and Affiliations

  1. Instituto Politécnico Nacional, Center for Research and Advances Studies, Mexico City, Mexico

    Juan Ernesto Ludert

  2. Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela

    Flor H. Pujol

  3. Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay

    Juan Arbiza

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Kajon, A.E., Gonzalez, R.A. (2017). Adenoviruses: Biology and Epidemiology. In: Ludert, J., Pujol, F., Arbiza, J. (eds) Human Virology in Latin America. Springer, Cham. https://doi.org/10.1007/978-3-319-54567-7_14

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