Investigation and Management of TGA

  • A. J. Larner


This chapter considers the investigation and management of TGA. Investigations undertaken when patients are seen after the event, the most common clinical scenario, are generally normal and probably unnecessary if a definite (criteria-based) clinical diagnosis of pure TGA has been made. Investigations during the attack have clarified the exact nature of the neuropsychological deficit and revealed neuroimaging changes within memory-eloquent brain structures, possibly shedding light on disease pathogenesis. Since TGA is self-limiting, no specific treatment or management advice is required. Patients are sometimes erroneously told that they cannot drive.


TGA Neuropsychology Neuroimaging Neurophysiology 


  1. Abdel-Aziz K, Larner AJ. Six-item Cognitive Impairment Test (6CIT): pragmatic diagnostic accuracy study for dementia and MCI. Int Psychogeriatr. 2015;27:991–7.PubMedCrossRefGoogle Scholar
  2. Agosti C, Borroni B, Akkawi NM, De Maria G, Padovani A. Transient global amnesia and brain lesions: new hints into clinical criteria. Eur J Neurol. 2008;15:981–4.PubMedCrossRefGoogle Scholar
  3. Agosti C, Borroni B, Akkawi N, Padovani A. Cerebrovascular risk factors and triggers in transient global amnesia patients with and without jugular valve incompetence: results from a sample of 243 patients. Eur Neurol. 2010;63:291–4.PubMedCrossRefGoogle Scholar
  4. Ahn S, Kim W, Lee YS, et al. Transient global amnesia: seven years of experience with diffusion-weighted imaging in an emergency department. Eur Neurol. 2011;65:123–8.PubMedCrossRefGoogle Scholar
  5. Akkawi NM, Agosti C, Rozzini L, Anzola GP, Padovani A. Transient global amnesia and disturbance of venous flow patterns. Lancet. 2001;357:957.PubMedCrossRefGoogle Scholar
  6. Alberici E, Pichiecchio A, Caverzasi E, et al. Transient global amnesia: hippocampal magnetic resonance imaging abnormalities. Funct Neurol. 2008;23:149–52.PubMedGoogle Scholar
  7. Anderson SW, Rizzo M, Skaar N, et al. Amnesia and driving. J Clin Exp Neuropsychol. 2007;29:1–12.PubMedCrossRefGoogle Scholar
  8. Asada T, Matsuda H, Morooka T, Nakano S, Kimura M, Uno M. Quantitative single photon emission tomography analysis for the diagnosis of transient global amnesia: adaptation of statistical parametric mapping. Psychiatry Clin Neurosci. 2000;54:691–4.PubMedCrossRefGoogle Scholar
  9. Auyeung M, Tsoi TH, Cheung CM, et al. Association of diffusion weighted imaging abnormalities and recurrence in transient global amnesia. J Clin Neurosci. 2011;18:531–4.PubMedCrossRefGoogle Scholar
  10. Ay H, Furie KL, Yamada K, Koroshetz WJ. Diffusion-weighted MRI characterizes the ischemic lesion in transient global amnesia. Neurology. 1998;51:901–3.PubMedCrossRefGoogle Scholar
  11. Baddeley AD. Working memory. Oxford: Oxford University Press; 1986.Google Scholar
  12. Baracchini C, Tonello S, Farina F, et al. Jugular veins in transient global amnesia: innocent bystanders. Stroke. 2012;43:2289–92.PubMedCrossRefGoogle Scholar
  13. Baracchini C, Farina F, Ballotta E, Meneghetti G, Manara R. No signs of intracranial arterial vasoconstriction in transient global amnesia. J Neuroimaging. 2015;25:92–6.PubMedCrossRefGoogle Scholar
  14. Baron JC, Petit-Taboué MC, Le Doze F, Desgranges B, Ravenel N, Marchal G. Right frontal cortex hypometabolism in transient global amnesia. A PET Study. Brain. 1994;117:545–52.Google Scholar
  15. Bartsch T, Alfke K, Stingele R, et al. Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae. Brain. 2006;129:2874–84.PubMedCrossRefGoogle Scholar
  16. Bartsch T, Alfke K, Deuschl G, Jansen O. Evolution of hippocampal CA-1 diffusion lesions in transient global amnesia. Ann Neurol. 2007;62:475–80.PubMedCrossRefGoogle Scholar
  17. Bartsch T, Alfke K, Wolff S, Rohr A, Jansen O, Deuschl G. Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia. Neurology. 2008;70:1030–5.PubMedCrossRefGoogle Scholar
  18. Bartsch T, Schonfeld R, Muller FJ, et al. Focal lesions of human hippocampal CA1 neurons in transient global amnesia impair place memory. Science. 2010;328:1412–5.PubMedCrossRefGoogle Scholar
  19. Bender MB. Single episode of confusion with amnesia. Bull NY Acad Med. 1960;36:197–207.Google Scholar
  20. Berlit P. Successful prophylaxis of recurrent transient global amnesia with metoprolol. Neurology. 2000;55:1937–8.PubMedCrossRefGoogle Scholar
  21. Brooke P, Bullock R. Validation of a 6 item cognitive impairment test with a view to primary care usage. Int J Geriatr Psychiatry. 1999;14:936–40.PubMedCrossRefGoogle Scholar
  22. Bucuk M, Muzur A, Willheim K, Jurjevic A, Tomic Z, Tuskan ML. Make love to forget: two cases of transient global amnesia triggered by sexual intercourse. Coll Anthropol. 2004;28:899–905.Google Scholar
  23. Caffarra P, Moretti G, Mazzucchi A, Parma M. Neuropsychological testing during a transient global amnesia episode and its follow-up. Acta Neurol Scand. 1981;63:44–50.PubMedCrossRefGoogle Scholar
  24. Caplan LB [sic]. Transient global amnesia. In: Frederiks JAM, editor. Handbook of clinical neurology. Vol. 1 (45). Clinical neuropsychology. Amsterdam: Elsevier; 1985. p. 205–218.Google Scholar
  25. Caplan LR. Transient global amnesia and jugular vein incompetence. Stroke. 2010;41:e568.PubMedCrossRefGoogle Scholar
  26. Cartlidge NE. Transient global amnesia. BMJ. 1991;302:62–3.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Cejas C, Cisneros LF, Lagos R, Zuk C, Ameriso SF. Internal jugular vein valve incompetence is highly prevalent in transient global amnesia. Stroke. 2010;41:67–71.PubMedCrossRefGoogle Scholar
  28. Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46:1019–27.PubMedCrossRefGoogle Scholar
  29. Choi BS, Kim JH, Jung C, Kim SY. High-resolution diffusion-weighted imaging increases lesion detectability in patients with transient global amnesia. AJNR Am J Neuroradiol. 2012;33:1771–4.PubMedCrossRefGoogle Scholar
  30. Cianfoni A, Tartaglione T, Gaudino S, et al. Hippocampal magnetic resonance imaging abnormalities in transient global amnesia. Arch Neurol. 2005;62:1468–9.PubMedCrossRefGoogle Scholar
  31. Cole AJ, Gloor P, Kaplan R. Transient global amnesia: the electroencephalogram at onset. Ann Neurol. 1987;22:771–2.PubMedCrossRefGoogle Scholar
  32. Döhring J, Schmuck A, Bartsch T. Stress-related factors in the emergence of transient global amnesia with hippocampal lesions. Front Behav Neurosci. 2014;8:287.PubMedPubMedCentralGoogle Scholar
  33. Dugan TM, Nordgren RE, O’Leary P. Transient global amnesia associated with bradycardia and temporal lobe spikes. Cortex. 1981;17:633–7.PubMedCrossRefGoogle Scholar
  34. Dupuis MM, Pierre PH, Gonsette RE. Transient global amnesia and migraine in twin sisters. J Neurol Neurosurg Psychiatry. 1987;50:816–7.PubMedPubMedCentralCrossRefGoogle Scholar
  35. Enzinger C, Thimary F, Kapeller P, et al. Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease. Stroke. 2008;39:2219–25.PubMedCrossRefGoogle Scholar
  36. Eustache F, Desgranges B, Petit-Taboué MC, et al. Transient global amnesia: implicit/explicit memory dissociation and PET assessment of brain perfusion and oxygen metabolism in the acute stage. J Neurol Neurosurg Psychiatry. 1997;63:357–67.PubMedPubMedCentralCrossRefGoogle Scholar
  37. Eustache F, Desgranges B, Laville P, et al. Episodic memory in transient global amnesia: encoding, storage, or retrieval deficit? J Neurol Neurosurg Psychiatry. 1999;66:148–54.PubMedPubMedCentralCrossRefGoogle Scholar
  38. Evans J, Wilson B, Wraight EP, Hodges JR. Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. J Neurol Neurosurg Psychiatry. 1993;56:1227–30.PubMedPubMedCentralCrossRefGoogle Scholar
  39. Felix MM, Castro LH, Maia Jr AC, da Rocha AJ. Evidence of acute ischaemic tissue change in transient global amnesia in magnetic resonance imaging: case report and literature review. J Neuroimaging. 2005;15:203–5.PubMedCrossRefGoogle Scholar
  40. Fernandez A, Rincon F, Mazer SP, Elkind MS. Magnetic resonance imaging changes in a patient with migraine attack and transient global amnesia after cardiac catheterization. CNS Spectr. 2005;10:980–3.PubMedCrossRefGoogle Scholar
  41. Fisher CM. Transient global amnesia. Precipitating activities and other observations. Arch Neurol. 1982;39:605–8.PubMedCrossRefGoogle Scholar
  42. Fisher CM, Adams RD. Transient global amnesia. Trans Am Neurol Assoc. 1958;83:143–6.Google Scholar
  43. Fisher CM, Adams RD. Transient global amnesia. Acta Neurol Scand. 1964;40(Suppl 9):1–81.Google Scholar
  44. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res. 1975;12:189–98.CrossRefGoogle Scholar
  45. Förster A, Griebe M, Gass A, Kern R, Hennerici MG, Szabo K. Diffusion-weighted imaging for the differential diagnosis of disorders affecting the hippocampus. Cerebrovasc Dis. 2012;33:104–15.PubMedCrossRefGoogle Scholar
  46. Förster A, Al-Zghloul M, Kerl HU, Böhme J, Mürle B, Groden C. Value of dynamic susceptibility contrast perfusion MRI in the acute phase of transient global amnesia. PLoS One. 2015;10(3):e0122537.PubMedPubMedCentralCrossRefGoogle Scholar
  47. Fujii K, Sadoshima S, Ishitsuka T, et al. Regional cerebral blood flow and metabolism in patients with transient global amnesia: a positron emission tomography study. J Neurol Neurosurg Psychiatry. 1989;52:622–30.PubMedPubMedCentralCrossRefGoogle Scholar
  48. Gallassi R, Lorusso S, Stracciari A. Neuropsychological findings during a transient global amnesia attack and its follow-up. Ital J Neurol Sci. 1986;7:45–9.PubMedCrossRefGoogle Scholar
  49. Galvin JE, Roe CM, Powlishta KK, et al. The AD8. A brief informant interview to detect dementia. Neurology. 2005;65:559–64.PubMedCrossRefGoogle Scholar
  50. Galvin JE, Roe CM, Xiong C, Morris JE. Validity and reliability of the AD8 informant interview in dementia. Neurology. 2006;67:1942–8.PubMedCrossRefGoogle Scholar
  51. Garcia-Carrasco M, Galarza C, Gomez-Ponce M, et al. Antiphospholipid syndrome in Latin American patients: clinical and immunologic characteristics and comparison with European patients. Lupus. 2007;16:366–73.PubMedCrossRefGoogle Scholar
  52. Gass A, Gaa J, Hirsch J, Schwartz A, Hennerici MG. Lack of evidence of acute ischemic tissue change in transient global amnesia on single-shot echo-planar diffusion-weighted MRI. Stroke. 1999;30:2070–2.PubMedCrossRefGoogle Scholar
  53. Goldenberg G. Transient global amnesia. In: Baddeley AD, Wilson BA, Watts FN, editors. Handbook of memory disorders. Chichester: Wiley; 1995. p. 113–4.Google Scholar
  54. Goldenberg G, Podreka I, Pfaffelmeyer N, Wessely P, Deecke L. Thalamic ischemia in transient global amnesia: a SPECT study. Neurology. 1991;41:1748–52.PubMedCrossRefGoogle Scholar
  55. Gonzalez-Martinez V, Comte F, de Verbizier D, Carlander B. Transient global amnesia: concordant hippocampal abnormalities on positron emission tomography and magnetic resonance imaging. Arch Neurol. 2010;67:510–1.PubMedCrossRefGoogle Scholar
  56. Gordon B, Marin O. Transient global amnesia: an extensive case report. J Neurol Neurosurg Psychiatry. 1979;42:572–5.PubMedPubMedCentralCrossRefGoogle Scholar
  57. Greene HH, Bennett DR. Transient global amnesia with a previously unreported EEG abnormality. Electroencephalogr Clin Neurophysiol. 1974;36:409–13.PubMedCrossRefGoogle Scholar
  58. Greer DM, Schaefer PW, Schwamm LH. Unilateral temporal lobe stroke causing ischemic transient global amnesia: role for diffusion-weighted imaging in the initial evaluation. J Neuroimaging. 2001;11:317–9.PubMedCrossRefGoogle Scholar
  59. Guillery B, Desgranges B, Katis S, de la Sayette V, Viader F, Eustache F. Semantic acquisition without memories: evidence from transient global amnesia. Neuroreport. 2001;12:3865–9.PubMedCrossRefGoogle Scholar
  60. Guillery B, Desgranges B, de la Sayette V, Landeau B, Eustache F, Baron JC. Transient global amnesia: concomitant episodic memory and positron emission tomography assessment in two additional patients. Neurosci Lett. 2002;325:62–6.PubMedCrossRefGoogle Scholar
  61. Hodges JR. Transient amnesia. Clinical and neuropsychological aspects. London: WB Saunders; 1991.Google Scholar
  62. Hodges JR. Semantic memory and frontal executive function during transient global amnesia. J Neurol Neurosurg Psychiatry. 1994;57:605–8.PubMedPubMedCentralCrossRefGoogle Scholar
  63. Hodges JR. Transient semantic amnesia: a new syndrome? J Neurol Neurosurg Psychiatry. 1997;63:548–9.PubMedPubMedCentralCrossRefGoogle Scholar
  64. Hodges JR, Ward CD. Observations during transient global amnesia. A behavioural and neuropsychological study of five cases. Brain. 1989;112:595–620.PubMedCrossRefGoogle Scholar
  65. Hodges JR, Warlow CP. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry. 1990;53:834–43.PubMedPubMedCentralCrossRefGoogle Scholar
  66. Hsieh S, McGrory S, Leslie F, et al. The mini-Addenbrooke’s cognitive examination: a new assessment tool for dementia. Dement Geriatr Cogn Disord. 2015;39:1–11.PubMedCrossRefGoogle Scholar
  67. Huang CF, Pai MC. Transient amnesia in a patient with left temporal tumor. Symptomatic transient global amnesia or an epileptic amnesia? Neurologist. 2008;14:196–200.PubMedCrossRefGoogle Scholar
  68. Huber R, Aschoff AJ, Ludolph AC, Riepe MW. Transient global amnesia. Evidence against vascular ischemic etiology from diffusion weighted imaging. J Neurol. 2002;249:1520–4.PubMedCrossRefGoogle Scholar
  69. Inamura T, Nakazaki K, Yasuda O, et al. A lesion diagnosed by MRI in a case of transient global amnesia [in Japanese]. No To Shinkei. 2002;54:419–22.PubMedGoogle Scholar
  70. Jacome DE. EEG features in transient global amnesia. Clin Electroencephalogr. 1989;20:183–92.PubMedCrossRefGoogle Scholar
  71. Jaffe R, Bender MB. E.E.G. studies in the syndrome of isolated episodes of confusion with amnesia “transient global amnesia”. J Neurol Neurosurg Psychiatry. 1966;29:472–4.PubMedPubMedCentralCrossRefGoogle Scholar
  72. Jäger T, Bazner H, Kliegel M, Szabo K, Hennerici MG. The transience and nature of cognitive impairments in transient global amnesia: a meta-analysis. J Clin Exp Neuropsychol. 2009;31:8–19.PubMedCrossRefGoogle Scholar
  73. Jalanko M, Forsström F, Lassus J. Cardiac troponin T elevation associated with transient global amnesia: another differential diagnosis of “troponosis”. Eur Heart J Acute Cardiovasc Care. 2015;4:561–4.PubMedCrossRefGoogle Scholar
  74. Jeong HS, Moon JS, Baek IC, Lee AY, Kim JM. Transient global amnesia with post-hyperventilation temporal sharp waves – a case report. Seizure. 2010;19:609–11.PubMedCrossRefGoogle Scholar
  75. Jia J, Wang L, Yin L, Tang H. Contrast study on cognitive function with MRI and positron emission tomography imaging in transient global amnesia. Chin Med J. 2002;115:1321–3.PubMedGoogle Scholar
  76. Jovin TG, Vitti RA, McCluskey LF. Evolution of temporal lobe hypoperfusion in transient global amnesia: a serial single photon emission computed tomography study. J Neuroimaging. 2000;10:238–41.PubMedCrossRefGoogle Scholar
  77. Kapur N, Abbott P, Footitt D, Millar J. Long-term perceptual priming in transient global amnesia. Brain Cogn. 1996;31:63–74.PubMedCrossRefGoogle Scholar
  78. Kessler J, Markowitsch HJ, Rudolf J, Heiss WD. Continuing cognitive impairment after isolated transient global amnesia. Int J Neurosci. 2001;106:159–68.PubMedCrossRefGoogle Scholar
  79. Kim BS, Cho SS, Choi JY, Kim YH. Transient global amnesia: a study with Tc-99m ECD SPECT shortly after symptom onset and recovery. Diagn Interv Radiol. 2016;22:476–80.PubMedPubMedCentralCrossRefGoogle Scholar
  80. Kim J, Kwon Y, Yang Y, et al. Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia: an 8-year large-scale clinical study. J Neuroimaging. 2014;24:331–7.PubMedCrossRefGoogle Scholar
  81. Kritchevsky M. Transient global amnesia. In: Squire LR, Butters N, editors. Neuropsychology of memory. 2nd ed. New York: Guilford Press; 1992. p. 147–55.Google Scholar
  82. Kritchevsky M, Squire LR. Transient global amnesia: evidence for extensive temporally graded retrograde amnesia. Neurology. 1989;39:213–8.PubMedCrossRefGoogle Scholar
  83. Kritchevsky M, Squire LR, Zouzounis JA. Transient global amnesia: characterization of anterograde and retrograde amnesia. Neurology. 1988;38:213–9.PubMedCrossRefGoogle Scholar
  84. LaBar KS, Gitelman DR, Parrish TB, Mesulam M-M. Functional changes in temporal lobe activity during transient global amnesia. Neurology. 2002;58:638–41.PubMedCrossRefGoogle Scholar
  85. Laloux P, Brichant C, Cauwe F, Decoster P. Technetium-99m HM-PAO single photon emission computed tomography imaging in transient global amnesia. Arch Neurol. 1992;49:543–6.PubMedCrossRefGoogle Scholar
  86. Lampl Y, Sadeh M, Lorberboym M. Transient global amnesia – not always a benign process. Acta Neurol Scand. 2004;110:75–9.PubMedCrossRefGoogle Scholar
  87. Larner AJ. Transient global amnesia in the district general hospital. Int J Clin Pract. 2007;61:255–8.PubMedCrossRefGoogle Scholar
  88. Larner AJ. Dementia in clinical practice: a neurological perspective. Pragmatic studies in the cognitive function clinic. 2nd ed. London: Springer; 2014.CrossRefGoogle Scholar
  89. Larner AJ. Diagnostic test accuracy studies in dementia. A pragmatic approach. London: Springer; 2015a.Google Scholar
  90. Larner AJ. Mini-Addenbrooke’s Cognitive Examination: a pragmatic diagnostic accuracy study. Int J Geriatr Psychiatry. 2015b;30:547–8.PubMedCrossRefGoogle Scholar
  91. Larner AJ. Implications of changing the Six-item Cognitive Impairment Test cutoff. Int J Geriatr Psychiatry. 2015c;30:778–9.Google Scholar
  92. Larner AJ. AD8 informant questionnaire for cognitive impairment: pragmatic diagnostic test accuracy study. J Geriatr Psychiatry Neurol. 2015d;28:198–202.PubMedCrossRefGoogle Scholar
  93. Larner AJ. Mini-Addenbrooke’s Cognitive Examination diagnostic accuracy for dementia: reproducibility study. Int J Geriatr Psychiatry. 2015e;30:1103–4.Google Scholar
  94. Larner AJ. M-ACE vs. MoCA. A weighted comparison. Int J Geriatr Psychiatry. 2016;31:1089–90.PubMedCrossRefGoogle Scholar
  95. Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017.Google Scholar
  96. Lee HY, Kim JH, Weon YC, et al. Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus. Neuroradiology. 2007;49:481–7.PubMedCrossRefGoogle Scholar
  97. Lee SY, Kim WJ, Suh SH, Oh SH, Lee KY. Higher lesion detection by 3.0T MRI in patient with transient global amnesia. Yonsei Med J. 2009;50:211–4.PubMedPubMedCentralCrossRefGoogle Scholar
  98. Lewis SL. Aetiology of transient global amnesia. Lancet. 1998;352:397–9.PubMedCrossRefGoogle Scholar
  99. Lezak MD, Howieson DB, Bigler ED, Tranel D. Neuropsychological assessment. 5th ed. New York: Oxford University Press; 2012.Google Scholar
  100. Li J, Hu WL. Bilateral hippocampal abnormalities in magnetic resonance imaging in transient global amnesia. Am J Emerg Med. 2013;31:755e1–3.Google Scholar
  101. Lochner P, Nedelmann M, Kaps M, Stolz E. Jugular valve incompetence in transient global amnesia. A problem revisited. J Neuroimaging. 2014;24:479–83.PubMedCrossRefGoogle Scholar
  102. Lorente de No R. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. J Psychol Neurol. 1934;46:113–77.Google Scholar
  103. Lou H. Repeated episodes of transient global amnesia. Acta Neurol Scand. 1968;44:612–8.PubMedCrossRefGoogle Scholar
  104. Maalikjy Akkawi N, Agosti C, Anzola GP, et al. Transient global amnesia: a clinical and sonographic study. Eur Neurol. 2003;49:67–71.PubMedCrossRefGoogle Scholar
  105. Marin-Garcia E, Ruiz-Vargas JM, Kapur N. Mere exposure effect can be elicited in transient global amnesia. J Clin Exp Neuropsychol. 2013;35:1007–14.PubMedCrossRefGoogle Scholar
  106. Matias-Guiu J, Masague I, Codina A. Transient global amnesia and high haematocrit levels. J Neurol. 1985a;232:383–4.PubMedCrossRefGoogle Scholar
  107. Matias-Guiu J, Garcia C, Galdos L, Codina A. Prolactin concentrations in serum unchanged in transient global amnesia. Clin Chem. 1985b;31:1764.PubMedGoogle Scholar
  108. Matsuda H, Higashi S, Tsuji S, et al. High resolution Tc-99m HMPAO SPECT in a patient with transient global amnesia. Clin Nucl Med. 1993;18:46–9.PubMedCrossRefGoogle Scholar
  109. Matsui M, Imamura T, Sakamoto S, Ishii K, Kazui H, Mori E. Transient global amnesia: increased signal intensity in the right hippocampus on diffusion-weighted magnetic resonance imaging. Neuroradiology. 2002;44:235–8.PubMedCrossRefGoogle Scholar
  110. Miller JW, Yanagihara T, Petersen RC, Klass DW. Transient global amnesia and epilepsy: electroencephalographic distinction. Arch Neurol. 1987;44:629–33.PubMedCrossRefGoogle Scholar
  111. Mizuno-Matsumoto Y, Ishijima M, Shinosaki K, et al. Transient global amnesia (TGA) in an [sic] MEG study. Brain Topogr. 2001;13:269–74.PubMedCrossRefGoogle Scholar
  112. Modabbernia A, Taslimi S, Ashrafi M, Modabbernia MJ, Hu HH. Internal jugular vein reflux in patients with transient global amnesia: a meta-analysis of case-control studies. Acta Neurol Belg. 2012;112:237–44.PubMedCrossRefGoogle Scholar
  113. Moreno-Lugris XC, Martinez-Alvarez J, Branas F, Martinez-Vazquez F, Cortes-Laino JA. Transient global amnesia. Case-control study of 24 cases [in Spanish]. Rev Neurol. 1996;24:554–7.PubMedGoogle Scholar
  114. Morris Z, Whiteley WN, Longstreth WT, et al. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2009;339:547–50.Google Scholar
  115. Nakada T, Kwee IL, Fujii Y, Knight RT. High-field, T2 reversed MRI of the hippocampus in transient global amnesia. Neurology. 2005;64:1170–4.PubMedCrossRefGoogle Scholar
  116. Nardone R, Buffone EC, Matullo MF, Tezzon F. Motor cortex excitability in transient global amnesia. J Neurol. 2004;251:42–6.PubMedCrossRefGoogle Scholar
  117. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.Google Scholar
  118. Nedelmann M, Eicke BM, Dieterich M. Increased incidence of jugular valve insufficiency in patients with transient global amnesia. J Neurol. 2005;252:1482–6.PubMedCrossRefGoogle Scholar
  119. Oghino Y, Yokoi F, Nishio T, Sunohara N, Satayoshi E. Positron emission tomography in two cases of transient global amnesia [in Japanese]. Rinsho Shinkeigaku. 1989;29:599–605.PubMedGoogle Scholar
  120. O’Keefe J, Nadel L. The hippocampus as a cognitive map. Oxford: Oxford University Press; 1978.Google Scholar
  121. Pedley TA. Differential diagnosis of episodic symptoms. Epilepsia. 1983;24(Suppl 1):S31–44.PubMedCrossRefGoogle Scholar
  122. Peer M, Nitzan M, Goldberg I, et al. Reversible functional connectivity disturbances during transient global amnesia. Ann Neurol. 2014;75:634–43.PubMedCrossRefGoogle Scholar
  123. Poser CM, Ziegler DK. Temporary amnesia as a manifestation of cerebrovascular insufficiency. Trans Am Neurol Assoc. 1960;85:221–3.PubMedGoogle Scholar
  124. Quinette P, Guillery B, Desgranges B, de la Sayette V, Viader F, Eustache F. Working memory and executive functions in transient global amnesia. Brain. 2003;126:1917–34.PubMedCrossRefGoogle Scholar
  125. Regard M, Landis T. Transient global amnesia: neuropsychological dysfunction during attack and recovery in two “pure” cases. J Neurol Neurosurg Psychiatry. 1984;47:668–72.PubMedPubMedCentralCrossRefGoogle Scholar
  126. Ryoo I, Kim JH, Kim S, Choi BS, Jung C, Hwang SI. Lesion detectability on diffusion-weighted imaging in transient global amnesia: the influence of imaging timing and magnetic field strength. Neuroradiology. 2012;54:329–34.PubMedCrossRefGoogle Scholar
  127. Sakashita Y, Sugimoto T, Taki S, Matsuda H. Abnormal cerebral blood flow following transient global amnesia. J Neurol Neurosurg Psychiatry. 1993;56:1327.PubMedPubMedCentralCrossRefGoogle Scholar
  128. Sander D, Winbeck K, Etgen T, Knapp R, Klingelhofer J, Conrad B. Disturbance of venous flow patterns in patients with transient global amnesia. Lancet. 2000;356:1982–4.PubMedCrossRefGoogle Scholar
  129. Sander K, Sander D. New insights into transient global amnesia: recent imaging and clinical findings. Lancet Neurol. 2005;4:437–44.PubMedCrossRefGoogle Scholar
  130. Scheel M, Malkowsky C, Klingebiel R, Schreiber SJ, Bohner G. Magnetic resonance imaging in transient global amnesia: lessons learned from 198 cases. Clin Neuroradiol. 2012;22:335–40.PubMedCrossRefGoogle Scholar
  131. Schmidtke K, Reinhardt M, Krause T. Cerebral hypoperfusion during transient global amnesia: findings with HMPAO SPECT. J Nucl Med. 1998;39:155–9.Google Scholar
  132. Schreiber SJ, Doepp F, Klingebiel R, Valdueza JM. Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. J Neurol Neurosurg Psychiatry. 2005;76:509–13.PubMedPubMedCentralCrossRefGoogle Scholar
  133. Sealove BA, Aledort LM, Stacy CB, Halperin JL. Recurrent orthostatic global amnesia in a patient with postoperative hyperfibrinogenemia. J Stroke Cerebrovasc Dis. 2008;17:241–3.PubMedCrossRefGoogle Scholar
  134. Sedlaczek O, Hirsch JG, Grips E, et al. Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology. 2004;62:2165–70.PubMedCrossRefGoogle Scholar
  135. Shuping JR, Rollinson RD, Toole JF. Transient global amnesia. Ann Neurol. 1980;7:281–5.PubMedCrossRefGoogle Scholar
  136. Stillhard G, Landis T, Schiess R, Regard M, Sialer G. Bitemporal hypoperfusion in transient global amnesia: 99m-Tc-HM-PAO SPECT and neuropsychological findings during and after an attack. J Neurol Neurosurg Psychiatry. 1990;53:339–42.PubMedPubMedCentralCrossRefGoogle Scholar
  137. Stippich C, Kassubek J, Kober H, Soros P, Vieth JB. Time course of focal slow wave activity in transient ischemic attacks and transient global amnesia as measured by magnetoencephalography. Neuroreport. 2000;11:3309–13.PubMedCrossRefGoogle Scholar
  138. Strupp M, Brüning R, Wu RH, Deimling M, Reiser M, Brandt T. Diffusion-weighted MRI in transient global amnesia: elevated signal intensity in the left mesial temporal lobe in 7 out of 10 patients. Ann Neurol. 1998;43:164–70.PubMedCrossRefGoogle Scholar
  139. Tanabe H, Hashikawa K, Nakagawa Y, et al. Memory loss due to transient hypoperfusion in the medial temporal lobes including hippocampus. Acta Neurol Scand. 1991;84:22–7. [Erratum Acta Neurol Scand. 1991; 84:463]PubMedCrossRefGoogle Scholar
  140. Tate RL. A compendium of tests, scales, and questionnaires. The practitioner’s guide to measuring outcomes after acquired brain impairment. Hove: Psychology Press; 2010.Google Scholar
  141. Tharp BR. The electroencephalogram in transient global amnesia. Electroencephalogr Clin Neurophysiol. 1969;26:96–9.PubMedCrossRefGoogle Scholar
  142. Tharp BR. Transient global amnesia: manifestation of medial temporal lobe epilepsy. Clin Electroencephalogr. 1979;10:54–6.PubMedCrossRefGoogle Scholar
  143. Toledo M, Pujadas F, Purroy F, Alvarez-Sabin J. Polycythaemia as a ready factor of transitory global amnesia [in Spanish]. Neurologia. 2005;20:317–20.PubMedGoogle Scholar
  144. Ueno H, Naka H, Ohshita T, Wakabayashi S, Matsumoto M. Serial changes in delayed focal hippocampal lesions in patients with transient global amnesia. Hiroshima J Med Sci. 2010;59:77–81.PubMedGoogle Scholar
  145. Ung KYC, Larner AJ. Transient amnesia: epileptic or global? A differential diagnosis with significant implications for management. Q J Med. 2014;107:915–7.CrossRefGoogle Scholar
  146. Uttner I, Weber S, Freund W, Schmitz B, Ramspott M, Huber R. Transient global amnesia – full recovery without persistent cognitive impairment. Eur Neurol. 2007;58:146–51.PubMedCrossRefGoogle Scholar
  147. Uttner I, Weber S, Freund W, et al. Hippocampal cavities are not associated with cognitive impairment in transient global amnesia. Eur J Neurol. 2011;18:882–7.PubMedCrossRefGoogle Scholar
  148. Vyhnalek M, Bojar M, Jerabek J, Hort J. Long lasting recurrent familiar [sic] transient global amnesia after betablocker withdrawal: case report. Neuro Endocrinol Lett. 2008;29:44–6.PubMedGoogle Scholar
  149. Warren JD, Chatterton B, Thompson PD. A SPECT study of the anatomy of transient global amnesia. J Clin Neurosci. 2000;7:57–9.PubMedCrossRefGoogle Scholar
  150. Weon YC, Kim JH, Lee JS, Kim SY. Optimal diffusion-weighted imaging protocol for lesion detection in transient global amnesia. AJNR Am J Neuroradiol. 2008;29:1324–8.PubMedCrossRefGoogle Scholar
  151. Westmacott R, Silver FL, McAndrews MP. Understanding medial temporal activation in memory tasks: evidence from fMRI of encoding and recognition in a case of transient global amnesia. Hippocampus. 2008;18:317–25.PubMedCrossRefGoogle Scholar
  152. Wilkinson T, Geranmayeh F, Dassan P, Janssen JC. Neuroimaging in transient global amnesia. Pract Neurol. 2013;13:56–7.PubMedCrossRefGoogle Scholar
  153. Winbeck K, Etgen T, von Einsiedel HG, Röttinger M, Sander D. DWI in transient global amnesia and TIA: proposal for an ischaemic origin of TGA. J Neurol Neurosurg Psychiatry. 2005;76:438–41.PubMedPubMedCentralCrossRefGoogle Scholar
  154. Woolfenden AR, O’Brien MW, Schwartzberg RE, Norbash AM, Tong DC. Diffusion-weighted MRI in transient global amnesia precipitated by cerebral angiography. Stroke. 1997;28:2311–4.PubMedCrossRefGoogle Scholar
  155. Yamane Y, Ishii K, Shimizu K, et al. Global cerebral hypoperfusion in a patient with transient global amnesia. J Comput Assist Tomogr. 2008;32:415–7.PubMedCrossRefGoogle Scholar
  156. Yang Y, Kim S, Kim JH. Ischemic evidence of transient global amnesia: location of the lesion in the hippocampus. J Clin Neurol. 2008;4:59–66.PubMedPubMedCentralCrossRefGoogle Scholar
  157. Zeman AZ. Episodic memory in transient global amnesia. J Neurol Neurosurg Psychiatry. 1999;66:135.PubMedPubMedCentralCrossRefGoogle Scholar
  158. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. 1986;6:2950–67.PubMedGoogle Scholar
  159. Zorzon M, Longo R, Mase G, Biasutti E, Vitrani B, Cazzato G. Proton magnetic resonance spectroscopy during transient global amnesia. J Neurol Sci. 1998;156:78–82.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • A. J. Larner
    • 1
  1. 1.Cognitive Function ClinicWalton Centre for Neurology and NeurosurgeryLiverpoolUK

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